{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:30:49Z","timestamp":1787016649630,"version":"build-2736575974"},"reference-count":51,"publisher":"American Society for Microbiology","issue":"10","license":[{"start":{"date-parts":[[2006,10,1]],"date-time":"2006-10-01T00:00:00Z","timestamp":1159660800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2006,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The progression of murine mycoplasma pneumonia is dependent on T cells and other immune cells. The role of cytokines in immunity are complex, and identifying the network of cytokines produced after infection of mice is essential in dissecting the key cytokine cascades involved mycoplasma disease pathogenesis. In the present study, mRNA expression of 143 different cytokines, chemokines, or receptors were evaluated in lung tissues from both susceptible (BALB\/c and C3H\/HeN) and resistant (C57BL\/6) mice after\n                    <jats:italic>Mycoplasma pulmonis<\/jats:italic>\n                    infection. To accomplish this, membrane-based cDNA microarrays were used to monitor changes mRNA expression in lungs. There was a clear association with disease susceptibility and development of cytokine mRNA expression. In addition to proinflammatory cytokines, mRNA expression of an anti-inflammatory cytokine, interleukin-10, increased with disease severity, suggesting an attempt to moderate the severity of the inflammatory response. Furthermore, it is clear that an array of chemokines produced in susceptible mice could contribute to the recruitment and maintenance of inflammatory cells at the site of disease. In support of this, there was an increase in macrophage inflammatory protein 1\u03b2 (MIP-1\u03b2; CCL4) and monocyte chemoattractant protein 2 (MCP-2; CCL8) mRNA levels from mycoplasma-infected mice and a corresponding accumulation of CD4\n                    <jats:sup>+<\/jats:sup>\n                    Th cells expressing the MIP-1\u03b2\/MCP-2 receptor, CCR5, in the lungs of mice. Furthermore, MIP-1\u03b2- and MCP-2-producing cells and CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells were found to be in close association in pulmonary lesions. Thus, there was a significant cytokine response associated with disease pathogenesis, and these studies provide important leads and insights into ongoing cytokine- and chemokine-mediated processes in this persistent inflammatory disease.\n                  <\/jats:p>","DOI":"10.1128\/iai.00082-06","type":"journal-article","created":{"date-parts":[[2006,9,20]],"date-time":"2006-09-20T19:06:35Z","timestamp":1158779195000},"page":"5943-5954","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":36,"title":["Cytokine and Chemokine Transcription Profile during\n                    <i>Mycoplasma pulmonis<\/i>\n                    Infection in Susceptible and Resistant Strains of Mice: Macrophage Inflammatory Protein 1\u03b2 (CCL4) and Monocyte Chemoattractant Protein 2 (CCL8) and Accumulation of CCR5\n                    <sup>+<\/sup>\n                    Th Cells"],"prefix":"10.1128","volume":"74","author":[{"given":"Xiangle","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, Texas 76107"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harlan P.","family":"Jones","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, Texas 76107"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa M.","family":"Hodge","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, Texas 76107"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerry W.","family":"Simecka","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, Texas 76107"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/jlb.52.3.303"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1517\/14712598.3.6.875"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.194.10.1497"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.66.8.3485-3491.1998"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.64.12.5326-5331.1996"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.63.10.4138-4142.1995"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1973.tb45665.x"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.121.6.1071"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.50.3.647-654.1985"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.49.1.152-158.1985"},{"key":"e_1_3_2_12_2","first-page":"388","volume":"98","year":"1994","unstructured":"Evengard, B., K. Sandstedt, G. Bolske, R. Feinstein, I. Riesenfelt-Orn, and C. I. Smith. 1994. Intranasal inoculation of Mycoplasma pulmonis in mice with severe combined immunodeficiency (SCID) causes a wasting disease with grave arthritis. Clin. Exp. Immunol.98:388-394.","journal-title":"Clin. Exp. Immunol."},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.63.10.4084-4090.1995"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/17.Supplement_1.S37"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/139.6.681"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1386-6532(99)00030-X"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.65.6.2278-2282.1997"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2567.2000.00053.x"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.168.7.3493"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.166.2.1141"},{"key":"e_1_3_2_21_2","doi-asserted-by":"crossref","first-page":"3859","DOI":"10.4049\/jimmunol.162.7.3859","volume":"162","year":"1999","unstructured":"Kellermann, S. A., S. Hudak, E. R. Oldham, Y. J. Liu, and L. M. McEvoy. 1999. The CC chemokine receptor-7 ligands 6Ckine and macrophage inflammatory protein-3\u03b2 are potent chemoattractants for in vitro- and in vivo-derived dendritic cells. J. Immunol.162:3859-3864.","journal-title":"J. Immunol."},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.27.1.192-196.1980"},{"key":"e_1_3_2_23_2","doi-asserted-by":"crossref","first-page":"4878","DOI":"10.4049\/jimmunol.163.9.4878","volume":"163","year":"1999","unstructured":"Koga, S., M. B. Auerbach, T. M. Engeman, A. C. Novick, H. Toma, and R. L. Fairchild. 1999. T-cell infiltration into class II MHC-disparate allografts and acute rejection is dependent on the IFN-gamma-induced chemokine Mig. J. Immunol.163:4878-4885.","journal-title":"J. Immunol."},{"key":"e_1_3_2_24_2","unstructured":"Krause D. C. and D. Taylor-Robinson (ed.). 1993. Mycoplasma which infect humans. American Society for Microbiology Washington D.C."},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.187.4.655"},{"key":"e_1_3_2_26_2","doi-asserted-by":"crossref","first-page":"186","DOI":"10.4049\/jimmunol.162.1.186","volume":"162","year":"1999","unstructured":"Liao, F., R. L. Rabin, C. S. Smith, G. Sharma, T. B. Nutman, and J. M. Farber. 1999. CC-chemokine receptor 6 is expressed on diverse memory subsets of T cells and determines responsiveness to macrophage inflammatory protein 3 alpha. J. Immunol.162:186-194.","journal-title":"J. Immunol."},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2001.113563"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1159\/000015538"},{"key":"e_1_3_2_29_2","first-page":"186","year":"1971","unstructured":"Mizutani, H., T. Kitayama, A. Hayakawa, and E. Nagayama. 1971. Delayed hypersensitivity in Mycoplasma pneumoniae infections. Lanceti:186-187.","journal-title":"Lancet"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.70.11.6284-6293.2002"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1086\/376510"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/4.Supplement_1.S205"},{"key":"e_1_3_2_33_2","first-page":"95","volume":"135","year":"1984","unstructured":"Naot, Y., S. Davidson, and E. S. Lindenbaum. 1984. Role of mitogenicity in pathogenicity of mycoplasmas for murine hosts. Ann. Microbiol.135A:95-101.","journal-title":"Ann. Microbiol."},{"key":"e_1_3_2_34_2","first-page":"399","volume":"36","year":"1979","unstructured":"Naot, Y., S. Merchav, E. Ben-David, and H. Ginsburg. 1979. Mitogenic activity of Mycoplasma pulmonis. I. Stimulation of rat B and T lymphocytes. Immunology36:399-406.","journal-title":"Immunology"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.iy.09.040191.003153"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.7.3705"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.55.11.2631-2635.1987"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0966-842X(00)01919-3"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0952-7915(00)00226-0"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.185.1.99"},{"key":"e_1_3_2_41_2","first-page":"203","year":"2003","unstructured":"Simecka, J. W. 2003. Contrasting roles of immunity in mycoplasma respiratory disease, p. 203-219. In S. G. Pandalai (ed.), Recent research developments in infection and immunity. Transworld Research Network.","journal-title":"Transworld Research Network"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002849900439"},{"key":"e_1_3_2_43_2","first-page":"391","year":"1992","unstructured":"Simecka, J. W., J. K. Davis, M. K. Davidson, S. E. Ross, C. Stadtlander, and G. H. Cassell. 1992. Mycoplasma diseases of animals, p. 391-415. In J. Maniloff, R. N. McElhaney, L. R. Finch, and J. B. Baseman (ed.), Mycoplasmas: molecular biology and pathogenesis. American Society for Microbiology, Washington, D.C.","journal-title":"Mycoplasmas: molecular biology and pathogenesis"},{"key":"e_1_3_2_44_2","doi-asserted-by":"crossref","first-page":"550","DOI":"10.4049\/jimmunol.160.2.550","volume":"160","year":"1998","unstructured":"Siveke, J. T., and A. Hamann. 1998. T helper 1 and T helper 2 cells respond differentially to chemokines. J. Immunol.160:550-554.","journal-title":"J. Immunol."},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117788"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1099\/00222615-7-3-343"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.194.10.f53"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-1033.2003.03760.x"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2004.06.019"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.11.6875"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.73.10.6742-6751.2005"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.69.5.2865-2871.2001"}],"container-title":["Infection and Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/IAI.00082-06","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/IAI.00082-06","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,8]],"date-time":"2023-05-08T18:50:38Z","timestamp":1683571838000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/IAI.00082-06"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,10]]},"references-count":51,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2006,10]]}},"alternative-id":["10.1128\/IAI.00082-06"],"URL":"https:\/\/doi.org\/10.1128\/iai.00082-06","relation":{},"ISSN":["0019-9567","1098-5522"],"issn-type":[{"value":"0019-9567","type":"print"},{"value":"1098-5522","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,10]]},"assertion":[{"value":"2006-01-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2006-07-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2006-10-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}