{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T14:53:12Z","timestamp":1781880792655,"version":"3.54.5"},"reference-count":60,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[2015,5,1]],"date-time":"2015-05-01T00:00:00Z","timestamp":1430438400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:named-content content-type=\"genus-species\">Yersinia pestis<\/jats:named-content>is the causative agent of plague. This bacterium evolved from an ancestral enteroinvasive<jats:named-content content-type=\"genus-species\">Yersinia pseudotuberculosis<\/jats:named-content>strain by gene loss and acquisition of new genes, allowing it to use fleas as transmission vectors. Infection frequently leads to a rapidly lethal outcome in humans, a variety of rodents, and cats. This study focuses on the<jats:named-content content-type=\"genus-species\">Y. pestis<\/jats:named-content>KIM<jats:italic>yapV<\/jats:italic>gene and its product, recognized as an autotransporter protein by its typical sequence, outer membrane localization, and amino-terminal surface exposure. Comparison of<jats:named-content content-type=\"genus-species\">Yersinia<\/jats:named-content>genomes revealed that DNA encoding YapV or each of three individual paralogous proteins (YapK, YapJ, and YapX) was present as a gene or pseudogene in a strain-specific manner and only in<jats:named-content content-type=\"genus-species\">Y. pestis<\/jats:named-content>and<jats:named-content content-type=\"genus-species\">Y. pseudotuberculosis<\/jats:named-content>. YapV acted as an adhesin for alveolar epithelial cells and specific extracellular matrix (ECM) proteins, as shown with recombinant<jats:named-content content-type=\"genus-species\">Escherichia coli<\/jats:named-content>,<jats:named-content content-type=\"genus-species\">Y. pestis<\/jats:named-content>, or purified passenger domains. Like YapV, YapK and YapJ demonstrated adhesive properties, suggesting that their previously related<jats:italic>in vivo<\/jats:italic>activity is due to their capacity to modulate binding properties of<jats:named-content content-type=\"genus-species\">Y. pestis<\/jats:named-content>in its hosts, in conjunction with other adhesins. A differential host-specific type of binding to ECM proteins by YapV, YapK, and YapJ suggested that these proteins participate in broadening the host range of<jats:named-content content-type=\"genus-species\">Y. pestis<\/jats:named-content>. A phylogenic tree including 36<jats:named-content content-type=\"genus-species\">Y. pestis<\/jats:named-content>strains highlighted an association between the gene profile for the four paralogous proteins and the geographic location of the corresponding isolated strains, suggesting an evolutionary adaption of<jats:named-content content-type=\"genus-species\">Y. pestis<\/jats:named-content>to specific local animal hosts or reservoirs.<\/jats:p>","DOI":"10.1128\/iai.00094-15","type":"journal-article","created":{"date-parts":[[2015,2,18]],"date-time":"2015-02-18T08:16:15Z","timestamp":1424247375000},"page":"1809-1819","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":18,"title":["Adhesive Properties of YapV and Paralogous Autotransporter Proteins of Yersinia pestis"],"prefix":"10.1128","volume":"83","author":[{"given":"Manoj K. 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