{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T15:59:24Z","timestamp":1761580764744},"reference-count":36,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[2010,6,1]],"date-time":"2010-06-01T00:00:00Z","timestamp":1275350400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2010,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Genetic linkage studies of the host response to\n            <jats:italic>Leishmania major<\/jats:italic>\n            , the causative agent of cutaneous leishmaniasis, have identified significant genetic complexity in humans and mice. In the mouse model, multiple loci have been implicated in susceptibility to infection, but to date, the genes underlying these loci have not been identified. We now describe the contribution of a novel candidate gene,\n            <jats:italic>Fli1<\/jats:italic>\n            , to both\n            <jats:italic>L. major<\/jats:italic>\n            resistance and enhanced wound healing. We have previously mapped the\n            <jats:italic>L. major<\/jats:italic>\n            response locus,\n            <jats:italic>lmr2<\/jats:italic>\n            , to proximal chromosome 9 in a genetic cross between the resistant C57BL\/6 strain and the susceptible BALB\/c strain. We now show that the presence of the resistant C57BL\/6\n            <jats:italic>lmr2<\/jats:italic>\n            allele in susceptible BALB\/c mice confers an enhanced\n            <jats:italic>L. major<\/jats:italic>\n            resistance and wound healing phenotype. Fine mapping of the\n            <jats:italic>lmr2<\/jats:italic>\n            locus permitted the localization of the\n            <jats:italic>lmr2<\/jats:italic>\n            quantitative trait locus to a 5-Mb interval comprising 21 genes, of which microarray analysis was able to identify differential expression in 1 gene\u2014\n            <jats:italic>Fli1<\/jats:italic>\n            . Analysis of\n            <jats:italic>Fli1<\/jats:italic>\n            expression in wounded and\n            <jats:italic>L. major<\/jats:italic>\n            -infected skin and nai\u0308ve and infected lymph nodes validated the importance of\n            <jats:italic>Fli1<\/jats:italic>\n            in lesion resolution and wound healing and identified 3 polymorphisms in the\n            <jats:italic>Fli1<\/jats:italic>\n            promoter, among which a GA repeat element may be the important contributor.\n          <\/jats:p>","DOI":"10.1128\/iai.00126-10","type":"journal-article","created":{"date-parts":[[2010,4,6]],"date-time":"2010-04-06T00:26:28Z","timestamp":1270513588000},"page":"2734-2744","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":30,"title":["Fine Mapping of\n            <i>Leishmania major<\/i>\n            Susceptibility Locus\n            <i>lmr2<\/i>\n            and Evidence of a Role for\n            <i>Fli1<\/i>\n            in Disease and Wound Healing"],"prefix":"10.1128","volume":"78","author":[{"given":"Anuratha","family":"Sakthianandeswaren","sequence":"first","affiliation":[{"name":"Infection and Immunity Division, The Walter and Eliza Hall Institute, 1G Royal Parade, Parkville 3050, Victoria, Australia"},{"name":"Department of Medical Biology, University of Melbourne, Parkville 3050, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joan M.","family":"Curtis","sequence":"additional","affiliation":[{"name":"Infection and Immunity Division, The Walter and Eliza Hall Institute, 1G Royal Parade, Parkville 3050, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Colleen","family":"Elso","sequence":"additional","affiliation":[{"name":"Infection and Immunity Division, The Walter and Eliza Hall Institute, 1G Royal Parade, Parkville 3050, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beena","family":"Kumar","sequence":"additional","affiliation":[{"name":"Infection and Immunity Division, The Walter and Eliza Hall Institute, 1G Royal Parade, Parkville 3050, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tracey M.","family":"Baldwin","sequence":"additional","affiliation":[{"name":"Infection and Immunity Division, The Walter and Eliza Hall Institute, 1G Royal Parade, Parkville 3050, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sash","family":"Lopaticki","sequence":"additional","affiliation":[{"name":"Infection and Immunity Division, The Walter and Eliza Hall Institute, 1G Royal Parade, Parkville 3050, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lukasz","family":"Kedzierski","sequence":"additional","affiliation":[{"name":"Infection and Immunity Division, The Walter and Eliza Hall Institute, 1G Royal Parade, Parkville 3050, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gordon K.","family":"Smyth","sequence":"additional","affiliation":[{"name":"Infection and Immunity Division, The Walter and Eliza Hall Institute, 1G Royal Parade, Parkville 3050, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon J.","family":"Foote","sequence":"additional","affiliation":[{"name":"Menzies Research Institute, 17 Liverpool St., Hobart 7000, Tasmania, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emanuela","family":"Handman","sequence":"additional","affiliation":[{"name":"Infection and Immunity Division, The Walter and Eliza Hall Institute, 1G Royal Parade, Parkville 3050, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","first-page":"1","volume":"8","year":"2003","unstructured":"Alrajhi, A. 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