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In comparison to the parental m1 VacA protein, a chimeric protein (designated m2\/m1) containing m2 sequences in the N-terminal portion of the m region was less potent in causing vacuolation of HeLa cells, AGS gastric cells, and AZ-521 duodenal cells and had reduced capacity to cause membrane depolarization or death of AZ-521 cells.\n          <\/jats:p>","DOI":"10.1128\/iai.00032-20","type":"journal-article","created":{"date-parts":[[2020,4,8]],"date-time":"2020-04-08T16:18:29Z","timestamp":1586362709000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":19,"title":["Functional Properties of Helicobacter pylori VacA Toxin m1 and m2 Variants"],"prefix":"10.1128","volume":"88","author":[{"given":"Rhonda R.","family":"Caston","sequence":"first","affiliation":[{"name":"Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee, 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