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Following inoculation of the lungs with<jats:italic>C. burnetii<\/jats:italic>Nine Mile phase I (NMI), SCID mice developed pneumonia and splenomegaly and succumbed to infection, whereas wild-type mice cleared the infection by 24 days. SCID mice reconstituted with either CD4<jats:sup>+<\/jats:sup>T cells or CD8<jats:sup>+<\/jats:sup>T cells alone were able to control the infection, indicating that the presence of either type of T cells was sufficient to control infection, and B cells were not necessary for primary immunity. Similarly, wild-type mice depleted of either CD4<jats:sup>+<\/jats:sup>T cells or CD8<jats:sup>+<\/jats:sup>T cells controlled infections in their lungs, but these mice were highly susceptible if they were depleted of both types of T cells. However, compared to CD4<jats:sup>+<\/jats:sup>T-cell-dependent protection, CD8<jats:sup>+<\/jats:sup>T-cell-dependent protection resulted in less inflammation in the lungs and less growth of bacteria in the spleens.<\/jats:p>","DOI":"10.1128\/iai.00101-10","type":"journal-article","created":{"date-parts":[[2010,3,30]],"date-time":"2010-03-30T03:28:48Z","timestamp":1269919728000},"page":"3019-3026","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":74,"title":["Role of CD4<sup>+<\/sup>and CD8<sup>+<\/sup>T Cells in Clearance of Primary Pulmonary Infection with<i>Coxiella burnetii<\/i>"],"prefix":"10.1128","volume":"78","author":[{"given":"Amanda J.","family":"Read","sequence":"first","affiliation":[{"name":"Department of Veterinary Molecular Biology, Montana State University, P.O. 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