{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T04:50:38Z","timestamp":1781585438876,"version":"3.54.5"},"reference-count":80,"publisher":"American Society for Microbiology","issue":"8","license":[{"start":{"date-parts":[[2020,7,21]],"date-time":"2020-07-21T00:00:00Z","timestamp":1595289600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["1R01AI109096"],"award-info":[{"award-number":["1R01AI109096"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["R35GM122461"],"award-info":[{"award-number":["R35GM122461"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["AI139369-01A1"],"award-info":[{"award-number":["AI139369-01A1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["1R01AI146048"],"award-info":[{"award-number":["1R01AI146048"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2020,7,21]]},"abstract":"<jats:p>Colonization by pathogenic bacteria depends on their ability to overcome host nutritional defenses and acquire nutrients. The human pathogen group A streptococcus (GAS) encounters the host defense factor calprotectin (CP) during infection. CP inhibits GAS growth<jats:italic>in vitro<\/jats:italic>by imposing zinc (Zn) limitation. However, GAS counterstrategies to combat CP-mediated Zn limitation and the<jats:italic>in vivo<\/jats:italic>relevance of CP-GAS interactions to bacterial pathogenesis remain unknown. Here, we report that GAS upregulates the AdcR regulon in response to CP-mediated Zn limitation.<\/jats:p>","DOI":"10.1128\/iai.00097-20","type":"journal-article","created":{"date-parts":[[2020,5,11]],"date-time":"2020-05-11T13:56:31Z","timestamp":1589205391000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":27,"title":["Group A Streptococcus AdcR Regulon Participates in Bacterial Defense against Host-Mediated Zinc Sequestration and Contributes to Virulence"],"prefix":"10.1128","volume":"88","author":[{"given":"Nishanth","family":"Makthal","sequence":"first","affiliation":[{"name":"Center for Molecular and Translational Human Infectious Diseases Research, Houston Methodist Research Institute, Houston, Texas, USA"},{"name":"Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hackwon","family":"Do","sequence":"additional","affiliation":[{"name":"Center for Molecular and Translational Human Infectious Diseases Research, Houston Methodist Research Institute, Houston, Texas, USA"},{"name":"Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4273-9797","authenticated-orcid":false,"given":"Brian M.","family":"Wendel","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Cornell University, Ithaca, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randall J.","family":"Olsen","sequence":"additional","affiliation":[{"name":"Center for Molecular and Translational Human Infectious Diseases Research, Houston Methodist Research Institute, Houston, Texas, USA"},{"name":"Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, Texas, USA"},{"name":"Department of Pathology and Laboratory Medicine, Weill Medical College of Cornell University, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3832-3249","authenticated-orcid":false,"given":"John D.","family":"Helmann","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Cornell University, Ithaca, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James M.","family":"Musser","sequence":"additional","affiliation":[{"name":"Center for Molecular and Translational Human Infectious Diseases Research, Houston Methodist Research Institute, Houston, Texas, USA"},{"name":"Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, Texas, USA"},{"name":"Department of Pathology and Laboratory Medicine, Weill Medical College of Cornell University, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9959-5598","authenticated-orcid":false,"given":"Muthiah","family":"Kumaraswami","sequence":"additional","affiliation":[{"name":"Center for Molecular and Translational Human Infectious Diseases Research, Houston Methodist Research Institute, Houston, Texas, USA"},{"name":"Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1021\/pr0603699"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1021\/ar900015x"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature08300"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja407147d"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1152449"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1220341110"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.6b06845"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.1995.tb03695.x"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2017.05.030"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-6445(03)00041-X"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2005.02.001"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1039\/c4mt00333k"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000949"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1039\/c1mt00073j"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2008.01225.x"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.13.3.470"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(05)70267-X"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1039\/c7mt00240h"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00779-17"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.13-247460"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2016.05.005"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004450"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00544-15"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2012.01.017"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000639"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2006.05.017"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja307974e"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja3096416"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2009.11.008"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gku1304"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2010.08.030"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01299-08"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0152835"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00485-09"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2008.01.003"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jprot.2014.06.026"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.71.12.7043-7052.2003"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkz524"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.1891"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA118.006819"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.9b00250"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00091-17"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00140-17"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.13368"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2014.01.005"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.69.6.3692-3696.2001"},{"key":"e_1_3_3_48_2","doi-asserted-by":"crossref","first-page":"245","DOI":"10.33549\/physiolres.930448","article-title":"Calprotectin\u2014a pleiotropic molecule in acute and chronic inflammation","volume":"53","author":"St\u0159\u00ed\u017e I","year":"2004","unstructured":"St\u0159\u00ed\u017e I, Trebichavsk\u00fd I. 2004. Calprotectin\u2014a pleiotropic molecule in acute and chronic inflammation. Physiol Res 53:245\u2013253.","journal-title":"Physiol Res"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.02155-14"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2014-205668"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2009.12.037"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2011.07862.x"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2006.05577.x"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0146785"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006584"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00837-12"},{"key":"e_1_3_3_57_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00614-16"},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00048-18"},{"key":"e_1_3_3_59_2","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.12504"},{"key":"e_1_3_3_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2007.02.015"},{"key":"e_1_3_3_61_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI124994"},{"key":"e_1_3_3_62_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00802-09"},{"key":"e_1_3_3_63_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2003.03972.x"},{"key":"e_1_3_3_64_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2006.05513.x"},{"key":"e_1_3_3_65_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0081168"},{"key":"e_1_3_3_66_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00757-18"},{"key":"e_1_3_3_67_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2012.06.004"},{"key":"e_1_3_3_68_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-017-1061-8"},{"key":"e_1_3_3_69_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18102197"},{"key":"e_1_3_3_70_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-017-1119-7"},{"key":"e_1_3_3_71_2","doi-asserted-by":"publisher","DOI":"10.1016\/s1367-5931(00)00082-x"},{"key":"e_1_3_3_72_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0048679"},{"key":"e_1_3_3_73_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1978.234.4.E399"},{"key":"e_1_3_3_74_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0911295107"},{"key":"e_1_3_3_75_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0572-2"},{"key":"e_1_3_3_76_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkt444"},{"key":"e_1_3_3_77_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI45169"},{"key":"e_1_3_3_78_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0378-1119(98)00396-5"},{"key":"e_1_3_3_79_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0503671102"},{"key":"e_1_3_3_80_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.456590"},{"key":"e_1_3_3_81_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(76)90527-3"}],"container-title":["Infection and Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/IAI.00097-20","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/IAI.00097-20","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,30]],"date-time":"2023-09-30T22:28:58Z","timestamp":1696112938000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/IAI.00097-20"}},"subtitle":[],"editor":[{"given":"Nancy E.","family":"Freitag","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,7,21]]},"references-count":80,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2020,7,21]]}},"alternative-id":["10.1128\/IAI.00097-20"],"URL":"https:\/\/doi.org\/10.1128\/iai.00097-20","relation":{},"ISSN":["0019-9567","1098-5522"],"issn-type":[{"value":"0019-9567","type":"print"},{"value":"1098-5522","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,21]]},"assertion":[{"value":"2020-02-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00097-20"}}