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The most common route of infection is by inhalation of airborne<jats:named-content content-type=\"genus-species\">Coccidioides<\/jats:named-content>arthroconidia. Once a susceptible host inhales the conidia, a transition to mature endosporulated spherules can occur within the first 5 days of infection. For this study, we examined the host response in a murine model of coccidioidomycosis during a time period of infection that has not been well characterized. We collected lung tissue and bronchoalveolar lavage fluid (BALF) from BALB\/c mice that were infected with a<jats:named-content content-type=\"genus-species\">C. immitis<\/jats:named-content>pure strain, a<jats:named-content content-type=\"genus-species\">C. immitis<\/jats:named-content>hybrid strain, or a<jats:named-content content-type=\"genus-species\">C. posadasii<\/jats:named-content>strain as well as uninfected mice. We compared the host responses to the<jats:named-content content-type=\"genus-species\">Coccidioides<\/jats:named-content>strains used in this study by assessing the level of transcription of selected cytokine genes in lung tissues and characterized host and fungal proteins present in BALF. Host response varied depending on the<jats:named-content content-type=\"genus-species\">Coccidioides<\/jats:named-content>strain that was used and did not appear to be overly robust. This study provides a foundation to begin to dissect the host immune response early in infection, to detect abundant<jats:named-content content-type=\"genus-species\">Coccidioides<\/jats:named-content>proteins, and to develop diagnostics that target these early time points of infection.<\/jats:p>","DOI":"10.1128\/ec.00122-15","type":"journal-article","created":{"date-parts":[[2015,8,15]],"date-time":"2015-08-15T03:24:49Z","timestamp":1439609089000},"page":"1043-1053","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":20,"title":["Differences in Host Innate Responses among Coccidioides Isolates in a Murine Model of Pulmonary Coccidioidomycosis"],"prefix":"10.1128","volume":"14","author":[{"given":"Eric R. 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