{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T11:22:10Z","timestamp":1790076130564,"version":"4.0.1"},"reference-count":69,"publisher":"American Society for Microbiology","issue":"8","license":[{"start":{"date-parts":[[2010,8,1]],"date-time":"2010-08-01T00:00:00Z","timestamp":1280620800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Eukaryot Cell"],"published-print":{"date-parts":[[2010,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            <jats:named-content content-type=\"genus-species\">Cryptococcus neoformans<\/jats:named-content>\n            is an environmental fungus and an opportunistic human pathogen. Previous studies have demonstrated major alterations in its transcriptional profile as this microorganism enters the hostile environment of the human host. To assess the role of chromatin remodeling in host-induced transcriptional responses, we identified the\n            <jats:named-content content-type=\"genus-species\">C. neoformans<\/jats:named-content>\n            Gcn5 histone acetyltransferase and demonstrated its function by complementation studies of\n            <jats:named-content content-type=\"genus-species\">Saccharomyces cerevisiae<\/jats:named-content>\n            . The\n            <jats:named-content content-type=\"genus-species\">C. neoformans<\/jats:named-content>\n            <jats:italic>gcn5<\/jats:italic>\n            \u0394 mutant strain has defects in high-temperature growth and capsule attachment to the cell surface, in addition to increased sensitivity to FK506 and oxidative stress. Treatment of wild-type cells with the histone acetyltransferase inhibitor garcinol mimics cellular effects of the\n            <jats:italic>gcn5<\/jats:italic>\n            <jats:italic>\u0394<\/jats:italic>\n            mutation. Gcn5 regulates the expression of many genes that are important in responding to the specific environmental conditions encountered by\n            <jats:named-content content-type=\"genus-species\">C. neoformans<\/jats:named-content>\n            inside the host. Accordingly, the\n            <jats:italic>gcn5<\/jats:italic>\n            <jats:italic>\u0394<\/jats:italic>\n            mutant is avirulent in animal models of cryptococcosis. Our study demonstrates the importance of chromatin remodeling by the conserved histone acetyltransferase Gcn5 in regulating the expression of specific genes that allow\n            <jats:named-content content-type=\"genus-species\">C. neoformans<\/jats:named-content>\n            to respond appropriately to the human host.\n          <\/jats:p>","DOI":"10.1128\/ec.00098-10","type":"journal-article","created":{"date-parts":[[2010,6,26]],"date-time":"2010-06-26T02:22:59Z","timestamp":1277518979000},"page":"1193-1202","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":88,"title":["Cryptococcus neoformans Histone Acetyltransferase Gcn5 Regulates Fungal Adaptation to the Host"],"prefix":"10.1128","volume":"9","author":[{"given":"Teresa R.","family":"O'Meara","sequence":"first","affiliation":[{"name":"Departments of Medicine and Molecular Genetics\/Microbiology, Duke University School of Medicine, Durham, North Carolina 27710"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christie","family":"Hay","sequence":"additional","affiliation":[{"name":"Departments of Medicine and Molecular Genetics\/Microbiology, Duke University School of Medicine, Durham, North Carolina 27710"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael S.","family":"Price","sequence":"additional","affiliation":[{"name":"Departments of Medicine and Molecular Genetics\/Microbiology, Duke University School of Medicine, Durham, North Carolina 27710"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve","family":"Giles","sequence":"additional","affiliation":[{"name":"Departments of Medicine and Molecular Genetics\/Microbiology, Duke University School of Medicine, Durham, North Carolina 27710"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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