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Colonization of the maternal decidua appears to be an initial step in the maternal component of the disease as well as bacterial transmission to the placenta and fetus. Host-pathogen interactions in the decidua during this early stage of infection remain poorly understood. Here, we assessed the dynamics of<jats:named-content content-type=\"genus-species\">L. monocytogenes<\/jats:named-content>infection in primary human decidual organ cultures and in the murine decidua<jats:italic>in vivo<\/jats:italic>. A high inoculum was necessary to infect both human and mouse deciduas, and the data support the existence of a barrier to initial colonization of the murine decidua. If successful, however, colonization in both species was followed by significant bacterial expansion associated with an inability of the decidua to mount appropriate innate cellular immune responses. The innate immune deficits included the failure of bacterial foci to attract macrophages and NK cells, cell types known to be important for early defenses against<jats:named-content content-type=\"genus-species\">L. monocytogenes<\/jats:named-content>in the spleen, as well as a decrease in the tissue density of inflammatory Ly6C<jats:sup>hi<\/jats:sup>monocytes<jats:italic>in vivo<\/jats:italic>. These results suggest that the infectivity of the decidua is not the result of an enhanced recruitment of<jats:named-content content-type=\"genus-species\">L. monocytogenes<\/jats:named-content>to the gestational uterus but rather is due to compromised local innate cellular immune responses.<\/jats:p>","DOI":"10.1128\/iai.00153-17","type":"journal-article","created":{"date-parts":[[2017,5,16]],"date-time":"2017-05-16T00:50:17Z","timestamp":1494895817000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":14,"title":["Limited Colonization Undermined by Inadequate Early Immune Responses Defines the Dynamics of Decidual Listeriosis"],"prefix":"10.1128","volume":"85","author":[{"given":"Gabrielle","family":"Rizzuto","sequence":"first","affiliation":[{"name":"Benioff Children's Hospital and Program in Microbial Pathogenesis and Host Defense, University of California\u2014San Francisco, San Francisco, California, USA"},{"name":"Biomedical Sciences Program, University of California\u2014San Francisco, San Francisco, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Tagliani","sequence":"additional","affiliation":[{"name":"Department of Pathology, NYU School of Medicine, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priyanka","family":"Manandhar","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, University of California\u2014San Francisco, San Francisco, California, USA"},{"name":"Immunology Program, University of California\u2014San Francisco, San Francisco, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian","family":"Erlebacher","sequence":"additional","affiliation":[{"name":"Biomedical Sciences Program, University of California\u2014San Francisco, San Francisco, California, USA"},{"name":"Department of Pathology, NYU School of Medicine, New York, New York, USA"},{"name":"Immunology Program, University of California\u2014San Francisco, San Francisco, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna I.","family":"Bakardjiev","sequence":"additional","affiliation":[{"name":"Benioff Children's Hospital and Program in Microbial Pathogenesis and Host Defense, University of California\u2014San Francisco, San Francisco, California, USA"},{"name":"Biomedical Sciences Program, University of California\u2014San Francisco, San Francisco, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-991042"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-032712-100003"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000732"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01186-09"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.05899-11"},{"key":"e_1_3_3_7_2","doi-asserted-by":"crossref","first-page":"3947","DOI":"10.4049\/jimmunol.140.11.3947","article-title":"Specific defects in the anti-listerial immune response in discrete regions of the murine uterus and placenta account for susceptibility to infection","volume":"140","author":"Redline RW","year":"1988","unstructured":"Redline RW Lu CY . 1988. Specific defects in the anti-listerial immune response in discrete regions of the murine uterus and placenta account for susceptibility to infection. 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