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Three of the four medically important\n            <jats:named-content content-type=\"genus-species\">Sporothrix<\/jats:named-content>\n            species found in Brazil have been considered asexual as no sexual stage has ever been reported in\n            <jats:named-content content-type=\"genus-species\">Sporothrix schenckii<\/jats:named-content>\n            ,\n            <jats:named-content content-type=\"genus-species\">Sporothrix brasiliensis<\/jats:named-content>\n            , or\n            <jats:named-content content-type=\"genus-species\">Sporothrix globosa<\/jats:named-content>\n            . We have identified the mating type (\n            <jats:italic>MAT<\/jats:italic>\n            ) loci in the\n            <jats:named-content content-type=\"genus-species\">S. schenckii<\/jats:named-content>\n            (strain 1099-18\/ATCC MYA-4821) and\n            <jats:named-content content-type=\"genus-species\">S. brasiliensis<\/jats:named-content>\n            (strain 5110\/ATCC MYA-4823) genomes by using comparative genomic approaches to determine the mating type ratio in these pathogen populations. Our analysis revealed the presence of a\n            <jats:italic>MAT1-1<\/jats:italic>\n            locus in\n            <jats:named-content content-type=\"genus-species\">S. schenckii<\/jats:named-content>\n            while a\n            <jats:italic>MAT1-2<\/jats:italic>\n            locus was found in\n            <jats:named-content content-type=\"genus-species\">S. brasiliensis<\/jats:named-content>\n            representing genomic synteny to other\n            <jats:named-content content-type=\"genus-species\">Sordariomycetes<\/jats:named-content>\n            . Furthermore, the components of the mitogen-activated protein kinase (MAPK)-pheromone pathway, pheromone processing enzymes, and meiotic regulators have also been identified in the two pathogens, suggesting the potential for sexual reproduction. The ratio of\n            <jats:italic>MAT1-1<\/jats:italic>\n            to\n            <jats:italic>MAT1-2<\/jats:italic>\n            was not significantly different from 1:1 for all three\n            <jats:named-content content-type=\"genus-species\">Sporothrix<\/jats:named-content>\n            species, but the population of\n            <jats:named-content content-type=\"genus-species\">S. brasiliensis<\/jats:named-content>\n            in the outbreaks originated from a single mating type. We also explored the population genetic structure of these pathogens using sequence data of two loci to improve our knowledge of the pattern of geographic distribution, genetic variation, and virulence phenotypes. Population genetics data showed significant population differentiation and clonality with a low level of haplotype diversity in\n            <jats:named-content content-type=\"genus-species\">S. brasiliensis<\/jats:named-content>\n            isolates from different regions of sporotrichosis outbreaks in Brazil. In contrast,\n            <jats:named-content content-type=\"genus-species\">S. schenckii<\/jats:named-content>\n            isolates demonstrated a high degree of genetic variability without significant geographic differentiation, indicating the presence of recombination. This study demonstrated that two species causing the same disease have contrasting reproductive strategies and genetic variability patterns.\n          <\/jats:p>","DOI":"10.1128\/ec.00153-14","type":"journal-article","created":{"date-parts":[[2014,12,6]],"date-time":"2014-12-06T06:33:53Z","timestamp":1417847633000},"page":"158-169","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":57,"title":["Asexual Propagation of a Virulent Clone Complex in a Human and Feline Outbreak of Sporotrichosis"],"prefix":"10.1128","volume":"14","author":[{"given":"Marcus de Melo","family":"Teixeira","sequence":"first","affiliation":[{"name":"Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade de Bras\u00edlia, Bras\u00edlia, DF, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0891-4563","authenticated-orcid":false,"given":"Anderson Messias","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Departamento de Microbiologia, Imunologia e Parasitologia, Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clement K. 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