{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T17:19:06Z","timestamp":1788455946104,"version":"build-2803163510"},"reference-count":9,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[2014,9,4]],"date-time":"2014-09-04T00:00:00Z","timestamp":1409788800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"},{"start":{"date-parts":[[2014,10,30]],"date-time":"2014-10-30T00:00:00Z","timestamp":1414627200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Genome Announc"],"published-print":{"date-parts":[[2014,10,30]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:named-content content-type=\"genus-species\">Haemophilus parasuis<\/jats:named-content>is a normal commensal of the upper respiratory tract of healthy pigs. However, in conjunction with stress and\/or viral infections, or in immunocompromised animals,<jats:named-content content-type=\"genus-species\">H. parasuis<\/jats:named-content>can transform into a pathogen causing Glasser's disease, which is typically characterized by fibrinous polyserositis, polyarthritis, meningitis, and sometimes acute pneumonia and septicemia.<jats:named-content content-type=\"genus-species\">H. parasuis<\/jats:named-content>serotype 5 is highly virulent and more frequently isolated from respiratory and systemic infection in pigs. Recently Newport Laboratories isolated highly virulent<jats:named-content content-type=\"genus-species\">H. parasuis<\/jats:named-content>serotype 4 strains from the tissues of diseased pigs. This study was undertaken to identify the genes responsible for<jats:named-content content-type=\"genus-species\">H. parasuis<\/jats:named-content>serotype 4 virulence. To achieve this objective we performed genome-wide association studies (GWAS) across two virulent and three avirulent<jats:named-content content-type=\"genus-species\">H. parasuis<\/jats:named-content>serotype 4 strains.<\/jats:p>","DOI":"10.1128\/genomea.00884-14","type":"journal-article","created":{"date-parts":[[2014,9,5]],"date-time":"2014-09-05T05:17:56Z","timestamp":1409894276000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":5,"title":["Genome-Wide Association Studies of Virulent and Avirulent Haemophilus parasuis Serotype 4 Strains"],"prefix":"10.1128","volume":"2","author":[{"given":"Paulraj K.","family":"Lawrence","sequence":"first","affiliation":[{"name":"Newport Laboratories, Inc., Worthington, Minnesota, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brittanny L.","family":"Wiener","sequence":"additional","affiliation":[{"name":"Newport Laboratories, Inc., Worthington, Minnesota, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tammy","family":"Kolander-Bremer","sequence":"additional","affiliation":[{"name":"Newport Laboratories, Inc., Worthington, Minnesota, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Russell F.","family":"Bey","sequence":"additional","affiliation":[{"name":"Newport Laboratories, Inc., Worthington, Minnesota, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas L.","family":"Stine","sequence":"additional","affiliation":[{"name":"Newport Laboratories, Inc., Worthington, Minnesota, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weerayuth","family":"Kittichotirat","sequence":"additional","affiliation":[{"name":"Systems Biology and Bioinformatics Research Group, Pilot Plant, Development and Training Institute, King Mongkut's University of Technology Thonburi, Bangkhuntien, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger E.","family":"Bumgarner","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University of Washington, Seattle, Washington, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1099\/00222615-2-1-75"},{"key":"e_1_3_2_3_2","first-page":"526","volume-title":"Diseases of Swine","author":"Nicolet J","year":"1992","unstructured":"NicoletJ . 1992. Haemophilus parasuis, p 526\u2013528. In Diseases of Swine. 7th ed. LemanAD StrawBE MengelingWL D'AllaireS TaylorDJ (ed). Iowa State Press, Ames, Iowa.","edition":"7"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.56.639"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-0813.1983.tb05960.x"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/vr.87.14.399"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.30.4.862-865.1992"},{"key":"e_1_3_2_8_2","doi-asserted-by":"crossref","first-page":"659","DOI":"10.2460\/ajvr.1992.53.05.659","article-title":"Prevalence of Haemophilus parasuis serovars among isolates from swine","volume":"53","author":"Rapp-Gabrielson VJ","year":"1992","unstructured":"Rapp-GabrielsonVJ GabrielsonDA . 1992. Prevalence of Haemophilus parasuis serovars among isolates from swine. Am. J. Vet. Res. 53:659\u2013664.","journal-title":"Am. J. Vet. 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