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They have similar heteroxenous life cycles and conserved genomes and share many metabolic features. Despite these similarities,\n                    <jats:named-content content-type=\"genus-species\">T. gondii<\/jats:named-content>\n                    and\n                    <jats:named-content content-type=\"genus-species\">N. caninum<\/jats:named-content>\n                    differ in their transmission strategies and zoonotic potential. Comparative analyses of the two parasites are important to identify the unique biological features that underlie the basis of host preference and pathogenicity.\n                    <jats:named-content content-type=\"genus-species\">T. gondii<\/jats:named-content>\n                    and\n                    <jats:named-content content-type=\"genus-species\">N. caninum<\/jats:named-content>\n                    are obligate intravacuolar parasites; in contrast to\n                    <jats:named-content content-type=\"genus-species\">T. gondii<\/jats:named-content>\n                    , events that occur during\n                    <jats:named-content content-type=\"genus-species\">N. caninum<\/jats:named-content>\n                    infection remain largely uncharacterized. We examined the capability of\n                    <jats:named-content content-type=\"genus-species\">N. caninum<\/jats:named-content>\n                    (Liverpool isolate) to interact with host organelles and scavenge nutrients in comparison to that of\n                    <jats:named-content content-type=\"genus-species\">T. gondii<\/jats:named-content>\n                    (RH strain).\n                    <jats:named-content content-type=\"genus-species\">N. caninum<\/jats:named-content>\n                    reorganizes the host microtubular cytoskeleton and attracts endoplasmic reticulum (ER), mitochondria, lysosomes, multivesicular bodies, and Golgi vesicles to its vacuole though with some notable differences from\n                    <jats:named-content content-type=\"genus-species\">T. gondii<\/jats:named-content>\n                    . For example, the host ER gathers around the\n                    <jats:named-content content-type=\"genus-species\">N. caninum<\/jats:named-content>\n                    parasitophorous vacuole (PV) but does not physically associate with the vacuolar membrane; the host Golgi apparatus surrounds the\n                    <jats:named-content content-type=\"genus-species\">N. caninum<\/jats:named-content>\n                    PV but does not fragment into ministacks.\n                    <jats:named-content content-type=\"genus-species\">N. caninum<\/jats:named-content>\n                    relies on plasma lipoproteins and scavenges cholesterol from NPC1-containing endocytic organelles. This parasite salvages sphingolipids from host Golgi Rab14 vesicles that it sequesters into its vacuole. Our data highlight a remarkable degree of conservation in the intracellular infection program of\n                    <jats:named-content content-type=\"genus-species\">N. caninum<\/jats:named-content>\n                    and\n                    <jats:named-content content-type=\"genus-species\">T. gondii<\/jats:named-content>\n                    . The minor differences between the two parasites related to the recruitment and rearrangement of host organelles around their vacuoles likely reflect divergent evolutionary paths.\n                  <\/jats:p>","DOI":"10.1128\/ec.00262-14","type":"journal-article","created":{"date-parts":[[2015,3,6]],"date-time":"2015-03-06T22:03:17Z","timestamp":1425679397000},"page":"454-473","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":46,"title":["Neospora caninum Recruits Host Cell Structures to Its Parasitophorous Vacuole and Salvages Lipids from Organelles"],"prefix":"10.1128","volume":"14","author":[{"given":"Sabrina J.","family":"Nolan","sequence":"first","affiliation":[{"name":"Department of Molecular Microbiology and Immunology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia D.","family":"Romano","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology and Immunology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Luechtefeld","sequence":"additional","affiliation":[{"name":"Department of Environmental Health Sciences and Center for Alternatives to Animal Testing, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Coppens","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology and Immunology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7519(02)00094-2"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002567"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7519(00)00124-7"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/15.2.211"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-52910-7.00028-3"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0147-9571(96)00039-2"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/vr.144.24.672"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rvsc.2013.04.008"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7519(99)00132-0"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.13.1.84-89.2006"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2009.80.263"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2003.12.004"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.0030014"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.112359"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1000576"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2010.11.005"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0099744"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-78267-6_2"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2003.11.016"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0854.2004.00244.x"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2005.04483.x"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2005.04.009"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-4894(03)00137-1"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2007.09.013"},{"key":"e_1_3_3_26_2","first-page":"59","article-title":"Role of secretory dense granule organelles in the pathogenesis of toxoplasmosis","volume":"219","author":"Cesbron-Delauw MF","year":"1996","unstructured":"Cesbron-Delauw MF, Lecordier L, Mercier C. 1996. 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