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This ability is also essential for\n                    <jats:named-content content-type=\"genus-species\">Cryptococcus neoformans<\/jats:named-content>\n                    and its sibling species\n                    <jats:named-content content-type=\"genus-species\">Cryptococcus gattii<\/jats:named-content>\n                    , as these pathogens have saprobic and parasitic life cycles in natural and animal host environments. The ability of\n                    <jats:named-content content-type=\"genus-species\">Cryptococcus<\/jats:named-content>\n                    to cause fatal meningoencephalitis is highly related to its capability to remodel and optimize its metabolic and physiological status according to external cues. These cues act through multiple stress signaling pathways through a panoply of signaling components, including receptors\/sensors, small GTPases, secondary messengers, kinases, transcription factors, and other miscellaneous adaptors or regulators. In this minireview, we summarize and highlight the importance of several stress signaling pathways that influence the pathogenicity of\n                    <jats:named-content content-type=\"genus-species\">Cryptococcus<\/jats:named-content>\n                    and discuss future challenges in these areas.\n                  <\/jats:p>","DOI":"10.1128\/ec.00218-13","type":"journal-article","created":{"date-parts":[[2013,9,28]],"date-time":"2013-09-28T00:41:10Z","timestamp":1380328870000},"page":"1564-1577","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":83,"title":["Stress Signaling Pathways for the Pathogenicity of Cryptococcus"],"prefix":"10.1128","volume":"12","author":[{"given":"Yong-Sun","family":"Bahn","sequence":"first","affiliation":[{"name":"Department of Biotechnology, Center for Fungal Pathogenesis, College of Life Science and Biotechnology, Yonsei University, Seoul, South 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