{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:09:30Z","timestamp":1791504570473,"version":"4.3.4"},"reference-count":37,"publisher":"American Society for Microbiology","issue":"11","license":[{"start":{"date-parts":[[2009,11,1]],"date-time":"2009-11-01T00:00:00Z","timestamp":1257033600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Eukaryot Cell"],"published-print":{"date-parts":[[2009,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Cryptococcus neoformans<\/jats:italic>\n                    cells must cross the blood-brain barrier prior to invading the central nervous system. Here we demonstrate that the immortalized human brain endothelial cell line HCMEC\/D3 is a useful alternative to primary brain endothelial cells as a model of the blood-brain barrier for studies of central nervous system infection.\n                  <\/jats:p>","DOI":"10.1128\/ec.00240-09","type":"journal-article","created":{"date-parts":[[2009,9,18]],"date-time":"2009-09-18T21:44:12Z","timestamp":1253310252000},"page":"1803-1807","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":124,"title":["Immortalized Human Brain Endothelial Cell Line HCMEC\/D3 as a Model of the Blood-Brain Barrier Facilitates In Vitro Studies of Central Nervous System Infection by\n                    <i>Cryptococcus neoformans<\/i>"],"prefix":"10.1128","volume":"8","author":[{"given":"Kiem","family":"Vu","sequence":"first","affiliation":[{"name":"Department of Pharmacology, School of Medicine, University of California, Genome and Biomedical Sciences Facility, Davis, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Babette","family":"Weksler","sequence":"additional","affiliation":[{"name":"Division of Hematology-Medical Oncology, Weill Medical College of Cornell University, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio","family":"Romero","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, The Open University, Walton Hall, Milton Keynes, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre-Olivier","family":"Couraud","sequence":"additional","affiliation":[{"name":"Institut Cochin, Centre National de la Recherche Scientifique UMR 8104, Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale (INSERM) U567, Universite\u0301 Rene\u0301 Descartes, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angie","family":"Gelli","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Medicine, University of California, Genome and Biomedical Sciences Facility, Davis, California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12613748"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.2165\/00023210-200721040-00004"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00089-06"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.72.9.4985-4995.2004"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)62265-1"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1051\/medsci\/2005218-9685"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01065-08"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.05230-0"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1086\/341564"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1173196"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jcbfm.9600525"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2008.11.001"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.2302\/kjm.45.183"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2007.146852"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1167\/ivos.02-0852"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.08-121624"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/EC.00120-07"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2008.01172.x"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2008.01128.x"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2007.03.100"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/0197-0186(93)90098-P"},{"key":"e_1_3_2_23_2","first-page":"207","volume":"81","year":"1993","unstructured":"Jo\u00f3, F. 1993. 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