{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T22:34:32Z","timestamp":1790375672461,"version":"4.1.0"},"reference-count":35,"publisher":"American Society for Microbiology","issue":"7","license":[{"start":{"date-parts":[[2007,7,1]],"date-time":"2007-07-01T00:00:00Z","timestamp":1183248000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2007,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Regulation of bacterial gene expression by small RNA (sRNA) molecules is an increasingly recognized phenomenon but one that is not yet fully understood. We show that the sRNA RyhB suppresses several virulence-associated phenotypes of\n            <jats:italic>Shigella dysenteriae<\/jats:italic>\n            , a causative agent of bacillary dysentery in humans. The virulence genes repressed by\n            <jats:italic>S. dysenteriae<\/jats:italic>\n            RyhB include those encoding the type III secretion apparatus, its secreted effectors, and specific chaperones. Suppression of\n            <jats:italic>Shigella<\/jats:italic>\n            virulence occurs via RyhB-dependent repression of the transcriptional activator VirB, leading to reduced expression of genes within the VirB regulon. Efficient repression of\n            <jats:italic>virB<\/jats:italic>\n            is mediated by a single-stranded region of RyhB that is distinct from the region required for repression of\n            <jats:italic>Shigella sodB<\/jats:italic>\n            . Regulation of\n            <jats:italic>virB<\/jats:italic>\n            by RyhB implicates iron as an environmental factor contributing to the complex regulation of\n            <jats:italic>Shigella<\/jats:italic>\n            virulence determinants.\n          <\/jats:p>","DOI":"10.1128\/iai.00112-07","type":"journal-article","created":{"date-parts":[[2007,4,17]],"date-time":"2007-04-17T00:35:40Z","timestamp":1176770140000},"page":"3470-3477","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":120,"title":["RyhB, an Iron-Responsive Small RNA Molecule, Regulates\n            <i>Shigella dysenteriae<\/i>\n            Virulence"],"prefix":"10.1128","volume":"75","author":[{"given":"Erin R.","family":"Murphy","sequence":"first","affiliation":[{"name":"University of Texas at Austin, Section of Molecular Genetics and Microbiology, 1 University Station, A5000, Austin, Texas 78712"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shelley M.","family":"Payne","sequence":"additional","affiliation":[{"name":"University of Texas at Austin, Section of Molecular Genetics and Microbiology, 1 University Station, A5000, Austin, Texas 78712"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.1989.tb00210.x"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gki313"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.169.10.4759-4764.1987"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1986.tb04256.x"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.micro.54.1.519"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.1998.00902.x"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7600058"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.32.1.137-144.1981"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.65.2.818-821.1997"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkg297"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tig.2005.03.007"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.femsre.2003.07.002"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0966-842X(03)00118-5"},{"key":"e_1_3_2_15_2","first-page":"110","volume":"43","year":"2005","unstructured":"Jones, B. 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