{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T18:05:49Z","timestamp":1791655549892,"version":"4.3.4"},"reference-count":90,"publisher":"American Society for Microbiology","issue":"8","license":[{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Eukaryot Cell"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Antimicrobial peptides (AMPs) are key elements of innate immunity, which can directly kill multiple bacterial, viral, and fungal pathogens. The medically important fungus\n                    <jats:named-content content-type=\"genus-species\">Candida albicans<\/jats:named-content>\n                    colonizes different host niches as part of the normal human microbiota. Proliferation of\n                    <jats:named-content content-type=\"genus-species\">C. albicans<\/jats:named-content>\n                    is regulated through a complex balance of host immune defense mechanisms and fungal responses. Expression of AMPs against pathogenic fungi is differentially regulated and initiated by interactions of a variety of fungal pathogen-associated molecular patterns (PAMPs) with pattern recognition receptors (PRRs) on human cells. Inflammatory signaling and other environmental stimuli are also essential to control fungal proliferation and to prevent parasitism. To persist in the host,\n                    <jats:named-content content-type=\"genus-species\">C. albicans<\/jats:named-content>\n                    has developed a three-phase AMP evasion strategy, including secretion of peptide effectors, AMP efflux pumps, and regulation of signaling pathways. These mechanisms prevent\n                    <jats:named-content content-type=\"genus-species\">C. albicans<\/jats:named-content>\n                    from the antifungal activity of the major AMP classes, including cathelicidins, histatins, and defensins leading to a basal resistance. This minireview summarizes human AMP attack and\n                    <jats:named-content content-type=\"genus-species\">C. albicans<\/jats:named-content>\n                    resistance mechanisms and current developments in the use of AMPs as antifungal agents.\n                  <\/jats:p>","DOI":"10.1128\/ec.00093-14","type":"journal-article","created":{"date-parts":[[2014,6,21]],"date-time":"2014-06-21T03:51:26Z","timestamp":1403322686000},"page":"950-957","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":126,"title":["Interplay between Candida albicans and the Antimicrobial Peptide Armory"],"prefix":"10.1128","volume":"13","author":[{"given":"Marc","family":"Swidergall","sequence":"first","affiliation":[{"name":"Department Biologie, Molekulare Mykologie, Heinrich-Heine-Universit\u00e4t D\u00fcsseldorf, D\u00fcsseldorf, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim F.","family":"Ernst","sequence":"additional","affiliation":[{"name":"Department Biologie, Molekulare Mykologie, Heinrich-Heine-Universit\u00e4t D\u00fcsseldorf, D\u00fcsseldorf, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.06146-11"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2004.06.003"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2012.11.009"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0952-7915(99)80005-3"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro1441"},{"key":"e_1_3_2_7_2","first-page":"597","article-title":"Antimicrobial peptides: properties and applicability","volume":"382","author":"van't Hof W","year":"2001","unstructured":"van't HofWVeermanECHelmerhorstEJAmerongenAV. 2001. Antimicrobial peptides: properties and applicability. Biol. Chem. 382:597\u2013619.","journal-title":"Biol. Chem."},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11302-006-9040-0"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.imbio.2010.07.003"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20042099"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20111454"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0017755"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.5.3070"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1515\/BC.2006.187"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1021\/pr100861k"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2008.06480.x"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.311175"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002592"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.141366998"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.68.12.6848-6856.2000"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1128\/EC.00095-14"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.44.12.3310-3316.2000"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00470-08"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20030779"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M207587200"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2009.35"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.44.12.3257-3263.2000"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1139\/o11-085"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2012.254"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12004"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2672.2012.05338.x"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni1206"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2008.00832.x"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2010.08.002"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201041197"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2004.07.007"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.173.5.3482"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2010.01.007"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700346"},{"key":"e_1_3_2_40_2","first-page":"3664","article-title":"Human epithelial cells establish direct antifungal defense through TLR4-mediated signaling","volume":"117","author":"Weindl G","year":"2007","unstructured":"WeindlGNaglikJRKaeslerSBiedermannTHubeBKortingHCSchallerM. 2007. Human epithelial cells establish direct antifungal defense through TLR4-mediated signaling. J. Clin. Invest. 117:3664\u20133672.","journal-title":"J. Clin. Invest."},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0923-1811(02)00105-6"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00251.2010"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201142055"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00394-012-0415-4"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2172-10-36"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V90.7.2796"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63304-4"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro1710"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri3024"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1982.139"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2008.27"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.imbio.2010.08.008"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M301995200"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0005039"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00862-13"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002501"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1128\/EC.00133-10"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1128\/EC.00285-12"},{"key":"e_1_3_2_59_2","first-page":"579","article-title":"Antimicrobial peptide MUC7 12-mer activates the calcium\/calcineurin pathway in Candida albicans","volume":"10","author":"Lis M","year":"2010","unstructured":"LisMLiuTTBarkerKSRogersPDBobekLA. 2010. Antimicrobial peptide MUC7 12-mer activates the calcium\/calcineurin pathway in Candida albicans. FEMS Yeast Res. 10:579\u2013586.","journal-title":"FEMS Yeast Res."},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0046020"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02295-12"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1128\/EC.00039-07"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00365-13"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.023309-0"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1128\/EC.00402-07"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1002058"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/21.4.546"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.2003.03495.x"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00438-009-0423-0"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dki402"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000040"},{"key":"e_1_3_2_72_2","doi-asserted-by":"publisher","DOI":"10.1038\/415389a"},{"key":"e_1_3_2_73_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(09)70200-2"},{"key":"e_1_3_2_74_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2672.2009.04312.x"},{"key":"e_1_3_2_75_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00657-09"},{"key":"e_1_3_2_76_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003661"},{"key":"e_1_3_2_77_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00573-10"},{"key":"e_1_3_2_78_2","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.2010.493875"},{"key":"e_1_3_2_79_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00349-06"},{"key":"e_1_3_2_80_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(02)00181-0"},{"key":"e_1_3_2_81_2","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-7-44"},{"key":"e_1_3_2_82_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodhyd.2010.09.012"},{"key":"e_1_3_2_83_2","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.2008\/001263-0"},{"key":"e_1_3_2_84_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01851-13"},{"key":"e_1_3_2_85_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-60761-594-1_19"},{"key":"e_1_3_2_86_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2007.07.016"},{"key":"e_1_3_2_87_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2012.08017.x"},{"key":"e_1_3_2_88_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.467159"},{"key":"e_1_3_2_89_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2010.07210.x"},{"key":"e_1_3_2_90_2","doi-asserted-by":"publisher","DOI":"10.1177\/08959374000140010201"},{"key":"e_1_3_2_91_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01597-07"}],"container-title":["Eukaryotic Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/EC.00093-14","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/EC.00093-14","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,23]],"date-time":"2022-02-23T09:57:40Z","timestamp":1645610260000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/EC.00093-14"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8]]},"references-count":90,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["10.1128\/EC.00093-14"],"URL":"https:\/\/doi.org\/10.1128\/ec.00093-14","relation":{},"ISSN":["1535-9778","1535-9786"],"issn-type":[{"value":"1535-9778","type":"print"},{"value":"1535-9786","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8]]},"assertion":[{"value":"2014-07-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}