{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T21:36:06Z","timestamp":1793828166670,"version":"4.6.1"},"reference-count":50,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2011,3,1]],"date-time":"2011-03-01T00:00:00Z","timestamp":1298937600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Eukaryot Cell"],"published-print":{"date-parts":[[2011,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            The cryptococcus-specific protein antiphagocytic protein 1 (App1) regulates\n            <jats:named-content content-type=\"genus-species\">Cryptococcus neoformans<\/jats:named-content>\n            virulence by controlling macrophage-driven fungal phagocytosis. This is accomplished through complement receptors (CR), specifically CR3. When inhaled,\n            <jats:named-content content-type=\"genus-species\">C. neoformans<\/jats:named-content>\n            can cause a life-threatening meningoencephalitis in immunocompromised patients. Because glucose starvation can significantly change the gene expression and virulence of\n            <jats:named-content content-type=\"genus-species\">C. neoformans<\/jats:named-content>\n            and because App1 is critical for phagocytosis in the lung\u2014a low-glucose environment\u2014we investigated the role of glucose in App1 expression. We found that App1 was upregulated dramatically under low-glucose conditions, and it was upregulated when\n            <jats:named-content content-type=\"genus-species\">C. neoformans<\/jats:named-content>\n            cells were incubated in bronchoalveolar lavage (BAL) fluid, serum, and cerebrospinal fluid, which are low-glucose environments. Characterization of App1's regulation based on mammalian lung physiology revealed that App1 is upregulated via both increases in transcription and increases in mRNA stability. Our data provide new insights regarding\n            <jats:named-content content-type=\"genus-species\">C. neoformans<\/jats:named-content>\n            adaptations to low-glucose environments.\n          <\/jats:p>","DOI":"10.1128\/ec.00252-10","type":"journal-article","created":{"date-parts":[[2011,1,15]],"date-time":"2011-01-15T03:08:46Z","timestamp":1295060926000},"page":"293-301","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":30,"title":["Role of Glucose in the Expression of Cryptococcus neoformans Antiphagocytic Protein 1, App1"],"prefix":"10.1128","volume":"10","author":[{"given":"Virginia","family":"Williams","sequence":"first","affiliation":[{"name":"Departments of Biochemistry &amp; Molecular Biology, Medical University of South Carolina, Charleston, South Carolina 29425"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Del Poeta","sequence":"additional","affiliation":[{"name":"Departments of Biochemistry &amp; Molecular Biology, Medical University of South Carolina, Charleston, South Carolina 29425"},{"name":"Microbiology &amp; Immunology, Medical University of South Carolina, Charleston, South Carolina 29425"},{"name":"Division of Infectious Diseases, Medical University of South Carolina, Charleston, South Carolina 29425"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.11.23.3206"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/EC.1.1.75-84.2002"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro1578"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20070311"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12038-009-0070-y"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(76)90527-3"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2009.01.056"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.169.11.4873-4877.1987"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1369-5274(99)80035-6"},{"key":"e_1_3_2_11_2","unstructured":"CasadevallA.\nPerfectJ. 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