{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T05:39:05Z","timestamp":1793338745500,"version":"4.5.0"},"reference-count":52,"publisher":"American Society for Microbiology","issue":"11","license":[{"start":{"date-parts":[[2008,11,1]],"date-time":"2008-11-01T00:00:00Z","timestamp":1225497600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2008,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            <jats:italic>Yersinia pestis<\/jats:italic>\n            , the bacterial agent of plague, secretes several proteins important for pathogenesis or host protection. The F1 protein forms a capsule on the bacterial cell surface and is a well-characterized protective antigen but is not essential for virulence. A type III secretion system that is essential for virulence exports Yop proteins, which function as antiphagocytic or anti-inflammatory factors. Yop effectors (e.g., YopE) are delivered across the host cell plasma membrane by a translocon, composed of YopB and YopD. Complexes of YopB, YopD, and YopE (BDE) secreted by\n            <jats:italic>Yersinia pseudotuberculosis<\/jats:italic>\n            were purified by affinity chromatography and used as immunogens to determine if antibodies to the translocon could provide protection against\n            <jats:italic>Y. pestis<\/jats:italic>\n            in mice. Mice vaccinated with BDE generated high-titer immunoglobulin G antibodies specific for BDE, as shown by enzyme-linked immunosorbent assay and immunoblotting, and were protected against lethal intravenous challenge with F1\n            <jats:sup>\u2212<\/jats:sup>\n            but not F1\n            <jats:sup>+<\/jats:sup>\n            <jats:italic>Y. pestis.<\/jats:italic>\n            Mice passively immunized with anti-BDE serum were protected from lethal challenge with F1\n            <jats:sup>\u2212<\/jats:sup>\n            <jats:italic>Y. pestis<\/jats:italic>\n            . The YopB protein or a complex of YopB and YopD (BD) was purified and determined by vaccination to be immunogenic in mice. Mice actively vaccinated with BD or passively vaccinated with anti-BD serum were protected against lethal challenge with F1\n            <jats:sup>\u2212<\/jats:sup>\n            <jats:italic>Y. pestis<\/jats:italic>\n            . These results indicate that anti-translocon antibodies can be used as immunotherapy to treat infections by F1\n            <jats:sup>\u2212<\/jats:sup>\n            <jats:italic>Y. pestis<\/jats:italic>\n            .\n          <\/jats:p>","DOI":"10.1128\/iai.00189-08","type":"journal-article","created":{"date-parts":[[2008,9,3]],"date-time":"2008-09-03T01:11:35Z","timestamp":1220404295000},"page":"5181-5190","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":41,"title":["Vaccination of Mice with a Yop Translocon Complex Elicits Antibodies That Are Protective against Infection with F1\n            <sup>\u2212<\/sup>\n            <i>Yersinia pestis<\/i>"],"prefix":"10.1128","volume":"76","author":[{"given":"Maya I.","family":"Ivanov","sequence":"first","affiliation":[{"name":"Center for Infectious Diseases and Department of Molecular Genetics and Microbiology, State University of New York at Stony Brook, Stony Brook, New York 11794-5222"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Betty L.","family":"Noel","sequence":"additional","affiliation":[{"name":"Center for Infectious Diseases and Department of Molecular Genetics and Microbiology, State University of New York at Stony Brook, Stony Brook, New York 11794-5222"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan","family":"Rampersaud","sequence":"additional","affiliation":[{"name":"Center for Infectious Diseases and Department of Molecular Genetics and Microbiology, State University of New York at Stony Brook, Stony Brook, New York 11794-5222"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricio","family":"Mena","sequence":"additional","affiliation":[{"name":"Center for Infectious Diseases and Department of Molecular Genetics and Microbiology, State University of New York at Stony Brook, Stony Brook, New York 11794-5222"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge L.","family":"Benach","sequence":"additional","affiliation":[{"name":"Center for Infectious Diseases and Department of Molecular Genetics and Microbiology, State University of New York at Stony Brook, Stony Brook, New York 11794-5222"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James B.","family":"Bliska","sequence":"additional","affiliation":[{"name":"Center for Infectious Diseases and Department of Molecular Genetics and Microbiology, State University of New York at Stony Brook, Stony Brook, New York 11794-5222"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/25.17.3389"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.64.11.4580-4585.1996"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.67.3.1533-1537.1999"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.2000.02021.x"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2007.05871.x"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.71.7.3673-3681.2003"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004300050034"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1086\/507644"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro1526"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.73.9.6127-6137.2005"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01860-05"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.67.10.5395-5408.1999"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature05272"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00255-06"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.72.9.4973-4984.2004"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.70.8.4165-4176.2002"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.61.1.71-80.1993"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.64.6.2308-2314.1996"},{"key":"e_1_3_2_20_2","first-page":"235","volume":"13","year":"1995","unstructured":"Hartland, E. 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