{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T18:55:58Z","timestamp":1791226558818,"version":"4.1.0"},"reference-count":41,"publisher":"American Society for Microbiology","issue":"7","license":[{"start":{"date-parts":[[2008,7,1]],"date-time":"2008-07-01T00:00:00Z","timestamp":1214870400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2008,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Human\n                    <jats:italic>Helicobacter pylori<\/jats:italic>\n                    infection gives rise to an active chronic gastritis and is a major risk factor for the development of duodenal ulcer disease and gastric adenocarcinoma. The infection is accompanied by a large accumulation of immunoglobulin A (IgA)-secreting cells in the gastric mucosa, and following mucosal immunization only\n                    <jats:italic>H. pylori<\/jats:italic>\n                    -infected volunteers mounted a B-cell response in the gastric mucosa. To identify the signals for recruitment of gastric IgA-secreting cells, we investigated the gastric production of CCL28 (mucosa-associated epithelial chemokine) and CCL25 (thymus-expressed chemokine) in\n                    <jats:italic>H. pylori<\/jats:italic>\n                    -infected and uninfected individuals and the potential of gastric B-cell populations to migrate toward these chemokines. Gastric tissue from\n                    <jats:italic>H. pylori<\/jats:italic>\n                    -infected individuals contained significantly more CCL28 protein and mRNA than that from uninfected individuals, while CCL25 levels remained unchanged. Chemokine-induced migration of gastric lamina propria lymphocytes isolated from patients undergoing gastric resection was then assessed using the Transwell system. IgA-secreting cells and IgA\n                    <jats:sup>+<\/jats:sup>\n                    memory B cells from\n                    <jats:italic>H. pylori<\/jats:italic>\n                    -infected tissues migrated toward CCL28 but not CCL25, while the corresponding cells from uninfected patients did not. Furthermore, IgG-secreting cells from\n                    <jats:italic>H. pylori<\/jats:italic>\n                    -infected patients did not migrate to CCL28 but instead to CXCL12 (SDF-1\u03b1). However, chemokine receptor expression did not correlate to the migratory pattern of the different B-cell populations. These studies are the first to show increased CCL28 production during gastrointestinal infection in humans and provide an explanation for the large influx of IgA-secreting cells to the gastric mucosa in\n                    <jats:italic>H. pylori<\/jats:italic>\n                    -infected individuals.\n                  <\/jats:p>","DOI":"10.1128\/iai.00041-08","type":"journal-article","created":{"date-parts":[[2008,4,21]],"date-time":"2008-04-21T22:42:26Z","timestamp":1208817746000},"page":"3304-3311","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":32,"title":["CCL28 Is Increased in Human\n                    <i>Helicobacter pylori<\/i>\n                    -Induced Gastritis and Mediates Recruitment of Gastric Immunoglobulin A-Secreting Cells"],"prefix":"10.1128","volume":"76","author":[{"given":"Malin","family":"Hansson","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, Institute of Biomedicine, and Go\u0308teborg University Vaccine Research Institute (GUVAX), Go\u0308teborg University, Box 435, 405 30 Go\u0308teborg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Hermansson","sequence":"additional","affiliation":[{"name":"Department of Surgery, Institute of Medicine, Sahlgrenska University Hospital, 413 45 Go\u0308teborg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena","family":"Svensson","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Institute of Biomedicine, and Go\u0308teborg University Vaccine Research Institute (GUVAX), Go\u0308teborg University, Box 435, 405 30 Go\u0308teborg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Elfvin","sequence":"additional","affiliation":[{"name":"Department of Surgery, Institute of Medicine, Sahlgrenska University Hospital, 413 45 Go\u0308teborg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars-Erik","family":"Hansson","sequence":"additional","affiliation":[{"name":"Department of Surgery, Institute of Medicine, Sahlgrenska University Hospital, 413 45 Go\u0308teborg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"Johnsson","sequence":"additional","affiliation":[{"name":"Department of Surgery, Institute of Medicine, Sahlgrenska University Hospital, 413 45 Go\u0308teborg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A\u030asa","family":"Sjo\u0308ling","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Institute of Biomedicine, and Go\u0308teborg University Vaccine Research Institute (GUVAX), Go\u0308teborg University, Box 435, 405 30 Go\u0308teborg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne","family":"Quiding-Ja\u0308rbrink","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Institute of Biomedicine, and Go\u0308teborg University Vaccine Research Institute (GUVAX), Go\u0308teborg University, Box 435, 405 30 Go\u0308teborg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1042\/CS103S450S"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-005-1611-2"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-1759(99)00213-6"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90305-A"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.bmb.a011664"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20010670"},{"key":"e_1_3_2_8_2","first-page":"97","volume":"151","year":"1997","unstructured":"Briskin, M., D. 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