{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T13:33:30Z","timestamp":1789911210639,"version":"4.0.1"},"reference-count":51,"publisher":"American Society for Microbiology","issue":"9","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["AI071752"],"award-info":[{"award-number":["AI071752"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["G12MD00759"],"award-info":[{"award-number":["G12MD00759"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000183","name":"DOD | Army Research Office","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000183","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Conventional dendritic cells (cDCs) are critical for protection against pulmonary infection with the opportunistic fungal pathogen\n            <jats:named-content content-type=\"genus-species\">Cryptococcus neoformans<\/jats:named-content>\n            ; however, the role of plasmacytoid dendritic cells (pDCs) is unknown. We show for the first time that murine pDCs have direct activity against\n            <jats:named-content content-type=\"genus-species\">C. neoformans<\/jats:named-content>\n            via reactive oxygen species (ROS), a mechanism different from that employed to control\n            <jats:named-content content-type=\"genus-species\">Aspergillus fumigatus<\/jats:named-content>\n            infections. The anticryptococcal activity of murine pDCs is independent of opsonization but appears to require the C-type lectin receptor Dectin-3, a receptor not previously evaluated during cryptococcal infections. Human pDCs can also inhibit cryptococcal growth by a mechanism similar to that of murine pDCs. Experimental pulmonary infection of mice with a\n            <jats:named-content content-type=\"genus-species\">C. neoformans<\/jats:named-content>\n            strain that induces protective immunity demonstrated that recruitment of pDCs to the lungs is CXCR3 dependent. Taken together, our results show that pDCs inhibit\n            <jats:named-content content-type=\"genus-species\">C. neoformans<\/jats:named-content>\n            growth\n            <jats:italic>in vitro<\/jats:italic>\n            via the production of ROS and that Dectin-3 is required for optimal growth-inhibitory activity.\n          <\/jats:p>","DOI":"10.1128\/iai.00103-16","type":"journal-article","created":{"date-parts":[[2016,6,22]],"date-time":"2016-06-22T03:05:52Z","timestamp":1466564752000},"page":"2493-2504","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":40,"title":["Antifungal Activity of Plasmacytoid Dendritic Cells against Cryptococcus neoformans\n            <i>In Vitro<\/i>\n            Requires Expression of Dectin-3 (CLEC4D) and Reactive Oxygen Species"],"prefix":"10.1128","volume":"84","author":[{"given":"Camaron R.","family":"Hole","sequence":"first","affiliation":[{"name":"Department of Biology, The University of Texas at San Antonio, San Antonio, Texas, USA"},{"name":"South Texas Center for Emerging Infectious Diseases, The University of Texas at San Antonio, San Antonio, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chrissy M.","family":"Leopold Wager","sequence":"additional","affiliation":[{"name":"Department of Biology, The University of Texas at San Antonio, San Antonio, Texas, USA"},{"name":"South Texas Center for Emerging Infectious Diseases, The University of Texas at San Antonio, San Antonio, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew S.","family":"Mendiola","sequence":"additional","affiliation":[{"name":"Department of Biology, The University of Texas at San Antonio, San Antonio, Texas, USA"},{"name":"South Texas Center for Emerging Infectious Diseases, The University of Texas at San Antonio, San Antonio, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen 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