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We found that\n            <jats:italic>veA<\/jats:italic>\n            , a gene previously shown to control the\n            <jats:italic>Aspergillus nidulans<\/jats:italic>\n            sexual\/asexual developmental ratio in response to light, also controls secondary metabolism. Specifically,\n            <jats:italic>veA<\/jats:italic>\n            regulates the expression of genes implicated in the synthesis of the mycotoxin sterigmatocystin and the antibiotic penicillin.\n            <jats:italic>veA<\/jats:italic>\n            is necessary for the expression of the transcription factor\n            <jats:italic>aflR<\/jats:italic>\n            , which activates the gene cluster that leads to the production of sterigmatocystin.\n            <jats:italic>veA<\/jats:italic>\n            is also necessary for penicillin production. Our results indicated that although\n            <jats:italic>veA<\/jats:italic>\n            represses the transcription of the isopenicillin synthetase gene\n            <jats:italic>ipnA<\/jats:italic>\n            , it is necessary for the expression of\n            <jats:italic>acvA<\/jats:italic>\n            , the key gene in the first step of penicillin biosynthesis, encoding the delta-(\n            <jats:sc>l<\/jats:sc>\n            -alpha-aminoadipyl)-\n            <jats:sc>l<\/jats:sc>\n            -cysteinyl-\n            <jats:sc>d<\/jats:sc>\n            -valine synthetase. With respect to the mechanism of\n            <jats:italic>veA<\/jats:italic>\n            in directing morphological development,\n            <jats:italic>veA<\/jats:italic>\n            has little effect on the expression of the known sexual transcription factors\n            <jats:italic>nsdD<\/jats:italic>\n            and\n            <jats:italic>steA<\/jats:italic>\n            . However, we found that\n            <jats:italic>veA<\/jats:italic>\n            regulates the expression of the asexual transcription factor\n            <jats:italic>brlA<\/jats:italic>\n            by modulating the \u03b1\/\u03b2 transcript ratio that controls conidiation.\n          <\/jats:p>","DOI":"10.1128\/ec.2.6.1178-1186.2003","type":"journal-article","created":{"date-parts":[[2003,12,10]],"date-time":"2003-12-10T02:17:48Z","timestamp":1071022668000},"page":"1178-1186","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":222,"title":["The Expression of Sterigmatocystin and Penicillin Genes in\n            <i>Aspergillus nidulans<\/i>\n            Is Controlled by\n            <i>veA<\/i>\n            , a Gene Required for Sexual Development"],"prefix":"10.1128","volume":"2","author":[{"given":"Naoki","family":"Kato","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, Northern Illinois University, DeKalb, Illinois 60115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilhelmina","family":"Brooks","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Northern Illinois University, DeKalb, Illinois 60115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana M.","family":"Calvo","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Northern Illinois University, DeKalb, Illinois 60115"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2621.1981.tb14549.x"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(88)90198-5"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.62.1.35-54.1998"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00452829"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.62.3.547-585.1998"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.174.11.3789-3799.1992"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.4.1418"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1094\/MPMI.1997.10.3.380"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/17.14.3990"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/153.2.715"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M100732200"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.65.8.3668-3673.1999"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.66.3.447-459.2002"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.171.7.3982-3988.1989"},{"key":"e_1_3_2_16_2","first-page":"1383","volume":"133","year":"1987","unstructured":"Champe, S. 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