{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T13:42:30Z","timestamp":1787060550521,"version":"build-2736575974"},"reference-count":73,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[2021,4,16]],"date-time":"2021-04-16T00:00:00Z","timestamp":1618531200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/doi.org\/10.1128\/AuthorWarrantyLicense.v1"},{"start":{"date-parts":[[2021,4,16]],"date-time":"2021-04-16T00:00:00Z","timestamp":1618531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2021,4,16]]},"abstract":"<jats:p>\n                    <jats:named-content content-type=\"genus-species\">Toxoplasma gondii<\/jats:named-content>\n                    infection activates pattern recognition receptor (PRR) pathways that drive innate inflammatory responses to control infection. Necroptosis is a proinflammatory cell death pathway apart from the innate immune response that has evolved to control pathogenic infection.\n                  <\/jats:p>","DOI":"10.1128\/iai.00021-21","type":"journal-article","created":{"date-parts":[[2021,2,2]],"date-time":"2021-02-02T12:37:45Z","timestamp":1612269465000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":28,"title":["RIPK3 Facilitates Host Resistance to Oral Toxoplasma gondii Infection"],"prefix":"10.1128","volume":"89","author":[{"given":"Patrick W.","family":"Cervantes","sequence":"first","affiliation":[{"name":"Department of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, Wisconsin, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Martorelli Di Genova","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, Wisconsin, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Billy Joel","family":"Erazo Flores","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, Wisconsin, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9362-8088","authenticated-orcid":true,"given":"Laura J.","family":"Knoll","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, Wisconsin, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.00027-15"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.a.22348"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxy004"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/pim.12164"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2009.03876.x"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.168.12.5997"},{"key":"e_1_3_3_8_2","first-page":"9S","article-title":"Role of IL-12 in the initiation of cell mediated immunity by Toxoplasma gondii and its regulation by IL-10 and nitric oxide","volume":"41","author":"Gazzinelli RT","year":"1994","unstructured":"Gazzinelli RT, Hayashi S, Wysocka M, Carrera L, Kuhn R, Muller W, Roberge F, Trinchieri G, Sher A. 1994. Role of IL-12 in the initiation of cell mediated immunity by Toxoplasma gondii and its regulation by IL-10 and nitric oxide. J Eukaryot Microbiol 41:9S.","journal-title":"J Eukaryot Microbiol"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.62.5.1639-1642.1994"},{"key":"e_1_3_3_10_2","doi-asserted-by":"crossref","first-page":"4045","DOI":"10.4049\/jimmunol.157.9.4045","article-title":"In the absence of endogenous IFN-gamma, mice develop unimpaired IL-12 responses to Toxoplasma gondii while failing to control acute infection","volume":"157","author":"Scharton-Kersten TM","year":"1996","unstructured":"Scharton-Kersten TM, Wynn TA, Denkers EY, Bala S, Grunvald E, Hieny S, Gazzinelli RT, Sher A. 1996. In the absence of endogenous IFN-gamma, mice develop unimpaired IL-12 responses to Toxoplasma gondii while failing to control acute infection. J Immunol 157:4045\u20134054.","journal-title":"J Immunol"},{"key":"e_1_3_3_11_2","first-page":"827","article-title":"Interferon-gamma receptor-deficiency renders mice highly susceptible to toxoplasmosis by decreased macrophage activation","volume":"75","author":"Deckert-Schl\u00fcter M","year":"1996","unstructured":"Deckert-Schl\u00fcter M, Rang A, Weiner D, Huang S, Wiestler OD, Hof H, Schl\u00fcter D. 1996. Interferon-gamma receptor-deficiency renders mice highly susceptible to toxoplasmosis by decreased macrophage activation. Lab Investig 75:827\u2013841.","journal-title":"Lab Investig"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00024-19"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00933779"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.164.10.5375"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20041789"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.184.2.597"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3024.1999.00237.x"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200424993"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2016.147"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02379"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2013.02.003"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12287"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-15-806"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00511-16"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2012.01.016"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aag2045"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-019-0237-x"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/embor.2009.109"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2019.09.004"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2017.11.002"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.05.021"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.05.037"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2016.09.014"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2016.05.011"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.07.039"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2018.02283"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-018-1606-4"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2017.11.054"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0176144"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.12.8785"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0105120"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0108389"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2018.01.001"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.2307\/3284282"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01126-12"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182097001959"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/bs.ircmb.2016.08.007"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2014.03.003"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/6152489"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmicrobiol.2016.258"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature06013"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0801295105"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.187.9.1477"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1172308"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.180.9.5771"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2006.104497"},{"key":"e_1_3_3_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2009.06.005"},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2008.01.001"},{"key":"e_1_3_3_59_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01170-13"},{"key":"e_1_3_3_60_2","doi-asserted-by":"publisher","DOI":"10.3347\/kjp.2016.54.6.711"},{"key":"e_1_3_3_61_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1613305114"},{"key":"e_1_3_3_62_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms7282"},{"key":"e_1_3_3_63_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.2000159"},{"key":"e_1_3_3_64_2","first-page":"107","article-title":"Blockade of IL-1R signaling diminishes Paneth cell depletion and Toxoplasma gondii induced ileitis in mice","volume":"2","author":"Villeret B","year":"2013","unstructured":"Villeret B, Brault L, Couturier-Maillard A, Robinet P, Vasseur V, Secher T, Dimier-Poisson I, Jacobs M, Zheng SG, Quesniaux VF, Ryffel B. 2013. Blockade of IL-1R signaling diminishes Paneth cell depletion and Toxoplasma gondii induced ileitis in mice. Am J Clin Exp Immunol 2:107\u2013116.","journal-title":"Am J Clin Exp Immunol"},{"key":"e_1_3_3_65_2","doi-asserted-by":"publisher","DOI":"10.1086\/653738"},{"key":"e_1_3_3_66_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01117-13"},{"key":"e_1_3_3_67_2","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/9848263"},{"key":"e_1_3_3_68_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1007872"},{"key":"e_1_3_3_69_2","doi-asserted-by":"publisher","DOI":"10.1128\/mcb.24.4.1464-1469.2004"},{"key":"e_1_3_3_70_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2013.06.018"},{"key":"e_1_3_3_71_2","doi-asserted-by":"publisher","DOI":"10.3791\/2091"},{"key":"e_1_3_3_72_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2008.07.012"},{"key":"e_1_3_3_73_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3000364"},{"key":"e_1_3_3_74_2","first-page":"634","article-title":"Comparison of PCR detection methods for B1, P30, and 18S rDNA genes of T. gondii in aqueous humor","volume":"41","author":"Jones CD","year":"2000","unstructured":"Jones CD, Okhravi N, Adamson P, Tasker S, Lightman S. 2000. Comparison of PCR detection methods for B1, P30, and 18S rDNA genes of T. gondii in aqueous humor. Investig Ophthalmol Vis Sci 41:634\u2013644.","journal-title":"Investig Ophthalmol Vis Sci"}],"container-title":["Infection and Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/IAI.00021-21","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/IAI.00021-21","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T20:55:55Z","timestamp":1697748955000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/IAI.00021-21"}},"subtitle":[],"editor":[{"given":"Jeroen P. J.","family":"Saeij","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2021,4,16]]},"references-count":73,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,4,16]]}},"alternative-id":["10.1128\/IAI.00021-21"],"URL":"https:\/\/doi.org\/10.1128\/iai.00021-21","relation":{},"ISSN":["0019-9567","1098-5522"],"issn-type":[{"value":"0019-9567","type":"print"},{"value":"1098-5522","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,16]]},"assertion":[{"value":"2021-01-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00021-21"}}