{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T22:53:29Z","timestamp":1782514409524,"version":"3.54.5"},"reference-count":50,"publisher":"American Society for Microbiology","issue":"10","license":[{"start":{"date-parts":[[2020,9,18]],"date-time":"2020-09-18T00:00:00Z","timestamp":1600387200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,9,18]],"date-time":"2020-09-18T00:00:00Z","timestamp":1600387200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100005369","name":"Udenrigsministeriet","doi-asserted-by":"publisher","award":["14-P01-GHA"],"award-info":[{"award-number":["14-P01-GHA"]}],"id":[{"id":"10.13039\/501100005369","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2020,9,18]]},"abstract":"<jats:p>\n            Naturally acquired immunity to\n            <jats:named-content content-type=\"genus-species\">Plasmodium falciparum<\/jats:named-content>\n            malaria is thought to be nonsterile and sustained by persistence of low-level parasitemia. This study assessed the association between baseline microscopic and submicroscopic asymptomatic\n            <jats:named-content content-type=\"genus-species\">P. falciparum<\/jats:named-content>\n            infections and antimalarial antibody levels and whether these parasitemia modify protective associations between antibody levels and malaria in Ghanaian children. Healthy children (\n            <jats:italic>N<\/jats:italic>\n            \u2009=\u2009973, aged 0.\n          <\/jats:p>","DOI":"10.1128\/iai.00125-20","type":"journal-article","created":{"date-parts":[[2020,7,28]],"date-time":"2020-07-28T12:40:37Z","timestamp":1595940037000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":15,"title":["Microscopic and Submicroscopic Asymptomatic Plasmodium falciparum Infections in Ghanaian Children and Protection against Febrile Malaria"],"prefix":"10.1128","volume":"88","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3622-2137","authenticated-orcid":false,"given":"Bright","family":"Adu","sequence":"first","affiliation":[{"name":"Department of Immunology, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quratul-ain","family":"Issahaque","sequence":"additional","affiliation":[{"name":"Department of Immunology, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracy","family":"Sarkodie-Addo","sequence":"additional","affiliation":[{"name":"Department of Immunology, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selassie","family":"Kumordjie","sequence":"additional","affiliation":[{"name":"Department of Immunology, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Kyei-Baafour","sequence":"additional","affiliation":[{"name":"Department of Immunology, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caleb K.","family":"Sinclear","sequence":"additional","affiliation":[{"name":"Department of Immunology, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophia","family":"Eyia-Ampah","sequence":"additional","affiliation":[{"name":"Department of Immunology, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eunice","family":"Owusu-Yeboa","sequence":"additional","affiliation":[{"name":"Department of Immunology, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Theisen","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry and Immunology, Statens Serum Institut, Copenhagen, Denmark"},{"name":"Centre for Medical Parasitology at Department of International Health, Immunology, and Microbiology and Department of Infectious Diseases, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Dodoo","sequence":"additional","affiliation":[{"name":"Department of Immunology, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.30875\/f309483f-en"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1711.2002.01107.x"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00025-08"},{"key":"e_1_3_2_5_2","first-page":"786","article-title":"Definition of immunity and premunition","volume":"79","author":"Sergent E","year":"1950","unstructured":"Sergent E. 1950. Definition of immunity and premunition. Ann Inst Pasteur (Paris) 79:786\u2013797.","journal-title":"Ann Inst Pasteur (Paris)"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0035-9203(99)90329-2"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1002729"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0004383"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-019-1255-3"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiz510"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2014.02.004"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0030444"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(18)30348-7"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.4103\/0972-9062.249128"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0141-9838.2004.00678.x"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000218"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12936-016-1146-4"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12936-016-1519-8"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01358-08"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofv044"},{"key":"e_1_3_2_21_2","volume-title":"2016 annual health report","author":"Ghana Health Service","year":"2017","unstructured":"Ghana Health Service. 2017. 2016 annual health report. Ghana Health Service, Accra, Ghana."},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.14-0312"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0118901"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiw057"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-6-131"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0134061"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2015.08.005"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-13-244"},{"key":"e_1_3_2_29_2","volume-title":"Current topics in anemia","author":"Mavondo GA","year":"2017","unstructured":"Mavondo GA, Mzingwane ML. 2017. Severe malarial anemia (SMA) pathophysiology and the use of phytotherapeutics as treatment options. Khan J (ed), Current topics in anemia. IntechOpen, London, UK."},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V95.4.1481.004k15_1481_1486"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12936-018-2221-9"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/0169-4758(95)80167-7"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1080\/00034989859366"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.trstmh.2004.03.010"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-7-193"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3156.2004.01277.x"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw849"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2006.10.014"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1086\/526529"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiv088"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0169-4758(98)01228-9"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.2006.00808.x"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1086\/591467"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2460"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aax4489"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2016.06.014"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0046197"},{"key":"e_1_3_2_48_2","first-page":"127","article-title":"Characterization of the humoral immune response in Plasmodium falciparum malaria. I. Estimation of antibodies to P. falciparum or human erythrocytes by means of microELISA","volume":"54","author":"Wahlgren M","year":"1983","unstructured":"Wahlgren M, Berzins K, Perlmann P, Bjorkman A. 1983. Characterization of the humoral immune response in Plasmodium falciparum malaria. I. Estimation of antibodies to P. falciparum or human erythrocytes by means of microELISA. Clin Exp Immunol 54:127\u2013134.","journal-title":"Clin Exp Immunol"},{"key":"e_1_3_2_49_2","first-page":"506","article-title":"Chelex 100 as a medium for simple extraction of DNA for PCR-based typing from forensic material","volume":"10","author":"Walsh PS","year":"1991","unstructured":"Walsh PS, Metzger DA, Higuchi R. 1991. Chelex 100 as a medium for simple extraction of DNA for PCR-based typing from forensic material. Biotechniques 10:506\u2013513.","journal-title":"Biotechniques"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1179\/000349803125002977"},{"key":"e_1_3_2_51_2","volume-title":"R: A language and environment for statistical computing","author":"R Core Team","year":"2019","unstructured":"R Core Team. 2019. R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. https:\/\/www.R-project.org\/."}],"container-title":["Infection and Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/IAI.00125-20","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/IAI.00125-20","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T11:36:13Z","timestamp":1646480173000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/IAI.00125-20"}},"subtitle":[],"editor":[{"given":"Jeroen P. J.","family":"Saeij","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,9,18]]},"references-count":50,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2020,9,18]]}},"alternative-id":["10.1128\/IAI.00125-20"],"URL":"https:\/\/doi.org\/10.1128\/iai.00125-20","relation":{},"ISSN":["0019-9567","1098-5522"],"issn-type":[{"value":"0019-9567","type":"print"},{"value":"1098-5522","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,18]]},"assertion":[{"value":"2020-03-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00125-20"}}