{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T22:12:19Z","timestamp":1789855939090,"version":"4.0.1"},"reference-count":48,"publisher":"American Society for Microbiology","issue":"12","license":[{"start":{"date-parts":[[2010,12,1]],"date-time":"2010-12-01T00:00:00Z","timestamp":1291161600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2010,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>BALB\/c mice are highly susceptible to experimental<jats:italic>Trypanosoma congolense<\/jats:italic>infections, whereas C57BL\/6 mice are relatively resistant. Infected highly susceptible BALB\/c mice die of systemic inflammatory response syndrome. Because interleukin-17 (IL-17) and Th17 cells regulate inflammatory responses, we investigated their role in the pathogenesis of experimental African trypanosomiasis in mice. We show that the production of IL-17 by spleen and liver cells and the serum IL-17 level increased after<jats:italic>T. congolense<\/jats:italic>infection in mice. Interestingly, infected highly susceptible BALB\/c mice produced more IL-17 and had more Th17 cells than infected relatively resistant C57BL\/6 mice. Paradoxically, neutralization of IL-17 with anti-IL-17 monoclonal antibody<jats:italic>in vivo<\/jats:italic>induced higher parasitemia in both the susceptible and the relatively resistant mice. Interestingly, anti-IL-17 antibody-treated mice had higher serum levels of alanine aminotransferase and aspartate aminotransferase, and the production of IL-10 and nitric oxide by liver cells was markedly decreased. Moreover, recombinant IL-17-treated mice exhibited significantly faster parasite control and lower peak parasitemia compared to control mice. Collectively, these results suggest that the IL-17\/Th17 axis plays a protective role in murine experimental African trypanosomiasis.<\/jats:p>","DOI":"10.1128\/iai.00168-10","type":"journal-article","created":{"date-parts":[[2010,9,21]],"date-time":"2010-09-21T04:10:41Z","timestamp":1285042241000},"page":"5271-5279","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":18,"title":["Interleukin-17-Mediated Control of Parasitemia in Experimental<i>Trypanosoma congolense<\/i>Infection in Mice"],"prefix":"10.1128","volume":"78","author":[{"given":"Zhirong","family":"Mou","sequence":"first","affiliation":[{"name":"Department of Immunology, Faculty of Medicine, University of Manitoba, Winnipeg, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Immunology, Faculty of Medicine, University of Manitoba, Winnipeg, 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