{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:04:11Z","timestamp":1791821051251,"version":"4.3.4"},"reference-count":88,"publisher":"American Society for Microbiology","issue":"7","license":[{"start":{"date-parts":[[2022,7,21]],"date-time":"2022-07-21T00:00:00Z","timestamp":1658361600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/doi.org\/10.1128\/ASMCopyrightv2"},{"start":{"date-parts":[[2022,7,21]],"date-time":"2022-07-21T00:00:00Z","timestamp":1658361600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2022,7,21]]},"abstract":"<jats:p>5-Lipoxygenase (5-LO) is an enzyme required for the production of leukotrienes and lipoxins and interferes with parasitic infections.<jats:italic>In vitro<\/jats:italic>,<jats:named-content content-type=\"genus-species\">Toxoplasma gondii<\/jats:named-content>inhibits leukotriene B<jats:sub>4<\/jats:sub>(LTB<jats:sub>4<\/jats:sub>) production, and mice deficient in 5-LO are highly susceptible to infection. The aim of this study was to investigate the effects of the pharmacological inhibition of the 5-LO pathway and exogenous LTB<jats:sub>4<\/jats:sub>supplementation during experimental toxoplasmosis.<\/jats:p>","DOI":"10.1128\/iai.00029-22","type":"journal-article","created":{"date-parts":[[2022,6,6]],"date-time":"2022-06-06T13:01:46Z","timestamp":1654520506000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":3,"title":["Toxoplasma gondii Infection Decreases Intestinal 5-Lipoxygenase Expression, while Exogenous LTB<sub>4<\/sub>Controls Parasite Growth"],"prefix":"10.1128","volume":"90","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7053-6757","authenticated-orcid":true,"given":"Ester Cristina Borges","family":"Araujo","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio de Imunopatologia, Instituto de Ci\u00eancias Biom\u00e9dicas, Universidade Federal de Uberl\u00e2ndia, Uberl\u00e2ndia, Minas Gerais, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marisol Patricia Pallete","family":"Brice\u00f1o","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Imunopatologia, Instituto de Ci\u00eancias Biom\u00e9dicas, Universidade Federal de Uberl\u00e2ndia, Uberl\u00e2ndia, Minas Gerais, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3473-3555","authenticated-orcid":true,"given":"Yusmaris","family":"Cariaco","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Imunopatologia, Instituto de Ci\u00eancias Biom\u00e9dicas, Universidade Federal de Uberl\u00e2ndia, Uberl\u00e2ndia, Minas Gerais, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1rio C\u00e9zar","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Imunopatologia, Instituto de Ci\u00eancias Biom\u00e9dicas, Universidade Federal de Uberl\u00e2ndia, Uberl\u00e2ndia, Minas Gerais, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3835-1925","authenticated-orcid":true,"given":"Marcos Paulo Oliveira","family":"Almeida","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Imunopatologia, Instituto de Ci\u00eancias Biom\u00e9dicas, Universidade Federal de Uberl\u00e2ndia, Uberl\u00e2ndia, Minas Gerais, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nat\u00e1lia Carnevalli","family":"de Miranda","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Imunopatologia, Instituto de Ci\u00eancias Biom\u00e9dicas, Universidade Federal de Uberl\u00e2ndia, Uberl\u00e2ndia, Minas Gerais, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3615-1340","authenticated-orcid":true,"given":"Neide Maria","family":"Silva","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Imunopatologia, Instituto de Ci\u00eancias Biom\u00e9dicas, Universidade Federal de Uberl\u00e2ndia, Uberl\u00e2ndia, Minas Gerais, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)36026-5"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2010.02.173"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0952-3278(03)00070-X"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.4.857"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/343278a0"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.6301011"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2017.08.006"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.advenzreg.2010.08.002"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2020.104857"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1100\/tsw.2010.113"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2018-0175OC"},{"key":"e_1_3_2_13_2","first-page":"667","article-title":"Effect of 5-lipoxygenase inhibition on events associated with inflammatory bowel disease in rats","volume":"42","author":"Singh VP","year":"2004","unstructured":"Singh VP, Patil CS, Kulkarni SK. 2004. Effect of 5-lipoxygenase inhibition on events associated with inflammatory bowel disease in rats. Indian J Exp Biol 42:667\u2013673.","journal-title":"Indian J Exp Biol"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.3700276"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2020.04.011"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1001258"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1700544"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2020.03.022"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/JLB.MA1218-477RR"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0031701"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2007.01.006"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.6.3892"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2010.03.016"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20021183"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0075138"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16412-X"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01722-14"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/pim.12712"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.184.2.597"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.164.10.5375"},{"key":"e_1_3_2_31_2","doi-asserted-by":"crossref","first-page":"798","DOI":"10.4049\/jimmunol.157.2.798","article-title":"In the absence of endogenous IL-10, mice acutely infected with Toxoplasma gondii succumb to a lethal immune response dependent on CD4+ T cells and accompanied by overproduction of IL-12, IFN-gamma and TNF-alpha","volume":"157","author":"Gazzinelli RT","year":"1996","unstructured":"Gazzinelli RT, Wysocka M, Hieny S, Scharton-Kersten T, Cheever A, K\u00fchn R, M\u00fcller W, Trinchieri G, Sher A. 1996. In the absence of endogenous IL-10, mice acutely infected with Toxoplasma gondii succumb to a lethal immune response dependent on CD4+ T cells and accompanied by overproduction of IL-12, IFN-gamma and TNF-alpha. J Immunol 157:798\u2013805.","journal-title":"J Immunol"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.180.5.1637"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1086\/314619"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2017.07.019"},{"key":"e_1_3_2_35_2","doi-asserted-by":"crossref","first-page":"3438","DOI":"10.4049\/jimmunol.145.10.3438","article-title":"Class I MHC genes and CD8+ T cells determine cyst number in Toxoplasma gondii infection","volume":"145","author":"Brown CR","year":"1990","unstructured":"Brown CR, McLeod R. 1990. Class I MHC genes and CD8+ T cells determine cyst number in Toxoplasma gondii infection. J Immunol 145:3438\u20133441.","journal-title":"J Immunol"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.micro.51.1.311"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1097\/MOG.0b013e3283506559"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.11.2.267"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.02592-14"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1202932"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.imbio.2016.11.010"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.2307\/3284069"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1590\/s0100-879x2010007500053"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.72.3.1637-1644.2004"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/5091630"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0002390"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/264270"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.3128869"},{"key":"e_1_3_2_49_2","first-page":"827","article-title":"Interferon-gamma receptor-deficiency renders mice highly susceptible to toxoplasmosis by decreased macrophage activation","volume":"75","author":"Deckert-Schl\u00fcter M","year":"1996","unstructured":"Deckert-Schl\u00fcter M, Rang A, Weiner D, Huang S, Wiestler OD, Hof H, Schl\u00fcter D. 1996. Interferon-gamma receptor-deficiency renders mice highly susceptible to toxoplasmosis by decreased macrophage activation. Lab Invest 75:827\u2013841.","journal-title":"Lab Invest"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.65.6.2339-2345.1997"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3024.1998.00152.x"},{"key":"e_1_3_2_52_2","doi-asserted-by":"crossref","first-page":"3427","DOI":"10.4049\/jimmunol.160.7.3427","article-title":"Crucial role of TNF receptor type 1 (p55), but not of TNF receptor type 2 (p75), in murine toxoplasmosis","volume":"160","author":"Deckert-Schl\u00fcter M","year":"1998","unstructured":"Deckert-Schl\u00fcter M, Bluethmann H, Rang A, Hof H, Schl\u00fcter D. 1998. Crucial role of TNF receptor type 1 (p55), but not of TNF receptor type 2 (p75), in murine toxoplasmosis. J Immunol 160:3427\u20133436.","journal-title":"J Immunol"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0121402"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.3858\/emm.2008.40.4.461"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2017.08.022"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000140063.06341.09"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.1998.274.6.L1030"},{"key":"e_1_3_2_58_2","doi-asserted-by":"crossref","first-page":"3958","DOI":"10.4049\/jimmunol.135.6.3958","article-title":"Leukotrienes augment interleukin 1 production by human monocytes","volume":"135","author":"Rola-Pleszczynski M","year":"1985","unstructured":"Rola-Pleszczynski M, Lemaire I. 1985. Leukotrienes augment interleukin 1 production by human monocytes. J Immunol 135:3958\u20133961.","journal-title":"J Immunol"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V80.4.1004.1004"},{"key":"e_1_3_2_60_2","doi-asserted-by":"crossref","first-page":"4041","DOI":"10.4049\/jimmunol.150.9.4041","article-title":"Priming of human monocytes with leukotriene B4 enhances their sensitivity in IL-2-driven tumor necrosis factor-alpha production. Transcriptional and post-transcriptional up-regulation of IL-2 receptors","volume":"150","author":"Stankov\u00e1 J","year":"1993","unstructured":"Stankov\u00e1 J, Dupuis G, Gagnon N, Thivierge M, Turcotte S, Rola-Pleszczynski M. 1993. Priming of human monocytes with leukotriene B4 enhances their sensitivity in IL-2-driven tumor necrosis factor-alpha production. Transcriptional and post-transcriptional up-regulation of IL-2 receptors. J Immunol 150:4041\u20134051.","journal-title":"J Immunol"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1016\/0262-1746(86)90187-3"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0139856"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.12.8036"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.180.9.6211"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2508"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2017.102"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2018.01.001"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-051116-052424"},{"key":"e_1_3_2_69_2","first-page":"107","article-title":"Blockade of IL-1R signaling diminishes Paneth cell depletion and Toxoplasma gondii induced ileitis in mice","volume":"2","author":"Villeret B","year":"2013","unstructured":"Villeret B, Brault L, Couturier-Maillard A, Robinet P, Vasseur V, Secher T, Dimier-Poisson I, Jacobs M, Zheng S-G, Quesniaux VF, Ryffel B. 2013. Blockade of IL-1R signaling diminishes Paneth cell depletion and Toxoplasma gondii induced ileitis in mice. Am J Clin Exp Immunol 2:107\u2013116.","journal-title":"Am J Clin Exp Immunol"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1111\/pim.12811"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms8040560"},{"key":"e_1_3_2_72_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.235309"},{"key":"e_1_3_2_73_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-08-3323"},{"key":"e_1_3_2_74_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01323-09"},{"key":"e_1_3_2_75_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.5.3201"},{"key":"e_1_3_2_76_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1007887"},{"key":"e_1_3_2_77_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.prostaglandins.2019.106390"},{"key":"e_1_3_2_78_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-17993-9"},{"key":"e_1_3_2_79_2","doi-asserted-by":"crossref","first-page":"3951","DOI":"10.4049\/jimmunol.150.9.3951","article-title":"Antibodies to Toxoplasma gondii major surface protein (SAG-1, P30) inhibit infection of host cells and are produced in murine intestine after peroral infection","volume":"150","author":"Mineo JR","year":"1993","unstructured":"Mineo JR, McLeod R, Mack D, Smith J, Khan IA, Ely KH, Kasper LH. 1993. Antibodies to Toxoplasma gondii major surface protein (SAG-1, P30) inhibit infection of host cells and are produced in murine intestine after peroral infection. J Immunol 150:3951\u20133964.","journal-title":"J Immunol"},{"key":"e_1_3_2_80_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2011.04.007"},{"key":"e_1_3_2_81_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41385-019-0175-z"},{"key":"e_1_3_2_82_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI116153"},{"key":"e_1_3_2_83_2","doi-asserted-by":"publisher","DOI":"10.2307\/3283948"},{"key":"e_1_3_2_84_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2019.00098"},{"key":"e_1_3_2_85_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exppara.2009.05.011"},{"key":"e_1_3_2_86_2","doi-asserted-by":"publisher","DOI":"10.1211\/jpp.59.9.0009"},{"key":"e_1_3_2_87_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0901642"},{"key":"e_1_3_2_88_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-49471-9"},{"key":"e_1_3_2_89_2","doi-asserted-by":"publisher","DOI":"10.1006\/meth.2001.1262"}],"container-title":["Infection and Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/iai.00029-22","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/iai.00029-22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,7]],"date-time":"2023-02-07T11:28:31Z","timestamp":1675769311000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/iai.00029-22"}},"subtitle":[],"editor":[{"given":"Jeroen P. J.","family":"Saeij","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,7,21]]},"references-count":88,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2022,7,21]]}},"alternative-id":["10.1128\/iai.00029-22"],"URL":"https:\/\/doi.org\/10.1128\/iai.00029-22","relation":{},"ISSN":["0019-9567","1098-5522"],"issn-type":[{"value":"0019-9567","type":"print"},{"value":"1098-5522","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,21]]},"assertion":[{"value":"2022-01-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00029-22"}}