{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T19:25:31Z","timestamp":1790364331771,"version":"4.1.0"},"reference-count":49,"publisher":"American Society for Microbiology","issue":"8","license":[{"start":{"date-parts":[[2009,8,1]],"date-time":"2009-08-01T00:00:00Z","timestamp":1249084800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Eukaryot Cell"],"published-print":{"date-parts":[[2009,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The ability to sense and adapt to a hostile host environment is a crucial element for virulence of pathogenic fungi, including\n                    <jats:italic>Cryptococcus neoformans<\/jats:italic>\n                    . These cellular responses are evoked by diverse signaling cascades, including the stress-activated HOG pathway. Despite previous analysis of central components of the HOG pathway, its downstream signaling network is poorly characterized in\n                    <jats:italic>C. neoformans<\/jats:italic>\n                    . Here we performed comparative transcriptome analysis with HOG signaling mutants to explore stress-regulated genes and their correlation with the HOG pathway in\n                    <jats:italic>C. neoformans<\/jats:italic>\n                    . In this study, we not only provide important insights into remodeling patterns of global gene expression for counteracting external stresses but also elucidate novel characteristics of the HOG pathway in\n                    <jats:italic>C. neoformans<\/jats:italic>\n                    . First, inhibition of the HOG pathway increases expression of ergosterol biosynthesis genes and cellular ergosterol content, conferring a striking synergistic antifungal activity with amphotericin B and providing an excellent opportunity to develop a novel therapeutic method for treatment of cryptococcosis. Second, a number of cadmium-sensitive genes are differentially regulated by the HOG pathway, and their mutation causes resistance to cadmium. Finally, we have discovered novel stress defense and HOG-dependent genes, which encode a sodium\/potassium efflux pump, protein kinase, multidrug transporter system, and elements of the ubiquitin-dependent system.\n                  <\/jats:p>","DOI":"10.1128\/ec.00120-09","type":"journal-article","created":{"date-parts":[[2009,6,19]],"date-time":"2009-06-19T21:45:36Z","timestamp":1245447936000},"page":"1197-1217","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":129,"title":["Remodeling of Global Transcription Patterns of\n                    <i>Cryptococcus neoformans<\/i>\n                    Genes Mediated by the Stress-Activated HOG Signaling Pathways"],"prefix":"10.1128","volume":"8","author":[{"given":"Young-Joon","family":"Ko","sequence":"first","affiliation":[{"name":"Department of Bioinformatics and Life Science, Soongsil University, Seoul, South 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