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We reviewed the nature of polymicrobial interactions between<jats:named-content content-type=\"genus-species\">S. aureus<\/jats:named-content>and other bacterial, fungal, and viral cocolonizers. Microbes that were frequently recovered from the infection site with<jats:named-content content-type=\"genus-species\">S. aureus<\/jats:named-content>are<jats:named-content content-type=\"genus-species\">Haemophilus influenzae<\/jats:named-content>,<jats:named-content content-type=\"genus-species\">Enterococcus faecalis<\/jats:named-content>,<jats:named-content content-type=\"genus-species\">Pseudomonas aeruginosa<\/jats:named-content>,<jats:named-content content-type=\"genus-species\">Streptococcus pneumoniae<\/jats:named-content>,<jats:named-content content-type=\"genus-species\">Corynebacterium<\/jats:named-content>sp.,<jats:named-content content-type=\"genus-species\">Lactobacillus<\/jats:named-content>sp.,<jats:named-content content-type=\"genus-species\">Candida albicans<\/jats:named-content>, and influenza virus. Detailed analyses of several<jats:italic>in vitro<\/jats:italic>and<jats:italic>in vivo<\/jats:italic>observations demonstrate that<jats:named-content content-type=\"genus-species\">S. aureus<\/jats:named-content>exhibits cooperative relations with<jats:named-content content-type=\"genus-species\">C. albicans<\/jats:named-content>,<jats:named-content content-type=\"genus-species\">E. faecalis<\/jats:named-content>,<jats:named-content content-type=\"genus-species\">H. influenzae<\/jats:named-content>, and influenza virus and competitive relations with<jats:named-content content-type=\"genus-species\">P. aeruginosa<\/jats:named-content>,<jats:named-content content-type=\"genus-species\">Streptococcus pneumoniae<\/jats:named-content>,<jats:named-content content-type=\"genus-species\">Lactobacillus<\/jats:named-content>sp., and<jats:named-content content-type=\"genus-species\">Corynebacterium<\/jats:named-content>sp. Interactions of both types influence changes in<jats:named-content content-type=\"genus-species\">S. aureus<\/jats:named-content>that alter its characteristics in terms of colony formation, protein expression, pathogenicity, and antibiotic susceptibility.<\/jats:p>","DOI":"10.1128\/iai.00059-14","type":"journal-article","created":{"date-parts":[[2014,3,19]],"date-time":"2014-03-19T04:09:28Z","timestamp":1395202168000},"page":"2162-2169","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":139,"title":["Impact of Staphylococcus aureus on Pathogenesis in Polymicrobial Infections"],"prefix":"10.1128","volume":"82","author":[{"given":"Nisha","family":"Nair","sequence":"first","affiliation":[{"name":"Amrita Center for Nanosciences and Molecular Medicine, Amrita Institute of Medical Sciences, AIMS\u2014Edapally, Cochin, Kerala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raja","family":"Biswas","sequence":"additional","affiliation":[{"name":"Amrita Center for Nanosciences and Molecular Medicine, Amrita Institute of Medical Sciences, AIMS\u2014Edapally, Cochin, Kerala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Friedrich","family":"G\u00f6tz","sequence":"additional","affiliation":[{"name":"Microbial Genetics, Interfaculty Institute for Microbiology and Infection Medicine T\u00fcbingen (IMIT), University of T\u00fcbingen, T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lalitha","family":"Biswas","sequence":"additional","affiliation":[{"name":"Amrita Center for Nanosciences and Molecular Medicine, Amrita Institute of Medical Sciences, AIMS\u2014Edapally, Cochin, Kerala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/br.27.1.56-71.1963"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(05)70295-4"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/0-387-30744-3_1"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid1211.060190"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid1203.051040"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.221382"},{"key":"e_1_3_2_8_2","first-page":"53","article-title":"Staphylococcal pore-forming toxins","volume":"257","author":"Pr\u00e9vost G","year":"2001","unstructured":"Pr\u00e9vostG MoureyL ColinDA MenestrinaG. 2001. 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