{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:50:21Z","timestamp":1791309021496,"version":"4.3.1"},"reference-count":44,"publisher":"American Society for Microbiology","issue":"9","license":[{"start":{"date-parts":[[2009,9,1]],"date-time":"2009-09-01T00:00:00Z","timestamp":1251763200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2009,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>The underlying mechanisms of the epidemiological association between influenza virus infections and<jats:italic>Neisseria meningitidis<\/jats:italic>invasive infections are not fully understood. Here we report that adhesion of<jats:italic>N. meningitidis<\/jats:italic>to human Hec-1-B epithelial cells is enhanced by influenza A virus (IAV) infection. A potential role of the viral neuraminidase (NA) in facilitating meningococcal adhesion to influenza virus-infected epithelial cells was examined. Expression of a recombinant IAV NA in Hec-1-B human epithelial cells increased the adhesion of strains of<jats:italic>N. meningitidis<\/jats:italic>belonging to the sialic acid-containing capsular serogroups B, C, and W135 but not to the mannosamine phosphate-containing capsular serogroup A. Adhesion enhancement was not observed with an inactive NA mutant or in the presence of an NA inhibitor (zanamivir). Furthermore, purified IAV NA was shown to cleave sialic acid-containing capsular polysaccharides of<jats:italic>N. meningitidis<\/jats:italic>. On the whole, our findings suggest that a direct interaction between the NA of IAV and the capsule of<jats:italic>N. meningitidis<\/jats:italic>enhances bacterial adhesion to cultured epithelial cells, most likely through cleavage of capsular sialic acid-containing polysaccharides. A better understanding of the association between IAV and invasive meningococcal infections should help to set up improved control strategies against these seasonal dual viral-bacterial infections.<\/jats:p>","DOI":"10.1128\/iai.00155-09","type":"journal-article","created":{"date-parts":[[2009,6,16]],"date-time":"2009-06-16T00:49:52Z","timestamp":1245113392000},"page":"3588-3595","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":60,"title":["Influenza A Virus Neuraminidase Enhances Meningococcal Adhesion to Epithelial Cells through Interaction with Sialic Acid-Containing Meningococcal Capsules"],"prefix":"10.1128","volume":"77","author":[{"given":"Marie-Anne","family":"Rameix-Welti","sequence":"first","affiliation":[{"name":"Unite\u0301 de Ge\u0301ne\u0301tique Mole\u0301culaire des Virus a\u0300 ARN, Centre National de Re\u0301fe\u0301rence du Virus Influenzae (Re\u0301gion Nord), Institut Pasteur, CNRS URA 3015, Universite\u0301 Paris Diderot-Paris 7, 25-28 rue du Dr. Roux, 75724 Paris Cedex 15, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Leticia","family":"Zarantonelli","sequence":"additional","affiliation":[{"name":"Unite\u0301 Neisseria, Centre National de Re\u0301fe\u0301rence des Me\u0301ningocoques"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dario","family":"Giorgini","sequence":"additional","affiliation":[{"name":"Unite\u0301 Neisseria, Centre National de Re\u0301fe\u0301rence des Me\u0301ningocoques"},{"name":"Unite\u0301 Postulante Infections Bacte\u0301riennes Invasives"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corinne","family":"Ruckly","sequence":"additional","affiliation":[{"name":"Unite\u0301 Neisseria, Centre National de Re\u0301fe\u0301rence des Me\u0301ningocoques"},{"name":"Unite\u0301 Postulante Infections Bacte\u0301riennes Invasives"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Marasescu","sequence":"additional","affiliation":[{"name":"Unite\u0301 de Ge\u0301ne\u0301tique Mole\u0301culaire des Virus a\u0300 ARN, Centre National de Re\u0301fe\u0301rence du Virus Influenzae (Re\u0301gion Nord), Institut Pasteur, CNRS URA 3015, Universite\u0301 Paris Diderot-Paris 7, 25-28 rue du Dr. Roux, 75724 Paris Cedex 15, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"van der Werf","sequence":"additional","affiliation":[{"name":"Unite\u0301 de Ge\u0301ne\u0301tique Mole\u0301culaire des Virus a\u0300 ARN, Centre National de Re\u0301fe\u0301rence du Virus Influenzae (Re\u0301gion Nord), Institut Pasteur, CNRS URA 3015, Universite\u0301 Paris Diderot-Paris 7, 25-28 rue du Dr. Roux, 75724 Paris Cedex 15, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Michel","family":"Alonso","sequence":"additional","affiliation":[{"name":"Unite\u0301 Neisseria, Centre National de Re\u0301fe\u0301rence des Me\u0301ningocoques"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia","family":"Naffakh","sequence":"additional","affiliation":[{"name":"Unite\u0301 de Ge\u0301ne\u0301tique Mole\u0301culaire des Virus a\u0300 ARN, Centre National de Re\u0301fe\u0301rence du Virus Influenzae (Re\u0301gion Nord), Institut Pasteur, CNRS URA 3015, Universite\u0301 Paris Diderot-Paris 7, 25-28 rue du Dr. Roux, 75724 Paris Cedex 15, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhamed-Kheir","family":"Taha","sequence":"additional","affiliation":[{"name":"Unite\u0301 Neisseria, Centre National de Re\u0301fe\u0301rence des Me\u0301ningocoques"},{"name":"Unite\u0301 Postulante Infections Bacte\u0301riennes Invasives"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","first-page":"177","volume":"26","year":"1988","unstructured":"Abdillahi, H., and J. 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