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Isoprenoid synthesis via the methylerythritol phosphate (MEP) pathway represents an attractive target for the development of new antimalarials. The phosphonic acid antibiotic fosmidomycin is a specific inhibitor of isoprenoid synthesis and has been a helpful tool to outline the essential functions of isoprenoid biosynthesis in\n            <jats:named-content content-type=\"genus-species\">P. falciparum<\/jats:named-content>\n            . Isoprenoids are a large, diverse class of hydrocarbons that function in a variety of essential cellular processes in eukaryotes. In\n            <jats:named-content content-type=\"genus-species\">P. falciparum<\/jats:named-content>\n            , isoprenoids are used for tRNA isopentenylation and protein prenylation, as well as the synthesis of vitamin E, carotenoids, ubiquinone, and dolichols. Recently, isoprenoid synthesis in\n            <jats:named-content content-type=\"genus-species\">P. falciparum<\/jats:named-content>\n            has been shown to be regulated by a sugar phosphatase. We outline what is known about isoprenoid function and the regulation of isoprenoid synthesis in\n            <jats:named-content content-type=\"genus-species\">P. falciparum<\/jats:named-content>\n            , in order to identify valuable directions for future research.\n          <\/jats:p>","DOI":"10.1128\/ec.00160-14","type":"journal-article","created":{"date-parts":[[2014,9,13]],"date-time":"2014-09-13T01:47:21Z","timestamp":1410572841000},"page":"1348-1359","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":78,"title":["Isoprenoid Biosynthesis in Plasmodium falciparum"],"prefix":"10.1128","volume":"13","author":[{"given":"Ann M.","family":"Guggisberg","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel 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