{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T09:23:22Z","timestamp":1790501002655,"version":"4.1.0"},"reference-count":87,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Eukaryot Cell"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:named-content content-type=\"genus-species\">Fusarium graminearum<\/jats:named-content>\n                    , a prominent fungal pathogen that infects major cereal crops, primarily utilizes asexual spores to spread disease. To understand the molecular mechanisms underlying conidiogenesis in\n                    <jats:named-content content-type=\"genus-species\">F. graminearum<\/jats:named-content>\n                    , we functionally characterized the\n                    <jats:named-content content-type=\"genus-species\">F. graminearum<\/jats:named-content>\n                    ortholog of\n                    <jats:named-content content-type=\"genus-species\">Aspergillus nidulans<\/jats:named-content>\n                    <jats:italic>wetA<\/jats:italic>\n                    , which has been shown to be involved in conidiogenesis and conidium maturation. Deletion of\n                    <jats:named-content content-type=\"genus-species\">F. graminearum<\/jats:named-content>\n                    <jats:italic>wetA<\/jats:italic>\n                    did not alter mycelial growth, sexual development, or virulence, but the\n                    <jats:italic>wetA<\/jats:italic>\n                    deletion mutants produced longer conidia with fewer septa, and the conidia were sensitive to acute stresses, such as oxidative stress and heat stress. Furthermore, the survival rate of aged conidia from the\n                    <jats:named-content content-type=\"genus-species\">F. graminearum<\/jats:named-content>\n                    <jats:italic>wetA<\/jats:italic>\n                    deletion mutants was reduced. The\n                    <jats:italic>wetA<\/jats:italic>\n                    deletion resulted in vigorous generation of single-celled conidia through autophagy-dependent microcycle conidiation, indicating that WetA functions to maintain conidial dormancy by suppressing microcycle conidiation in\n                    <jats:named-content content-type=\"genus-species\">F. graminearum<\/jats:named-content>\n                    . Transcriptome analyses demonstrated that most of the putative conidiation-related genes are expressed constitutively and that only a few genes are specifically involved in\n                    <jats:named-content content-type=\"genus-species\">F. graminearum<\/jats:named-content>\n                    conidiogenesis. The conserved and distinct roles identified for WetA in\n                    <jats:named-content content-type=\"genus-species\">F. graminearum<\/jats:named-content>\n                    provide new insights into the genetics of conidiation in filamentous fungi.\n                  <\/jats:p>","DOI":"10.1128\/ec.00220-13","type":"journal-article","created":{"date-parts":[[2013,11,1]],"date-time":"2013-11-01T22:05:22Z","timestamp":1383343522000},"page":"87-98","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":71,"title":["WetA Is Required for Conidiogenesis and Conidium Maturation in the Ascomycete Fungus Fusarium graminearum"],"prefix":"10.1128","volume":"13","author":[{"given":"Hokyoung","family":"Son","sequence":"first","affiliation":[{"name":"Department of Agricultural Biotechnology and Center for Fungal Pathogenesis, Seoul National University, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myung-Gu","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Agricultural Biotechnology and Center for Fungal Pathogenesis, Seoul National University, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyunghun","family":"Min","sequence":"additional","affiliation":[{"name":"Department of Agricultural Biotechnology and Center for Fungal Pathogenesis, Seoul National University, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Yun","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Agricultural Biotechnology and Center for Fungal Pathogenesis, Seoul National University, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gyung Ja","family":"Choi","sequence":"additional","affiliation":[{"name":"Eco-friendly New Materials Research Group, Research Center for Biobased Chemistry, Division of Convergence Chemistry, Korea Research Institute of Chemical Technology, Daejeon, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Cheol","family":"Kim","sequence":"additional","affiliation":[{"name":"Eco-friendly New Materials Research Group, Research Center for Biobased Chemistry, Division of Convergence Chemistry, Korea Research Institute of Chemical Technology, Daejeon, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suhn-Kee","family":"Chae","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Paichai University, Daejeon, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin-Won","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Agricultural Biotechnology and Center for Fungal Pathogenesis, Seoul National University, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","first-page":"263","volume-title":"The Mycota","author":"Fischer R","year":"2006","unstructured":"FischerRK\u00fcesU. 2006. Asexual sporulation in mycelial fungi, p 263\u2013292. In K\u00fcesUFischerR (ed), The Mycota, 2nd ed, vol 1. Growth, differentiation and sexuality . Springer, Berlin, Germany.","edition":"2"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.62.1.35-54.1998"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2012.09.006"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2010.09.007"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.044271-0"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.4489\/MYCO.2010.38.4.229"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.2000.02202.x"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.01557-10"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1078\/1438-4221-00217"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00583905"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fgb.2009.10.004"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.funbio.2011.12.003"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(88)90198-5"},{"key":"e_1_3_3_15_2","first-page":"731","article-title":"abaA controls phialide differentiation in Aspergillus nidulans","volume":"2","author":"Sewall TC","year":"1990","unstructured":"SewallTCMimsCWTimberlakeWE. 1990. abaA controls phialide differentiation in Aspergillus nidulans. Plant Cell 2:731\u2013739.","journal-title":"Plant Cell"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(89)90800-3"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/mcb.11.1.55-62.1991"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1155888"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0000970"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2006.05447.x"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.00129-07"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.01830-10"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2010.07263.x"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002542"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2012.08083.x"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.12082"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0028291"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.059188-0"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/9780470278376"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijfoodmicro.2007.07.024"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1364-3703.2004.00252.x"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1364-3703.2011.00762.x"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.2307\/3761794"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.3852\/mycologia.97.1.229"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002310"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002460"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1094\/MPMI-23-5-0566"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1094\/MPMI-10-10-0233"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fgb.2008.01.007"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1128\/EC.00104-12"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1094\/MPMI-03-10-0075"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0072915"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0045432"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1128\/EC.05071-11"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.2007\/012260-0"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fgb.2012.05.006"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1094\/PHYTO.1999.89.2.182"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fgb.2010.01.005"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.2003.03694.x"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.2307\/3756895"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.3852\/mycologia.97.4.880"},{"key":"e_1_3_3_52_2","volume-title":"Molecular cloning: a laboratory manual","author":"Sambrook J","year":"2001","unstructured":"SambrookJRussellDW. 2001. Molecular cloning: a laboratory manual, 3rd ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.","edition":"3"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkq1016"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fgb.2011.01.002"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fgb.2004.08.001"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.1094\/MPMI.2001.14.4.580"},{"key":"e_1_3_3_57_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.71.4.1701-1708.2005"},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2006.05557.x"},{"key":"e_1_3_3_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.micres.2012.04.001"},{"key":"e_1_3_3_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5320(69)90033-1"},{"key":"e_1_3_3_61_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.17.1.208"},{"key":"e_1_3_3_62_2","doi-asserted-by":"publisher","DOI":"10.1094\/MPMI-06-12-0149-R"},{"key":"e_1_3_3_63_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gks1193"},{"key":"e_1_3_3_64_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.1226"},{"key":"e_1_3_3_65_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkm758"},{"key":"e_1_3_3_66_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkp1019"},{"key":"e_1_3_3_67_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-10-202"},{"key":"e_1_3_3_68_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.139.3.729"},{"key":"e_1_3_3_69_2","doi-asserted-by":"publisher","DOI":"10.1099\/00221287-147-7-1851"},{"key":"e_1_3_3_70_2","doi-asserted-by":"publisher","DOI":"10.4161\/auto.18705"},{"key":"e_1_3_3_71_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkr875"},{"key":"e_1_3_3_72_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkh894"},{"key":"e_1_3_3_73_2","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(90)90215-5"},{"key":"e_1_3_3_74_2","first-page":"577","volume-title":"Cellular and molecular biology of filamentous fungi","author":"Ebbole DJ","year":"2010","unstructured":"EbboleDJ. 2010. The conidium, p 577\u2013590. In BorkovichKAEbboleDJ (ed), Cellular and molecular biology of filamentous fungi. ASM Press, Washington, DC."},{"key":"e_1_3_3_75_2","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/148.3.1031"},{"key":"e_1_3_3_76_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1152398"},{"key":"e_1_3_3_77_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.0020398"},{"key":"e_1_3_3_78_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02268539"},{"key":"e_1_3_3_79_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00328694"},{"key":"e_1_3_3_80_2","doi-asserted-by":"publisher","DOI":"10.1080\/13693780801961352"},{"key":"e_1_3_3_81_2","doi-asserted-by":"publisher","DOI":"10.1099\/00221287-137-9-2103"},{"key":"e_1_3_3_82_2","doi-asserted-by":"publisher","DOI":"10.1094\/PHYTO.2003.93.2.193"},{"key":"e_1_3_3_83_2","doi-asserted-by":"publisher","DOI":"10.3852\/mycologia.99.1.1"},{"key":"e_1_3_3_84_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fgb.2008.10.010"},{"key":"e_1_3_3_85_2","doi-asserted-by":"publisher","DOI":"10.1128\/EC.01.1.11-21.2002"},{"key":"e_1_3_3_86_2","doi-asserted-by":"publisher","DOI":"10.4161\/auto.21274"},{"key":"e_1_3_3_87_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.02920-05"},{"key":"e_1_3_3_88_2","doi-asserted-by":"publisher","DOI":"10.1128\/EC.00048-09"}],"container-title":["Eukaryotic Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/EC.00220-13","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/EC.00220-13","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,23]],"date-time":"2022-02-23T10:03:45Z","timestamp":1645610625000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/EC.00220-13"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1]]},"references-count":87,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,1]]}},"alternative-id":["10.1128\/EC.00220-13"],"URL":"https:\/\/doi.org\/10.1128\/ec.00220-13","relation":{},"ISSN":["1535-9778","1535-9786"],"issn-type":[{"value":"1535-9778","type":"print"},{"value":"1535-9786","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1]]},"assertion":[{"value":"2013-08-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-10-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-01-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}