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Here we describe the identification and functional characterization of a surface lipoprotein of<jats:italic>B. parkeri<\/jats:italic>, designated BpcA, that binds the human complement regulators factor H and factor H-related protein 1 and, simultaneously, the host protease plasminogen. In contrast, the homologous<jats:italic>B. turicatae<\/jats:italic>protein failed to bind human factor H and factor H-related protein 1 but retained its plasminogen binding capacity. Factor H bound to BpcA maintains its regulatory capacity to control C3b deposition and C3 convertase activity. Ectopic expression of BpcA in a serum-sensitive<jats:italic>B. burgdorferi<\/jats:italic>strain protects transformed cells from complement-mediated killing. Furthermore, bound plasminogen\/plasmin endows<jats:italic>B. parkeri<\/jats:italic>and<jats:italic>B. turicatae<\/jats:italic>with the potential to degrade extracellular matrix components. These findings expand our understanding of the putative recent evolutionary separation of<jats:italic>Borrelia parkeri<\/jats:italic>and<jats:italic>Borrelia turicatae<\/jats:italic>, provide evidence that<jats:italic>B. parkeri<\/jats:italic>differs from<jats:italic>B. turicatae<\/jats:italic>in its ability to resist complement attack, and may help in understanding the pathological processes underlying tick-borne relapsing fever.<\/jats:p>","DOI":"10.1128\/iai.00089-10","type":"journal-article","created":{"date-parts":[[2010,3,16]],"date-time":"2010-03-16T03:54:57Z","timestamp":1268711697000},"page":"2199-2208","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":32,"title":["Molecular Characterization of the Interaction of<i>Borrelia parkeri<\/i>and<i>Borrelia turicatae<\/i>with Human Complement Regulators"],"prefix":"10.1128","volume":"78","author":[{"given":"Melanie","family":"Schott","sequence":"first","affiliation":[{"name":"Infectious Immunology Group, Institute for Immunology, University of Heidelberg, Heidelberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonja","family":"Grosskinsky","sequence":"additional","affiliation":[{"name":"Infectious Immunology Group, Institute for Immunology, University of Heidelberg, Heidelberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christiane","family":"Brenner","sequence":"additional","affiliation":[{"name":"Infectious Immunology Group, Institute for Immunology, University of Heidelberg, Heidelberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Kraiczy","sequence":"additional","affiliation":[{"name":"Institute of Medical Microbiology and Infection Control, University Hospital of Frankfurt, Frankfurt, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reinhard","family":"Wallich","sequence":"additional","affiliation":[{"name":"Infectious Immunology Group, Institute for Immunology, University of Heidelberg, Heidelberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.5.3299"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.67.6.2874-2883.1999"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.2000.01698.x"},{"key":"e_1_3_2_5_2","first-page":"13","volume":"97","year":"1994","unstructured":"Ciceroni, L., A. 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