{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T23:47:42Z","timestamp":1771372062825,"version":"3.50.1"},"reference-count":41,"publisher":"American Society for Microbiology","issue":"7","license":[{"start":{"date-parts":[[2014,7,1]],"date-time":"2014-07-01T00:00:00Z","timestamp":1404172800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Lower genital tract infection with\n            <jats:named-content content-type=\"genus-species\">Chlamydia trachomatis<\/jats:named-content>\n            and\n            <jats:named-content content-type=\"genus-species\">C. muridarum<\/jats:named-content>\n            can induce long-lasting hydrosalpinx in the upper genital tract of women and female mice, respectively. However, A\/J mice were highly resistant to induction of long-lasting hydrosalpinx by\n            <jats:named-content content-type=\"genus-species\">C. muridarum<\/jats:named-content>\n            . We further compared host inflammatory responses and chlamydial infection courses between the hydrosalpinx-resistant A\/J mice and CBA\/J mice known to be susceptible to hydrosalpinx induction. Both mouse strains developed robust pyosalpinx during the acute phase followed by hydrosalpinx during the chronic phase. However, the hydrosalpinges disappeared in A\/J mice by day 60 after infection, suggesting that some early hydrosalpinges are reversible. Although the overall inflammatory responses were indistinguishable between CBA\/J and A\/J mice, we found significantly more neutrophils in oviduct lumen of A\/J mice on days 7 and 10, which correlated with a rapid but transient oviduct invasion by\n            <jats:named-content content-type=\"genus-species\">C. muridarum<\/jats:named-content>\n            with a peak infection on day 7. In contrast, CBA\/J mice developed a delayed and extensive oviduct infection. These comparisons have revealed an important role of the interactions of oviduct infection with inflammatory responses in chlamydial induction of long-lasting hydrosalpinx, suggesting that a rapid but transient invasion of oviduct by chlamydial organisms can prevent the development of the long-lasting hydrosalpinges.\n          <\/jats:p>","DOI":"10.1128\/iai.00055-14","type":"journal-article","created":{"date-parts":[[2014,4,8]],"date-time":"2014-04-08T06:06:51Z","timestamp":1396937211000},"page":"2688-2696","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":40,"title":["Lack of Long-Lasting Hydrosalpinx in A\/J Mice Correlates with Rapid but Transient Chlamydial Ascension and Neutrophil Recruitment in the Oviduct following Intravaginal Inoculation with Chlamydia muridarum"],"prefix":"10.1128","volume":"82","author":[{"given":"Hongbo","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of 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