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Accordingly, antibacterial therapy raises the risk of candidiasis, yet the underlying mechanism is currently not fully understood. We hypothesize the existence of bacterial metabolites that normally control<jats:named-content content-type=\"genus-species\">C. albicans<\/jats:named-content>growth and of fungal resistance mechanisms against these metabolites. Among the most abundant microbiota-derived metabolites found on human mucosal surfaces are weak organic acids (WOAs), such as acetic, propionic, butyric, and lactic acid. Here, we used quantitative growth assays to investigate the dose-dependent fungistatic properties of WOAs on<jats:named-content content-type=\"genus-species\">C. albicans<\/jats:named-content>growth and found inhibition of growth to occur at physiologically relevant concentrations and pH values. This effect was conserved across distantly related fungal species both inside and outside the CTG clade. We next screened a library of transcription factor mutants and identified several genes required for the resistance of<jats:named-content content-type=\"genus-species\">C. albicans<\/jats:named-content>to one or more WOAs. A single gene,<jats:italic>MIG1<\/jats:italic>, previously known for its role in glucose repression, conferred resistance against all four acids tested. Consistent with glucose being an upstream activator of Mig1p, the presence of this carbon source was required for WOA resistance in wild-type<jats:named-content content-type=\"genus-species\">C. albicans<\/jats:named-content>. Conversely, a<jats:italic>MIG1<\/jats:italic>-complemented strain completely restored the glucose-dependent resistance against WOAs. We conclude that Mig1p plays a central role in orchestrating a transcriptional program to fight against the fungistatic effect of this class of highly abundant metabolites produced by the gastrointestinal tract microbiota.<\/jats:p>","DOI":"10.1128\/ec.00129-15","type":"journal-article","created":{"date-parts":[[2015,8,22]],"date-time":"2015-08-22T01:50:19Z","timestamp":1440208219000},"page":"1054-1061","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":33,"title":["<i>MIG1<\/i>Regulates Resistance of Candida albicans against the Fungistatic Effect of Weak Organic Acids"],"prefix":"10.1128","volume":"14","author":[{"given":"Fabien","family":"Cottier","sequence":"first","affiliation":[{"name":"Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alrina Shin Min","family":"Tan","sequence":"additional","affiliation":[{"name":"Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoli","family":"Xu","sequence":"additional","affiliation":[{"name":"Institute of Molecular and Cell Biology, A*STAR, Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Molecular and Cell Biology, A*STAR, Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4542-9970","authenticated-orcid":false,"given":"Norman","family":"Pavelka","sequence":"additional","affiliation":[{"name":"Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00029-06"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-03150-2_3"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhin.2009.02.009"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.0060280"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01520-08"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00218-06"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268808001763"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6968.2008.01160.x"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.55.7.1558-1563.1987"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.0040035"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.58.1.107-113.1990"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.25.2.702-707.1979"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1080\/02681218980000491"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01043-09"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/135.1.109"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365529609094568"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1155\/2008\/256490"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-11-200"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.2001.81.3.1031"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.48.4.571"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2011.01.011"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/636474"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-7753(01)72089-1"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2672.1960.tb00188.x"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/jsfa.2740600202"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1000783"},{"key":"e_1_3_3_28_2","doi-asserted-by":"crossref","first-page":"375","DOI":"10.2340\/0001555574375379","article-title":"In vivo studies concerning a pH gradient in human stratum corneum and upper epidermis","volume":"74","author":"Ohman H","year":"1994","unstructured":"Ohman H, Vahlquist A. 1994. 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