{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:31:02Z","timestamp":1787016662627,"version":"build-2736575974"},"reference-count":42,"publisher":"American Society for Microbiology","issue":"9","license":[{"start":{"date-parts":[[2006,9,1]],"date-time":"2006-09-01T00:00:00Z","timestamp":1157068800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2006,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Salmonella enterica<\/jats:italic>\n                    subspecies 1 serovar Typhimurium is an enteric bacterial pathogen infecting a broad range of hosts. In susceptible\n                    <jats:italic>Nramp1<\/jats:italic>\n                    <jats:sup>\u2212<\/jats:sup>\n                    <jats:sup>\/<\/jats:sup>\n                    <jats:sup>\u2212<\/jats:sup>\n                    (\n                    <jats:italic>Slc11\u03b11<\/jats:italic>\n                    <jats:sup>\u2212<\/jats:sup>\n                    <jats:sup>\/<\/jats:sup>\n                    <jats:sup>\u2212<\/jats:sup>\n                    ) mice, serovar Typhimurium cannot efficiently colonize the intestine but causes a systemic typhoid-like infection. However, after pretreatment with streptomycin, these susceptible (C57BL\/6 and BALB\/c) mice develop acute serovar Typhimurium-induced colitis (M. Barthel et al., Infect. Immun.\n                    <jats:bold>71:<\/jats:bold>\n                    2839-2858, 2003). It was not clear whether resistant\n                    <jats:italic>Nramp1<\/jats:italic>\n                    <jats:sup>+\/+<\/jats:sup>\n                    (\n                    <jats:italic>Slc11\u03b11<\/jats:italic>\n                    <jats:sup>+\/+<\/jats:sup>\n                    ) mouse strains would similarly develop colitis. Here we compared serovar Typhimurium infection in streptomycin-pretreated susceptible (C57BL\/6) and resistant (DBA\/2 and 129Sv\/Ev) mouse strains: We found that acute colitis (days 1 and 3 postinfection) is strikingly similar in susceptible and resistant mice. In 129Sv\/Ev mice we followed the serovar Typhimurium infection for as long as 6 weeks. After the initial phase of acute colitis, these animals developed chronic crypt-destructive colitis, including ulceration, crypt abscesses, pronounced mucosal and submucosal infiltrates, overshooting regeneration of the epithelium, and crypt branching. Moreover, we observed inflammation of the gall duct epithelium (cholangitis) in the 129Sv\/Ev mice between days 14 and 43 of infection. Cholangitis was not attributable to side effects of the streptomycin treatment. Furthermore, chronic infection of 129Sv\/Ev mice in a typhoid fever model did not lead to cholangitis. We propose that streptomycin-pretreated 129Sv\/Ev mice provide a robust murine model for chronic enteric salmonellosis including complications such as cholangitis.\n                  <\/jats:p>","DOI":"10.1128\/iai.00072-06","type":"journal-article","created":{"date-parts":[[2006,8,22]],"date-time":"2006-08-22T18:13:07Z","timestamp":1156270387000},"page":"5047-5057","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":74,"title":["Chronic\n                    <i>Salmonella enterica<\/i>\n                    Serovar Typhimurium-Induced Colitis and Cholangitis in Streptomycin-Pretreated\n                    <i>Nramp1<\/i>\n                    <sup>+\/+<\/sup>\n                    Mice"],"prefix":"10.1128","volume":"74","author":[{"given":"Ba\u0308rbel","family":"Stecher","sequence":"first","affiliation":[{"name":"Institute of Microbiology, D-BIOL, ETH Zu\u0308rich, Wolfgang-Pauli Strasse 10, 8093 Zu\u0308rich"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gu\u0308nther","family":"Paesold","sequence":"additional","affiliation":[{"name":"Institute of Microbiology, D-BIOL, ETH Zu\u0308rich, Wolfgang-Pauli Strasse 10, 8093 Zu\u0308rich"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manja","family":"Barthel","sequence":"additional","affiliation":[{"name":"Institute of Microbiology, D-BIOL, ETH Zu\u0308rich, Wolfgang-Pauli Strasse 10, 8093 Zu\u0308rich"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus","family":"Kremer","sequence":"additional","affiliation":[{"name":"Institute of Pathology, Technische Universita\u0308t Mu\u0308nchen, Ismaninger Strasse 22, D-81675 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Jantsch","sequence":"additional","affiliation":[{"name":"Institute of Clinical Pathology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Stallmach","sequence":"additional","affiliation":[{"name":"Institute of Clinical Pathology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathias","family":"Heikenwalder","sequence":"additional","affiliation":[{"name":"Institute of Neuropathology, Universita\u0308tsspital Zu\u0308rich, Schmelzbergstrasse 12, 8091 Zu\u0308rich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolf-Dietrich","family":"Hardt","sequence":"additional","affiliation":[{"name":"Institute of Microbiology, D-BIOL, ETH Zu\u0308rich, Wolfgang-Pauli Strasse 10, 8093 Zu\u0308rich"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.71.5.2839-2858.2003"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1286-4579(99)80010-0"},{"key":"e_1_3_2_4_2","doi-asserted-by":"crossref","first-page":"3143","DOI":"10.4049\/jimmunol.144.8.3143","volume":"144","year":"1990","unstructured":"Benjamin, W. 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