{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T08:45:54Z","timestamp":1791017154062,"version":"4.1.0"},"reference-count":61,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T00:00:00Z","timestamp":1306886400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2011,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Fibronectin-binding protein A (FnBPA) and FnBPB are important adhesins for\n                    <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Staphylococcus aureus<\/jats:named-content>\n                    infection. We constructed\n                    <jats:italic>fnbA<\/jats:italic>\n                    and\/or\n                    <jats:italic>fnbB<\/jats:italic>\n                    mutant strains from\n                    <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">S. aureus<\/jats:named-content>\n                    SH1000, which possesses intact\n                    <jats:italic>rsbU<\/jats:italic>\n                    , and studied the role of these adhesins in\n                    <jats:italic>in vitro<\/jats:italic>\n                    and\n                    <jats:italic>in vivo<\/jats:italic>\n                    infections. In intravenous infection, all\n                    <jats:italic>fnb<\/jats:italic>\n                    mutants caused a remarkable reduction in the colonization rate in kidneys and the mortality rate of mice.\n                    <jats:italic>fnbB<\/jats:italic>\n                    mutant caused a more severe decrease in body weight than that caused by\n                    <jats:italic>fnbA<\/jats:italic>\n                    mutant. Serum levels of interleukin-6 and nuclear factor \u03baB (NF-\u03baB) activation in spleen cells were remarkably reduced in\n                    <jats:italic>fnbA<\/jats:italic>\n                    or\n                    <jats:italic>fnbA fnbB<\/jats:italic>\n                    mutant infections; however, there was no significant reduction in\n                    <jats:italic>fnbB<\/jats:italic>\n                    mutant infections. In\n                    <jats:italic>in vitro<\/jats:italic>\n                    cellular infection, FnBPA was shown to be indispensable for adhesion to and internalization by nonprofessional phagocytic cells upon ingestion by inflammatory macrophages and NF-\u03baB activation. However, both FnBPs were required for efficient cellular responses. The results showed that FnBPA is more important for\n                    <jats:italic>in vitro<\/jats:italic>\n                    and\n                    <jats:italic>in vivo<\/jats:italic>\n                    infections; however, cooperation between FnBPA and FnBPB is indispensable for the induction of severe infection resulting in septic death.\n                  <\/jats:p>","DOI":"10.1128\/iai.00133-11","type":"journal-article","created":{"date-parts":[[2011,3,22]],"date-time":"2011-03-22T00:46:16Z","timestamp":1300754776000},"page":"2215-2223","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":95,"title":["Role of Fibronectin-Binding Proteins A and B in\n                    <i>In Vitro<\/i>\n                    Cellular Infections and\n                    <i>In Vivo<\/i>\n                    Septic Infections by Staphylococcus aureus"],"prefix":"10.1128","volume":"79","author":[{"given":"Hitomi","family":"Shinji","sequence":"first","affiliation":[{"name":"Department of Bacteriology, The Jikei University School of Medicine, Tokyo 105-8461, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukio","family":"Yosizawa","sequence":"additional","affiliation":[{"name":"Radioisotope Research Facilities, The Jikei University School of Medicine, Tokyo 105-8461, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiko","family":"Tajima","sequence":"additional","affiliation":[{"name":"Department of Bacteriology, The Jikei University School of Medicine, Tokyo 105-8461, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadayuki","family":"Iwase","sequence":"additional","affiliation":[{"name":"Department of Bacteriology, The Jikei University School of Medicine, Tokyo 105-8461, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinya","family":"Sugimoto","sequence":"additional","affiliation":[{"name":"Department of Bacteriology, The Jikei University School of Medicine, Tokyo 105-8461, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiko","family":"Seki","sequence":"additional","affiliation":[{"name":"Division of Fine Morphology, The Jikei University School of Medicine, Tokyo 105-8461, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshimitsu","family":"Mizunoe","sequence":"additional","affiliation":[{"name":"Department of Bacteriology, The Jikei University School of Medicine, Tokyo 105-8461, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.02328"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-695X.2005.00021.x"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200101043440110"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.186.13.4085-4099.2004"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2004.03.008"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2180-10-160"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1086\/606011"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature01326"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00350-08"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000964"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.73.2.990-998.2005"},{"key":"e_1_3_2_13_2","doi-asserted-by":"crossref","first-page":"3815","DOI":"10.4049\/jimmunol.147.11.3815","article-title":"IL-10 inhibits cytokine production by activated macrophages","volume":"147","author":"Fiorentino D. 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