{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T05:22:35Z","timestamp":1776403355814,"version":"3.51.2"},"reference-count":36,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[2021,3,17]],"date-time":"2021-03-17T00:00:00Z","timestamp":1615939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100003593","name":"MCTI | Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["405520\/2018-2"],"award-info":[{"award-number":["405520\/2018-2"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"MCTI | Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["301304\/2017-3"],"award-info":[{"award-number":["301304\/2017-3"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006507","name":"Funda\u00e7\u00e3o Oswaldo Cruz","doi-asserted-by":"publisher","award":["VPPCB-007-FIO-18"],"award-info":[{"award-number":["VPPCB-007-FIO-18"]}],"id":[{"id":"10.13039\/501100006507","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006507","name":"Funda\u00e7\u00e3o Oswaldo Cruz","doi-asserted-by":"publisher","award":["VPPIS-001-FIO18"],"award-info":[{"award-number":["VPPIS-001-FIO18"]}],"id":[{"id":"10.13039\/501100006507","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006507","name":"Funda\u00e7\u00e3o Oswaldo Cruz","doi-asserted-by":"publisher","award":["PROEP-ICC 442186\/2019-3"],"award-info":[{"award-number":["PROEP-ICC 442186\/2019-3"]}],"id":[{"id":"10.13039\/501100006507","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006506","name":"Minist\u00e9rio da Sa\u00fade","doi-asserted-by":"publisher","award":["440015\/2018-9"],"award-info":[{"award-number":["440015\/2018-9"]}],"id":[{"id":"10.13039\/501100006506","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2021,3,17]]},"abstract":"<jats:p>The immunological potential of extracellular vesicles produced by Gram-negative bacteria, the so-called outer-membrane vesicles (OMVs), can be improved by genetic engineering, resulting in vesicles containing multiple immunogens. The potential of this approach for the development of a vaccine candidate for enteric fever was recently demonstrated by Gasperini and colleagues.<\/jats:p>","DOI":"10.1128\/iai.00001-21","type":"journal-article","created":{"date-parts":[[2021,2,5]],"date-time":"2021-02-05T16:46:10Z","timestamp":1612543570000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":3,"title":["The Benefits of Exporting: Engineered Extracellular Vesicles as Promising Vaccine Candidates against Enteric Fever"],"prefix":"10.1128","volume":"89","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6081-3439","authenticated-orcid":true,"given":"Marcio L.","family":"Rodrigues","sequence":"first","affiliation":[{"name":"Instituto Carlos Chagas, Funda\u00e7\u00e3o Oswaldo Cruz (Fiocruz), Curitiba, Brazil"},{"name":"Instituto de Microbiologia Paulo de G\u00f3es (IMPG), Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","volume-title":"Typhoid & paratyphoid fever","author":"Appiah GD","year":"2020","unstructured":"Appiah GD, Hughes MJ, Chatam-Stephens K. 2020. Typhoid & paratyphoid fever. Centers for Disease Control and Prevention, Atlanta, GA."},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-016-2074-1"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0000000000000479"},{"key":"e_1_3_2_5_2","volume-title":"Typhoid vaccine: what you need to know","author":"CDC","year":"2019","unstructured":"CDC. 2019. Typhoid vaccine: what you need to know. Centers for Disease Control and Prevention, Atlanta, GA."},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1080\/1040841X.2016.1249335"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-2452(97)86018-6"},{"key":"e_1_3_2_8_2","volume-title":"WHO recommends use of first typhoid conjugate vaccine","author":"World Health Organization","year":"2018","unstructured":"World Health Organization. 2018. WHO recommends use of first typhoid conjugate vaccine. World Health Organization, Geneva, Switzerland."},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2016.03.106"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6976.2002.tb00597.x"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00699-20"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/femsre\/fuy042"},{"key":"e_1_3_2_13_2","article-title":"Biological properties of extracellular vesicles and their physiological functions","author":"Y\u00e1\u00f1ez-M\u00f3 M","year":"2015","unstructured":"Y\u00e1\u00f1ez-M\u00f3 M, Siljander PRM, Andreu Z, Zavec AB, Borr\u00e0s FE, Buzas EI, Buzas K, Casal E, Cappello F, Carvalho J, Col\u00e1s E, Cordeiro-Da Silva A, Fais S, Falcon-Perez JM, Ghobrial IM, Giebel B, Gimona M, Graner M, Gursel I, Gursel M, Heegaard NHH, Hendrix A, Kierulf P, Kokubun K, Kosanovic M, Kralj-Iglic V, Kr\u00e4mer-Albers EM, Laitinen S, L\u00e4sser C, Lener T, Ligeti E, Line A, Lipps G, Llorente A, L\u00f6tvall J, Man\u010dek-Keber M, Marcilla A, Mittelbrunn M, Nazarenko I, Nolte-\u2019t Hoen ENM, Nyman TA, O\u2019Driscoll L, Olivan M, Oliveira C, P\u00e1llinger \u00c9, Del Portillo HA, Revent\u00f3s J, Rigau M, Rohde E, Sammar M, S\u00e1nchez-Madrid F, . 2015. Biological properties of extracellular vesicles and their physiological functions. J Extracell Vesicles.","journal-title":"J Extracell Vesicles"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro3525"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/biot.201400395"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri3622"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1080\/21645515.2017.1381810"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-03847-z"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.02909-18"},{"key":"e_1_3_2_20_2","article-title":"Protective effect of fungal extracellular vesicles against murine candidiasis","volume":"18","author":"Vargas G","year":"2020","unstructured":"Vargas G, Honorato L, Guimar\u00e3es AJ, Rodrigues ML, Reis FCG, Vale AM, Ray A, Nosanchuk JD, Nimrichter L. 2020. Protective effect of fungal extracellular vesicles against murine candidiasis. Cell Microbiol 18:e13238.","journal-title":"Cell Microbiol"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2020.00346"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2015.09.002"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1080\/20013078.2018.1463779"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-018-0036-9"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines8030540"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1128\/mSphere.00080-19"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0035616"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2016.11.089"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2014.03.068"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiotec.2015.01.020"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0007964"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00204"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciy001"},{"key":"e_1_3_2_34_2","doi-asserted-by":"crossref","unstructured":"Juliana R Wong SSW Gazi AD Moyrand F Chaze T Commere P-H Matondo M Novault S Pehau-Arnaudet G Reis F Vos M Alves LR May RC Nimrichter LH Rodrigues ML Aimanianda V Janbon G. 2020. New insights into Cryptococcus extracellular vesicles suggest a new structural model and an antifungal vaccine strategy. bioRxiv doi:10.1101\/2020.08.17.253716.","DOI":"10.1101\/2020.08.17.253716"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2019.00100"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12936-017-1891-z"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.5483\/bmbrep.2014.47.10.164"}],"container-title":["Infection and Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/IAI.00001-21","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/IAI.00001-21","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T13:53:57Z","timestamp":1646488437000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/IAI.00001-21"}},"subtitle":[],"editor":[{"given":"Liise-anne","family":"Pirofski","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2021,3,17]]},"references-count":36,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,3,17]]}},"alternative-id":["10.1128\/IAI.00001-21"],"URL":"https:\/\/doi.org\/10.1128\/iai.00001-21","relation":{},"ISSN":["0019-9567","1098-5522"],"issn-type":[{"value":"0019-9567","type":"print"},{"value":"1098-5522","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,17]]},"assertion":[{"value":"2021-03-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00001-21"}}