{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T08:48:05Z","timestamp":1790930885948,"version":"4.1.0"},"reference-count":32,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[2013,6,1]],"date-time":"2013-06-01T00:00:00Z","timestamp":1370044800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Adaptation to oxygen deficiency is essential for virulence and persistence of\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Brucella<\/jats:named-content>\n            inside the host. The flexibility of this bacterium with respect to oxygen depletion is remarkable, since\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Brucella suis<\/jats:named-content>\n            can use an oxygen-dependent transcriptional regulator of the FnrN family, two high-oxygen-affinity terminal oxidases, and a complete denitrification pathway to resist various conditions of oxygen deficiency. Moreover, our previous results suggested that oxidative respiration and denitrification can be simultaneously used by\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">B. suis<\/jats:named-content>\n            under microaerobiosis. The requirement of a functional cytochrome\n            <jats:italic>bd<\/jats:italic>\n            ubiquinol oxidase for nitrite reductase expression evidenced the linkage of these two pathways, and the central role of the two-component system RegB\/RegA in the coordinated control of both respiratory systems was demonstrated. We propose a scheme for global regulation of\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">B. suis<\/jats:named-content>\n            respiratory pathways by the transcriptional regulator RegA, which postulates a role for the cytochrome\n            <jats:italic>bd<\/jats:italic>\n            ubiquinol oxidase in redox signal transmission to the histidine sensor kinase RegB. More importantly, RegA was found to be essential for\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">B. suis<\/jats:named-content>\n            persistence\n            <jats:italic>in vivo<\/jats:italic>\n            within oxygen-limited target organs. It is conceivable that RegA acts as a controller of numerous systems involved in the establishment of the persistent state, characteristic of chronic infections by\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Brucella<\/jats:named-content>\n            .\n          <\/jats:p>","DOI":"10.1128\/iai.00063-13","type":"journal-article","created":{"date-parts":[[2013,3,26]],"date-time":"2013-03-26T00:18:28Z","timestamp":1364257108000},"page":"2053-2061","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":24,"title":["RegA, the Regulator of the Two-Component System RegB\/RegA of Brucella suis, Is a Controller of Both Oxidative Respiration and Denitrification Required for Chronic Infection in Mice"],"prefix":"10.1128","volume":"81","author":[{"given":"Elias","family":"Abdou","sequence":"first","affiliation":[{"name":"Universit\u00e9 Montpellier I, Centre d'\u00e9tudes d'agents Pathog\u00e8nes et Biotechnologies pour la Sant\u00e9 (CPBS), Montpellier, France"},{"name":"CNRS, UMR 5236, CPBS, Montpellier, France"},{"name":"Universit\u00e9 Montpellier II, CPBS, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Am\u00e9lie","family":"Deredjian","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Montpellier I, Centre d'\u00e9tudes d'agents Pathog\u00e8nes et Biotechnologies pour la Sant\u00e9 (CPBS), Montpellier, France"},{"name":"CNRS, UMR 5236, CPBS, Montpellier, France"},{"name":"Universit\u00e9 Montpellier II, CPBS, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Pilar","family":"Jim\u00e9nez de Bag\u00fc\u00e9s","sequence":"additional","affiliation":[{"name":"Unidad de Sanidad Animal, Centro de Investigaci\u00f3n y Tecnolog\u00eda Agroalimentaria, Gobierno de Arag\u00f3n, Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"K\u00f6hler","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Montpellier I, Centre d'\u00e9tudes d'agents Pathog\u00e8nes et Biotechnologies pour la Sant\u00e9 (CPBS), Montpellier, France"},{"name":"CNRS, UMR 5236, CPBS, Montpellier, France"},{"name":"Universit\u00e9 Montpellier II, CPBS, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00e9ronique","family":"Jubier-Maurin","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Montpellier I, Centre d'\u00e9tudes d'agents Pathog\u00e8nes et Biotechnologies pour la Sant\u00e9 (CPBS), Montpellier, France"},{"name":"CNRS, UMR 5236, CPBS, Montpellier, France"},{"name":"Universit\u00e9 Montpellier II, CPBS, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(06)70382-6"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1017\/S095026881000097X"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.0040021"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1462-5822.2001.00102.x"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1041630204"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.232454299"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1086\/319608"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0732-8893(01)00344-3"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid0904.020576"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01185-06"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.73.11.7768-7771.2005"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.200800266"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.74.3.1973-1976.2006"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1232298100"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.68.2.263-279.2004"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/cdg461"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M509687200"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00272-10"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00443-07"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/19.16.4237"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.184.13.3521-3529.2002"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00301-08"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-78885-2_9"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2005.03.037"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.186.18.6025-6031.2004"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.188.4.1615-1619.2006"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.28167-0"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.184.10.2815-2820.2002"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2012.08096.x"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2012.08095.x"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1021\/pr800978p"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.micro.55.1.139"}],"container-title":["Infection and Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/IAI.00063-13","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/IAI.00063-13","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,4]],"date-time":"2022-03-04T20:14:57Z","timestamp":1646424897000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/IAI.00063-13"}},"subtitle":[],"editor":[{"given":"A.","family":"Camilli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,6]]},"references-count":32,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013,6]]}},"alternative-id":["10.1128\/IAI.00063-13"],"URL":"https:\/\/doi.org\/10.1128\/iai.00063-13","relation":{},"ISSN":["0019-9567","1098-5522"],"issn-type":[{"value":"0019-9567","type":"print"},{"value":"1098-5522","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,6]]},"assertion":[{"value":"2013-01-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-03-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-05-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}