{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:29:09Z","timestamp":1791217749699,"version":"4.1.0"},"reference-count":35,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[2013,5,1]],"date-time":"2013-05-01T00:00:00Z","timestamp":1367366400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Porphyromonas gingivalis<\/jats:named-content>\n            is one of the oral microorganisms associated with human chronic periodontitis. The purpose of this study is to determine the role of the receptor activator of nuclear factor-\u03baB ligand (RANKL) in\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">P. gingivalis<\/jats:named-content>\n            infection-associated periodontal bone resorption. Inbred female Rowett rats were infected orally on four consecutive days (days 0 to 3) with 1 \u00d7 10\n            <jats:sup>9<\/jats:sup>\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">P. gingivalis<\/jats:named-content>\n            bacteria (strain ATCC 33277). Separate groups of rats also received an injection of anti-RANKL antibody, osteoprotegerin fusion protein (OPG-Fc), or a control fusion protein (L6-Fc) into gingival papillae in addition to\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">P. gingivalis<\/jats:named-content>\n            infection. Robust serum IgG and salivary IgA antibody (\n            <jats:italic>P<\/jats:italic>\n            &lt; 0.01) and T cell proliferation (\n            <jats:italic>P<\/jats:italic>\n            &lt; 0.05) responses to\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">P. gingivalis<\/jats:named-content>\n            were detected at day 7 and peaked at day 28 in\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">P. gingivalis<\/jats:named-content>\n            -infected rats. Both the concentration of soluble RANKL (sRANKL) in rat gingival tissues (\n            <jats:italic>P<\/jats:italic>\n            &lt; 0.01) and periodontal bone resorption (\n            <jats:italic>P<\/jats:italic>\n            &lt; 0.05) were significantly elevated at day 28 in the\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">P. gingivalis<\/jats:named-content>\n            -infected group compared to levels in the uninfected group. Correspondingly, RANKL-expressing T and B cells in rat gingival tissues were significantly increased at day 28 in the\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">P. gingivalis<\/jats:named-content>\n            -infected group compared to the levels in the uninfected group (\n            <jats:italic>P<\/jats:italic>\n            &lt; 0.01). Injection of anti-RANKL antibody (\n            <jats:italic>P<\/jats:italic>\n            &lt; 0.05) or OPG-Fc (\n            <jats:italic>P<\/jats:italic>\n            &lt; 0.01), but not L6-Fc, into rat gingival papillae after\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">P. gingivalis<\/jats:named-content>\n            infection resulted in significantly reduced periodontal bone resorption. This study suggests that\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">P. gingivalis<\/jats:named-content>\n            infection-associated periodontal bone resorption is RANKL dependent and is accompanied by increased local infiltration of RANKL-expressing T and B cells.\n          <\/jats:p>","DOI":"10.1128\/iai.00043-13","type":"journal-article","created":{"date-parts":[[2013,2,26]],"date-time":"2013-02-26T04:15:24Z","timestamp":1361852124000},"page":"1502-1509","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":62,"title":["Porphyromonas gingivalis Infection-Associated Periodontal Bone Resorption Is Dependent on Receptor Activator of NF-\u03baB Ligand"],"prefix":"10.1128","volume":"81","author":[{"given":"Xiaozhe","family":"Han","sequence":"first","affiliation":[{"name":"Department of Immunology and Infectious Diseases, The Forsyth Institute, Cambridge, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoping","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Immunology and Infectious Diseases, The Forsyth Institute, Cambridge, Massachusetts, USA"},{"name":"Department of Stomatology, Shengjing Hospital of China Medical University, Shenyang, Liaoning Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqian","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Immunology and Infectious Diseases, The Forsyth Institute, Cambridge, Massachusetts, USA"},{"name":"Department of Periodontology, Peking University School of Stomatology and Hospital of Stomatology, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiang","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Immunology and Infectious Diseases, The Forsyth Institute, Cambridge, Massachusetts, USA"},{"name":"Department of Stomatology, Fourth College of Harbin Medical University, Harbin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihisa","family":"Kawai","sequence":"additional","affiliation":[{"name":"Department of Immunology and Infectious Diseases, The Forsyth Institute, Cambridge, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen B.","family":"LaRosa","sequence":"additional","affiliation":[{"name":"Department of Immunology and Infectious Diseases, The Forsyth Institute, Cambridge, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin A.","family":"Taubman","sequence":"additional","affiliation":[{"name":"Department of Immunology and Infectious Diseases, The Forsyth Institute, Cambridge, Massachusetts, 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