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Generally, the\n            <jats:named-content content-type=\"genus-species\">V. cholerae<\/jats:named-content>\n            O1 classical biotype is polymyxin B (PB) sensitive and El Tor is relatively resistant. Detection of classical biotype traits like the production of classical cholera toxin and PB sensitivity in El Tor strains has been reported in recent years, including in the devastating Yemen cholera outbreak during 2016-2018. To investigate the factor(s) responsible for the shift in the trend of sensitivity to PB, we studied the two-component system encoded by\n            <jats:italic>carRS<\/jats:italic>\n            , regulating the lipid A modification of El Tor vibrios, and found that only\n            <jats:italic>carR<\/jats:italic>\n            contains a single nucleotide polymorphism (SNP) in recently emerged PB-sensitive strains.\n          <\/jats:p>","DOI":"10.1128\/iai.00080-20","type":"journal-article","created":{"date-parts":[[2020,2,24]],"date-time":"2020-02-24T12:04:22Z","timestamp":1582545862000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":24,"title":["A Point Mutation in\n            <i>carR<\/i>\n            Is Involved in the Emergence of Polymyxin B-Sensitive Vibrio cholerae O1 El Tor Biotype by Influencing Gene Transcription"],"prefix":"10.1128","volume":"88","author":[{"given":"Prosenjit","family":"Samanta","sequence":"first","affiliation":[{"name":"Division of Bacteriology, ICMR-National Institute of Cholera and Enteric Diseases, Kolkata, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahul Shubhra","family":"Mandal","sequence":"additional","affiliation":[{"name":"Biomedical Informatics Center, ICMR-National Institute of Cholera and Enteric Diseases, Kolkata, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudra Narayan","family":"Saha","sequence":"additional","affiliation":[{"name":"Division of Bacteriology, ICMR-National Institute of Cholera and Enteric Diseases, Kolkata, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sreeja","family":"Shaw","sequence":"additional","affiliation":[{"name":"Division of Bacteriology, ICMR-National Institute of Cholera and Enteric Diseases, Kolkata, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priyanka","family":"Ghosh","sequence":"additional","affiliation":[{"name":"Division of Bacteriology, ICMR-National Institute of Cholera and Enteric Diseases, Kolkata, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanta","family":"Dutta","sequence":"additional","affiliation":[{"name":"Division of Bacteriology, ICMR-National Institute of Cholera and Enteric Diseases, Kolkata, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit","family":"Ghosh","sequence":"additional","affiliation":[{"name":"Division of Bacteriology, ICMR-National Institute of Cholera and Enteric Diseases, Kolkata, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Imamura","sequence":"additional","affiliation":[{"name":"Okayama University, Okayama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masatomo","family":"Morita","sequence":"additional","affiliation":[{"name":"Department of Bacteriology I, National Institute of Infectious Diseases, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Ohnishi","sequence":"additional","affiliation":[{"name":"Department of Bacteriology I, National Institute of Infectious Diseases, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thandavarayan","family":"Ramamurthy","sequence":"additional","affiliation":[{"name":"Center for Human Microbial Ecology, Translational Health Science and Technology Institute, Faridabad, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asish Kumar","family":"Mukhopadhyay","sequence":"additional","affiliation":[{"name":"Division of Bacteriology, ICMR-National Institute of Cholera and Enteric Diseases, Kolkata, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.8.1.48"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1012928"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(18)30230-4"},{"key":"e_1_3_3_5_2","first-page":"11","volume-title":"Cholera","author":"Pollitzer R","year":"1959","unstructured":"Pollitzer R. 1959. 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