{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T05:10:45Z","timestamp":1789103445267,"version":"build-2803163510"},"reference-count":50,"publisher":"American Society for Microbiology","issue":"8","license":[{"start":{"date-parts":[[2022,8,18]],"date-time":"2022-08-18T00:00:00Z","timestamp":1660780800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/doi.org\/10.1128\/ASMCopyrightv2"},{"start":{"date-parts":[[2022,8,18]],"date-time":"2022-08-18T00:00:00Z","timestamp":1660780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"Sophia Scientific Research Foundation","award":["S15-33"],"award-info":[{"award-number":["S15-33"]}]},{"name":"Sophia Scientific Research Foundation","award":["S18-04"],"award-info":[{"award-number":["S18-04"]}]},{"name":"Coolsingel Foundation","award":["503"],"award-info":[{"award-number":["503"]}]},{"name":"Chinese Scholarships Council","award":["202003250071"],"award-info":[{"award-number":["202003250071"]}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2022,8,18]]},"abstract":"<jats:p><jats:named-content content-type=\"genus-species\">Mycoplasma pneumoniae<\/jats:named-content>and<jats:named-content content-type=\"genus-species\">Streptococcus pneumoniae<\/jats:named-content>are the most common bacterial causes of pneumonia in children. The clinical characteristics of pneumonia differ significantly between the two bacteria. We aimed to elucidate the differences in pathogenesis between<jats:named-content content-type=\"genus-species\">M. pneumoniae<\/jats:named-content>and<jats:named-content content-type=\"genus-species\">S. pneumoniae<\/jats:named-content>by characterizing the respiratory epithelial cell immune response to both pathogens.<\/jats:p>","DOI":"10.1128\/iai.00129-22","type":"journal-article","created":{"date-parts":[[2022,7,11]],"date-time":"2022-07-11T13:00:38Z","timestamp":1657544438000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":13,"title":["Mycoplasma pneumoniae Compared to Streptococcus pneumoniae Avoids Induction of Proinflammatory Epithelial Cell Responses despite Robustly Inducing TLR2 Signaling"],"prefix":"10.1128","volume":"90","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5071-2781","authenticated-orcid":true,"given":"R. C. A.","family":"de Groot","sequence":"first","affiliation":[{"name":"Laboratory of Pediatrics, Division of Pediatric Infectious Diseases and Immunology, Erasmus MC University Medical Center Rotterdam\u2013Sophia Children\u2019s Hospital, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Zhu","sequence":"additional","affiliation":[{"name":"Laboratory of Pediatrics, Division of Pediatric Infectious Diseases and Immunology, Erasmus MC University Medical Center Rotterdam\u2013Sophia Children\u2019s Hospital, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Hoogenboezem","sequence":"additional","affiliation":[{"name":"Laboratory of Pediatrics, Division of Pediatric Infectious Diseases and Immunology, Erasmus MC University Medical Center Rotterdam\u2013Sophia Children\u2019s Hospital, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. C. J. M.","family":"de Bruijn","sequence":"additional","affiliation":[{"name":"Laboratory of Pediatrics, Division of Pediatric Infectious Diseases and Immunology, Erasmus MC University Medical Center Rotterdam\u2013Sophia Children\u2019s Hospital, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Eenjes","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery and Department of Cell Biology, Erasmus MC University Medical Center Rotterdam\u2013Sophia Children\u2019s Hospital, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. E. J.","family":"\u2019t Jong","sequence":"additional","affiliation":[{"name":"Alternatives Unit, Biomedical Primate Research Centre, Rijswijk, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. I.","family":"Belo","sequence":"additional","affiliation":[{"name":"Laboratory of Pediatrics, Division of Pediatric Infectious Diseases and Immunology, Erasmus MC University Medical Center Rotterdam\u2013Sophia Children\u2019s Hospital, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. C.","family":"Estev\u00e3o","sequence":"additional","affiliation":[{"name":"Laboratory of Pediatrics, Division of Pediatric Infectious Diseases and Immunology, Erasmus MC University Medical Center Rotterdam\u2013Sophia Children\u2019s Hospital, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. J.","family":"Bajramovic","sequence":"additional","affiliation":[{"name":"Alternatives Unit, Biomedical Primate Research Centre, Rijswijk, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. J.","family":"Rottier","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery and Department of Cell Biology, Erasmus MC University Medical Center Rotterdam\u2013Sophia Children\u2019s Hospital, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Kool","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. M. C.","family":"van Rossum","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Pediatric Infectious Diseases and Immunology, Erasmus MC University Medical Center Rotterdam\u2013Sophia Children\u2019s Hospital, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. W. J.","family":"Unger","sequence":"additional","affiliation":[{"name":"Laboratory of Pediatrics, Division of Pediatric Infectious Diseases and Immunology, Erasmus MC University Medical Center Rotterdam\u2013Sophia Children\u2019s Hospital, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","unstructured":"World Health Organization. 2016. Pneumonia fact sheet. World Health Organization Geneva Switzerland. Accessed 16 April 2018."},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1405870"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0163-4453(17)30198-6"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciz1059"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1843.2006.00927.x"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2017.71"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.7.4641"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01961-14"},{"key":"e_1_3_3_10_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4049\/jimmunol.163.1.1","article-title":"Cutting edge: recognition of Gram-positive bacterial cell wall components by the innate immune system occurs via Toll-like receptor 2","volume":"163","author":"Yoshimura A","year":"1999","unstructured":"Yoshimura A, Lien E, Ingalls RR, Tuomanen E, Dziarski R, Golenbock D. 1999. Cutting edge: recognition of Gram-positive bacterial cell wall components by the innate immune system occurs via Toll-like receptor 2. J Immunol 163:1\u20135.","journal-title":"J Immunol"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0435928100"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2009.09.018"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.169.1.10"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/13.7.933"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.5.2942"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature03253"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200425336"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1410293111"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1359-6101(03)00049-2"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2013-0114OC"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02202-17"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.03.00098803"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.17.4.697-728.2004"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0901888"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/s1567-1348(02)00151-x"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-11005-2"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.09.032"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.2500\/aap.2009.30.3207"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2015.07.007"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20112691"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0012-3692(15)37964-2"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.70.7.3649-3655.2002"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciy419"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000001364"},{"key":"e_1_3_3_35_2","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1183\/09031936.93.01040324","article-title":"Clinical diagnosis of pneumococcal, adenoviral, mycoplasmal and mixed pneumonias in young men","volume":"1","author":"Lehtomaki K","year":"1988","unstructured":"Lehtomaki K. 1988. Clinical diagnosis of pneumococcal, adenoviral, mycoplasmal and mixed pneumonias in young men. Eur Respir J 1:324\u2013329.","journal-title":"Eur Respir J"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(89)80476-4"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-10-39"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001444"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.09.008"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.292235"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2003-0329OC"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.453266"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2180-14-156"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa044113"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0804181105"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1086\/653121"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200709-1387OC"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1086\/392498"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2180-8-167"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01009-2017"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00234.2020"}],"container-title":["Infection and Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/iai.00129-22","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/iai.00129-22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,11]],"date-time":"2023-02-11T08:53:11Z","timestamp":1676105591000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/iai.00129-22"}},"subtitle":[],"editor":[{"given":"Liise-anne","family":"Pirofski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,8,18]]},"references-count":50,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2022,8,18]]}},"alternative-id":["10.1128\/iai.00129-22"],"URL":"https:\/\/doi.org\/10.1128\/iai.00129-22","relation":{},"ISSN":["0019-9567","1098-5522"],"issn-type":[{"value":"0019-9567","type":"print"},{"value":"1098-5522","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,18]]},"assertion":[{"value":"2022-03-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00129-22"}}