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To date, however, only a few virulence factors have been described for\n                    <jats:named-content content-type=\"genus-species\">Leishmania major<\/jats:named-content>\n                    , one of the causative agents of cutaneous leishmaniasis. Here, we have characterized the expression and function of an\n                    <jats:named-content content-type=\"genus-species\">L. major<\/jats:named-content>\n                    phosphatase, which we termed LmPRL-1. This enzyme shows a strong structural similarity to the human phosphatases of regenerating liver (PRL-1, -2, and -3) that regulate the proliferation, differentiation, and motility of cells. The biochemical characterization of the\n                    <jats:named-content content-type=\"genus-species\">L. major<\/jats:named-content>\n                    phosphatase revealed that the enzyme is redox sensitive. When analyzing the subcellular localization of LmPRL-1 in promastigotes, amastigotes, and infected macrophages, we found that the phosphatase was predominantly expressed and secreted by promastigotes via the exosome route. Finally, we observed that ectopic expression of LmPRL-1 in\n                    <jats:named-content content-type=\"genus-species\">L. major<\/jats:named-content>\n                    led to an increased number of parasites in macrophages. From these data, we conclude that the\n                    <jats:named-content content-type=\"genus-species\">L. major<\/jats:named-content>\n                    phosphatase LmPRL-1 contributes to the intracellular survival of the parasites in macrophages.\n                  <\/jats:p>","DOI":"10.1128\/iai.00084-17","type":"journal-article","created":{"date-parts":[[2017,5,15]],"date-time":"2017-05-15T20:50:17Z","timestamp":1494881417000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":37,"title":["Characterization of the Protein Tyrosine Phosphatase LmPRL-1 Secreted by Leishmania major via the Exosome Pathway"],"prefix":"10.1128","volume":"85","author":[{"given":"Sabine","family":"Leitherer","sequence":"first","affiliation":[{"name":"Mikrobiologisches Institut-Klinische Mikrobiologie, Immunologie und Hygiene, Universit\u00e4tsklinikum Erlangen, Friedrich-Alexander-Universit\u00e4t (FAU) Erlangen-N\u00fcrnberg, 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