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To identify endometrial innate immune components that interact with<jats:italic>Chlamydia<\/jats:italic>, we introduced<jats:named-content content-type=\"genus-species\">C. trachomatis<\/jats:named-content>into mouse endometrium via transcervical inoculation and compared the infectious yields in mice with and without immunodeficiency. Live<jats:named-content content-type=\"genus-species\">C. trachomatis<\/jats:named-content>recovered from vaginal swabs or endometrial tissues peaked on day 3 and then declined in all mice with or without deficiency in adaptive immunity, indicating a critical role for innate immunity in endometrial control of<jats:named-content content-type=\"genus-species\">C. trachomatis<\/jats:named-content>infection.<\/jats:p>","DOI":"10.1128\/iai.00152-20","type":"journal-article","created":{"date-parts":[[2020,4,23]],"date-time":"2020-04-23T14:26:37Z","timestamp":1587651997000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":24,"title":["Innate Lymphoid Cells Are Required for Endometrial Resistance to<i>Chlamydia trachomatis<\/i>Infection"],"prefix":"10.1128","volume":"88","author":[{"given":"Hong","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Obstetrics, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China"},{"name":"Department of Gynecology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China"},{"name":"Department of Microbiology, Immunology and Molecular Genetics, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China"},{"name":"Department of Gynecology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China"},{"name":"Department of Microbiology, Immunology and Molecular Genetics, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujie","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China"},{"name":"Department of Gynecology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China"},{"name":"Department of Microbiology, Immunology and Molecular Genetics, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingli","family":"Tang","sequence":"additional","affiliation":[{"name":"Laboratory Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianlin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China"},{"name":"Department of Gynecology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangming","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology and Molecular Genetics, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","volume-title":"Sexually transmitted disease surveillance, 2016","author":"Centers for Disease Control and Prevention","year":"2017","unstructured":"Centers for Disease Control and Prevention. 2017. 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