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Previous studies have shown the interaction of LOS with sialic acid-specific siglec receptors, although the functional consequences remain unknown. Cells that express high levels of siglecs include dendritic cells (DCs), which are crucial for initiation and differentiation of immune responses. We confirm that \u03b12,3-sialylated GD1a\/GM1a mimic and \u03b12,8-sialylated GD1c mimic LOS structures interact with recombinant Sn and siglec-7, respectively. Although the linkage of the terminal sialic acid of LOS did not regulate expression of DC maturation markers, it displayed clear opposite expression levels of interleukin-12 (IL-12) and OX40L, molecules involved in DC-mediated Th cell differentiation. Accordingly, targeting DC-expressed siglec-7 with \u03b12,8-linked sialylated LOS resulted in Th1 responses, whereas Th2 responses were induced by targeting with LOS containing \u03b12,3-linked sialic acid. Thus, our data demonstrate for the first time that depending on the sialylated composition of<jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Campylobacter jejuni<\/jats:named-content>LOS, specific Th differentiation programs are initiated, possibly through targeting of distinct DC-expressed siglecs.<\/jats:p>","DOI":"10.1128\/iai.00009-11","type":"journal-article","created":{"date-parts":[[2011,4,19]],"date-time":"2011-04-19T04:23:55Z","timestamp":1303187035000},"page":"2681-2689","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":76,"title":["Campylobacter jejuni Lipooligosaccharides Modulate Dendritic Cell-Mediated T Cell Polarization in a Sialic Acid Linkage-Dependent Manner"],"prefix":"10.1128","volume":"79","author":[{"given":"Marieke","family":"Bax","sequence":"first","affiliation":[{"name":"Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark L.","family":"Kuijf","sequence":"additional","affiliation":[{"name":"Departments of Neurology and Immunology, Erasmus MC, University Medical Center, Rotterdam, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Astrid P.","family":"Heikema","sequence":"additional","affiliation":[{"name":"Medical Microbiology and Infectious Diseases, Erasmus MC, University Medical Center, Rotterdam, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wouter","family":"van Rijs","sequence":"additional","affiliation":[{"name":"Departments of Neurology and Immunology, Erasmus MC, University Medical Center, Rotterdam, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven C. 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