{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T13:05:04Z","timestamp":1791119104993,"version":"4.1.0"},"reference-count":119,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[2002,10,1]],"date-time":"2002-10-01T00:00:00Z","timestamp":1033430400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Eukaryot Cell"],"published-print":{"date-parts":[[2002,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The unicellular green alga\n                    <jats:italic>Chlamydomonas reinhardtii<\/jats:italic>\n                    is a valuable model for studying metal metabolism in a photosynthetic background. A search of the\n                    <jats:italic>Chlamydomonas<\/jats:italic>\n                    expressed sequence tag database led to the identification of several components that form a copper-dependent iron assimilation pathway related to the high-affinity iron uptake pathway defined originally for\n                    <jats:italic>Saccharomyces cerevisiae<\/jats:italic>\n                    . They include a multicopper ferroxidase (encoded by\n                    <jats:italic>Fox1<\/jats:italic>\n                    ), an iron permease (encoded by\n                    <jats:italic>Ftr1<\/jats:italic>\n                    ), a copper chaperone (encoded by\n                    <jats:italic>Atx1<\/jats:italic>\n                    ), and a copper-transporting ATPase. A cDNA,\n                    <jats:italic>Fer1<\/jats:italic>\n                    , encoding ferritin for iron storage also was identified. Expression analysis demonstrated that\n                    <jats:italic>Fox1<\/jats:italic>\n                    and\n                    <jats:italic>Ftr1<\/jats:italic>\n                    were coordinately induced by iron deficiency, as were\n                    <jats:italic>Atx1<\/jats:italic>\n                    and\n                    <jats:italic>Fer1<\/jats:italic>\n                    , although to lesser extents. In addition, Fox1 abundance was regulated at the posttranscriptional level by copper availability. Each component exhibited sequence relationship with its yeast, mammalian, or plant counterparts to various degrees; Atx1 of\n                    <jats:italic>C. reinhardtii<\/jats:italic>\n                    is also functionally related with respect to copper chaperone and antioxidant activities. Fox1 is most highly related to the mammalian homologues hephaestin and ceruloplasmin; its occurrence and pattern of expression in\n                    <jats:italic>Chlamydomonas<\/jats:italic>\n                    indicate, for the first time, a role for copper in iron assimilation in a photosynthetic species. Nevertheless, growth of\n                    <jats:italic>C. reinhardtii<\/jats:italic>\n                    under copper- and iron-limiting conditions showed that, unlike the situation in yeast and mammals, where copper deficiency results in a secondary iron deficiency, copper-deficient\n                    <jats:italic>Chlamydomonas<\/jats:italic>\n                    cells do not exhibit symptoms of iron deficiency. We propose the existence of a copper-independent iron assimilation pathway in this organism.\n                  <\/jats:p>","DOI":"10.1128\/ec.1.5.736-757.2002","type":"journal-article","created":{"date-parts":[[2002,12,4]],"date-time":"2002-12-04T20:43:18Z","timestamp":1039034598000},"page":"736-757","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":178,"title":["Copper-Dependent Iron Assimilation Pathway in the Model Photosynthetic Eukaryote\n                    <i>Chlamydomonas reinhardtii<\/i>"],"prefix":"10.1128","volume":"1","author":[{"given":"Sharon","family":"La Fontaine","sequence":"first","affiliation":[{"name":"Department of Chemistry and Biochemistry"},{"name":"The Centre for Cellular and Molecular Biology, School of Biological and Chemical Sciences, Deakin University, Melbourne, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanette M.","family":"Quinn","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacie S.","family":"Nakamoto","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Dudley","family":"Page","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vera","family":"Go\u0308hre","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey L.","family":"Moseley","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janette","family":"Kropat","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabeeha","family":"Merchant","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry"},{"name":"Molecular Biology Institute, University of California, Los Angeles, Los Angeles, California 90095-1569"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M000713200"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1367-5931(99)80033-7"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1357-2725(99)00065-5"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/dnares\/6.6.369"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90346-8"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0968-0004(98)01192-X"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.1.401"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj3380499"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1360-1385(97)85225-9"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s000180050014"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.65.4.1762-1768.1999"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0962-8924(00)01833-X"},{"key":"e_1_3_2_14_2","unstructured":"Bucher P. and A. Bairoch. 1994. A generalized profile syntax for biomolecular sequences motifs and its function in automatic sequence interpretation p. 53-61. In R. Altman D. Brutlag P. Karp R. Lanthrop and D. Searls (ed.) ISMB-94. Proceedings of the 2nd International Conference on Intelligent Systems for Molecular Biology. AAAI Press Menlo Park Calif."},{"key":"e_1_3_2_15_2","unstructured":"Burke D. D. Dawson and T. Stearns. 2000. Methods in yeast genetics. Cold Spring Harbor Laboratory Press Cold Spring Harbor N.Y."},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M004611200"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1016710810701"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj3470749"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/35053080"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.18.11770"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/35001596"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1099\/00221287-145-9-2415"},{"key":"e_1_3_2_23_2","first-page":"1219","volume":"49","year":"1998","unstructured":"Eckhardt, U., and T. J. Buckout. 1998. Iron assimilation in Chlamydomonas reinhardtii involves ferric reduction and is similar to Strategy I higher plants. J. Exp. Bot.49:1219-1226.","journal-title":"J. Exp. Bot."},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.11.5624"},{"key":"e_1_3_2_25_2","first-page":"22","volume":"58","year":"2000","unstructured":"Eisenstein, R. S. 2000. Discovery of the ceruloplasmin homologue hephaestin: new insight into the copper\/iron connection. Nutr. Rev.58:22-26.","journal-title":"Nutr. Rev."},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(90)90238-5"},{"key":"e_1_3_2_27_2","first-page":"231","volume":"29","year":"1988","unstructured":"Esaka, M., J. Imagi, K. Suzuki, and K. Kubota. 1988. Formation of ascorbate oxidase in cultured pumpkin cells. Plant Cell Physiol.29:231-235.","journal-title":"Plant Cell Physiol."},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.3.1565"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.28.17553"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.arplant.49.1.669"},{"key":"e_1_3_2_31_2","doi-asserted-by":"crossref","unstructured":"Gietz R. D. and R. A. Woods. 1994. High efficiency transformation in yeast p. 121-134. In J. A. Johnston (ed.) Molecular genetics of yeast: practical approaches. Oxford University Press Oxford United Kingdom.","DOI":"10.1093\/oso\/9780199634309.003.0008"},{"key":"e_1_3_2_32_2","unstructured":"Grossman A. J. Davies N. Federspiel E. Harris P. Lefebvre J. P. McDermott C. Silflow D. Stern and R. Surzycki. 2000. Analyses of the Chlamydomonas reinhardtii genome: a model unicellular system for analyzing gene function and regulation in vascular plants; project phase 2."},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0005-2736(00)00138-3"},{"key":"e_1_3_2_34_2","first-page":"62","volume":"52","year":"2001","unstructured":"Guerinot, M. L., N. Grotz, S. Hibbard, E. Rogers, E. Connolly, and D. J. Eide. 2001. Molecular characterization of the uptake of iron and other divalent cations in Arabidopsis. J. Exp. Bot.52(Suppl.):62.","journal-title":"J. Exp. Bot."},{"key":"e_1_3_2_35_2","first-page":"95","volume":"41","year":"1999","unstructured":"Hall, T. A. 1999. BioEdit: a user-friendly biological sequence alignment editor and analysis program for Windows 95\/98\/NT. Nucleic Acids Symp. Ser.41:95-98.","journal-title":"Ser."},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1099\/00221287-146-4-869"},{"key":"e_1_3_2_37_2","unstructured":"Harris E. H. 1989. The chlamydomonas sourcebook: a comprehensive guide to biology and laboratory use. Academic Press San Diego Calif."},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj3510477"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.19.6730"},{"key":"e_1_3_2_40_2","first-page":"80.","volume":"52","year":"2001","unstructured":"Herbik, A., and T. J. Buckhout. 2001. Is a ferroxidase involved in the high-affinity iron uptake in Chlamydomonas? J. Exp. Bot.52(Suppl.):80.","journal-title":"J. Exp. Bot."},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6968.2000.tb09108.x"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1009252118050"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1104\/pp.112.2.697"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)98586-8"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1369-5266(00)00065-0"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1104\/pp.117.4.1227"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1093\/pcp\/41.5.548"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80747-3"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/27.1.215"},{"key":"e_1_3_2_50_2","first-page":"166.","volume":"374","year":"1993","unstructured":"Hofmann, K., and W. Stoffel. 1993. TMbase\u2014a database of membrane spanning protein segments. Biol. Chem. Hoppe-Seyler374:166.","journal-title":"Biol. Chem. Hoppe-Seyler"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1006380125438"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.70.1.677"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.3.1749"},{"key":"e_1_3_2_54_2","first-page":"712","volume":"403","year":"2000","unstructured":"Kaplan, J., and J. P. Kushner. 2000. Mining the genome for iron. Nature403:712-713.","journal-title":"Nature"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.183.16.4866-4875.2001"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.14.9221"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1099\/00221287-148-1-29"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1026438615520"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2836(82)90515-0"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)94113-X"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.176.1.173-188.1994"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.18.8222"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1099\/00221287-147-2-289"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1099\/00221287-144-12-3455"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.1994.1325"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.9.3784"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.14.9215"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004250050267"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.37.23716"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1057206"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(00)80425-6"},{"key":"e_1_3_2_72_2","doi-asserted-by":"crossref","unstructured":"Merchant S. 1997. Reciprocal copper-responsive accumulation of plastocyanin and cytochrome c6 in algae and cyanobacteria: a model for metalloregulation of metalloprotein synthesis p. 450-467. In S. Silver and W. Walden (ed.) Metal ions in gene regulation. Chapman Hall New York N.Y.","DOI":"10.1007\/978-1-4615-5993-1_17"},{"key":"e_1_3_2_73_2","doi-asserted-by":"crossref","unstructured":"Merchant S. 1998. Synthesis of metalloproteins involved in photosynthesis: plastocyanin and cytochromes p. 597-611. In J.-D. Rochaix M. Goldschmidt-Clermont and S. Merchant (ed.) Molecular biology of Chlamydomonas: chloroplasts and mitochondria. Kluwer Academic Publishers Dordrecht The Netherlands.","DOI":"10.1007\/0-306-48204-5_31"},{"key":"e_1_3_2_74_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)66641-4"},{"key":"e_1_3_2_75_2","doi-asserted-by":"publisher","DOI":"10.1128\/mcb.6.2.462-469.1986"},{"key":"e_1_3_2_76_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.arplant.49.1.25"},{"key":"e_1_3_2_77_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1991.tb07658.x"},{"key":"e_1_3_2_78_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1990.tb15311.x"},{"key":"e_1_3_2_79_2","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1046\/j.1365-313X.1992.t01-38-00999.x","volume":"2","year":"1992","unstructured":"Minet, M., M.-E. Dufour, and F. Lacroute. 1992. Complementation of Saccharomyces cerevisiae auxotrophic mutants by Arabidopsis thaliana cDNAs. Plant J.2:417-422.","journal-title":"Plant J."},{"key":"e_1_3_2_80_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/19.10.2139"},{"key":"e_1_3_2_81_2","doi-asserted-by":"publisher","DOI":"10.1093\/protein\/10.1.1"},{"key":"e_1_3_2_82_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.4.1239"},{"key":"e_1_3_2_83_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1996.tb00720.x"},{"key":"e_1_3_2_84_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M104122200"},{"key":"e_1_3_2_85_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj3590575"},{"key":"e_1_3_2_86_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.21.15041"},{"key":"e_1_3_2_87_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109220200"},{"key":"e_1_3_2_88_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5320(80)90087-8"},{"key":"e_1_3_2_89_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.278.5339.853"},{"key":"e_1_3_2_90_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(98)97020-3"},{"key":"e_1_3_2_91_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.20.14444"},{"key":"e_1_3_2_92_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.8.4481"},{"key":"e_1_3_2_93_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.288.5468.1062"},{"key":"e_1_3_2_94_2","doi-asserted-by":"publisher","DOI":"10.1038\/17800"},{"key":"e_1_3_2_95_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0969-2126(99)80082-3"},{"key":"e_1_3_2_96_2","unstructured":"Sambrook J. E. F. Fritsch and T. Maniatis. 1989. Molecular cloning: a laboratory manual 2nd ed. Cold Spring Harbor Laboratory Press Cold Spring Harbor N.Y."},{"key":"e_1_3_2_97_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00259410"},{"key":"e_1_3_2_98_2","doi-asserted-by":"publisher","DOI":"10.1097\/00075197-200007000-00005"},{"key":"e_1_3_2_99_2","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/122.1.19"},{"key":"e_1_3_2_100_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.3.1098"},{"key":"e_1_3_2_101_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.271.5255.1552"},{"key":"e_1_3_2_102_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.2.1023"},{"key":"e_1_3_2_103_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.56.070187.001445"},{"key":"e_1_3_2_104_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.9.4991"},{"key":"e_1_3_2_105_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1357-2725(99)00080-1"},{"key":"e_1_3_2_106_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M011243200"},{"key":"e_1_3_2_107_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M105857200"},{"key":"e_1_3_2_108_2","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.1995.0274"},{"key":"e_1_3_2_109_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-313X.1999.00349.x"},{"key":"e_1_3_2_110_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj3050959"},{"key":"e_1_3_2_111_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2836(92)90934-C"},{"key":"e_1_3_2_112_2","doi-asserted-by":"publisher","DOI":"10.1038\/5979"},{"key":"e_1_3_2_113_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(98)01431-8"},{"key":"e_1_3_2_114_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj3370523"},{"key":"e_1_3_2_115_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004250050495"},{"key":"e_1_3_2_116_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-313X.1996.10050835.x"},{"key":"e_1_3_2_117_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.41.25787"},{"key":"e_1_3_2_118_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.7.2632"},{"key":"e_1_3_2_119_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.14.10709"},{"key":"e_1_3_2_120_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M001456200"}],"container-title":["Eukaryotic Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/EC.1.5.736-757.2002","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/EC.1.5.736-757.2002","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,8]],"date-time":"2024-01-08T00:22:11Z","timestamp":1704673331000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/EC.1.5.736-757.2002"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,10]]},"references-count":119,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2002,10]]}},"alternative-id":["10.1128\/EC.1.5.736-757.2002"],"URL":"https:\/\/doi.org\/10.1128\/ec.1.5.736-757.2002","relation":{},"ISSN":["1535-9778","1535-9786"],"issn-type":[{"value":"1535-9778","type":"print"},{"value":"1535-9786","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,10]]},"assertion":[{"value":"2002-04-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2002-07-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2002-10-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}