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While numerous studies have identified important contributions of adaptive immune responses to parasite control, much less work has examined innate immunity and its connections to the adaptive response during this infection. We explored the role of complement in immunity to<jats:named-content content-type=\"genus-species\">Giardia<\/jats:named-content>using mice deficient in mannose-binding lectin (Mbl2) or complement factor 3a receptor (C3aR). Both strains exhibited delayed clearance of parasites and a reduced ability to recruit mast cells in the intestinal submucosa. C3aR-deficient mice had normal production of antiparasite IgA, but<jats:italic>ex vivo<\/jats:italic>T cell recall responses were impaired. These data suggest that complement is a key factor in the innate recognition of<jats:named-content content-type=\"genus-species\">Giardia<\/jats:named-content>and that recruitment of mast cells and activation of T cell immunity through C3a are important for parasite control.<\/jats:p>","DOI":"10.1128\/iai.00074-16","type":"journal-article","created":{"date-parts":[[2016,2,2]],"date-time":"2016-02-02T04:18:57Z","timestamp":1454386737000},"page":"1092-1099","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":28,"title":["Complement Activation by Giardia duodenalis Parasites through the Lectin Pathway Contributes to Mast Cell Responses and Parasite Control"],"prefix":"10.1128","volume":"84","author":[{"given":"Erqiu","family":"Li","sequence":"first","affiliation":[{"name":"Department of Biology, Georgetown University, Washington, DC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernest A.","family":"Tako","sequence":"additional","affiliation":[{"name":"Department of Biology, Georgetown University, Washington, DC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5719-7535","authenticated-orcid":false,"given":"Steven M.","family":"Singer","sequence":"additional","affiliation":[{"name":"Department of Biology, Georgetown University, Washington, DC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-199701000-00018"},{"key":"e_1_3_2_3_2","first-page":"1","article-title":"Giardia\u2014diagnosis, clinical course and epidemiology. 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