{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T17:16:15Z","timestamp":1788455775404,"version":"build-2803163510"},"reference-count":46,"publisher":"American Society for Microbiology","issue":"10","license":[{"start":{"date-parts":[[2022,10,20]],"date-time":"2022-10-20T00:00:00Z","timestamp":1666224000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,10,20]],"date-time":"2022-10-20T00:00:00Z","timestamp":1666224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["PR181874 W81XWH-19-1-0208"],"award-info":[{"award-number":["PR181874 W81XWH-19-1-0208"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006823","name":"Boston Children's Hospital","doi-asserted-by":"publisher","award":["TIDO"],"award-info":[{"award-number":["TIDO"]}],"id":[{"id":"10.13039\/100006823","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006823","name":"Boston Children's Hospital","doi-asserted-by":"publisher","award":["Richard A. and Susan F. Smith President's Innovation Award"],"award-info":[{"award-number":["Richard A. and Susan F. Smith President's Innovation Award"]}],"id":[{"id":"10.13039\/100006823","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006823","name":"Boston Children's Hospital","doi-asserted-by":"publisher","award":["TRIPPACC"],"award-info":[{"award-number":["TRIPPACC"]}],"id":[{"id":"10.13039\/100006823","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2022,10,20]]},"abstract":"<jats:p>\n                    The Gram-negative pathogen\n                    <jats:named-content content-type=\"genus-species\">Pseudomonas aeruginosa<\/jats:named-content>\n                    is a common cause of pneumonia in hospitalized patients. Its increasing antibiotic resistance and widespread occurrence present a pressing need for vaccines.\n                  <\/jats:p>","DOI":"10.1128\/iai.00203-22","type":"journal-article","created":{"date-parts":[[2022,9,7]],"date-time":"2022-09-07T09:05:04Z","timestamp":1662541504000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":16,"title":["Multicomponent Pseudomonas aeruginosa Vaccines Eliciting Th17 Cells and Functional Antibody Responses Confer Enhanced Protection against Experimental Acute Pneumonia in Mice"],"prefix":"10.1128","volume":"90","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5571-5220","authenticated-orcid":false,"given":"Mohammad Omar Faruk","family":"Shaikh","sequence":"first","affiliation":[{"name":"Division of Critical Care Medicine, Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children\u2019s Hospital, Boston, Massachusetts, USA"},{"name":"Department of Anaesthesia, Harvard Medical School, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7454-4180","authenticated-orcid":true,"given":"Matthew M.","family":"Schaefers","sequence":"additional","affiliation":[{"name":"Division of Critical Care Medicine, Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children\u2019s Hospital, Boston, Massachusetts, USA"},{"name":"Department of Anaesthesia, Harvard Medical School, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2098-599X","authenticated-orcid":false,"given":"Christina","family":"Merakou","sequence":"additional","affiliation":[{"name":"Division of Critical Care Medicine, Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children\u2019s Hospital, Boston, Massachusetts, USA"},{"name":"Department of Anaesthesia, Harvard Medical School, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7336-468X","authenticated-orcid":false,"given":"Marco","family":"DiBlasi","sequence":"additional","affiliation":[{"name":"Division of Critical Care Medicine, Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children\u2019s Hospital, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Bonney","sequence":"additional","affiliation":[{"name":"Division of Critical Care Medicine, Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children\u2019s Hospital, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiffany","family":"Liao","sequence":"additional","affiliation":[{"name":"Division of Critical Care Medicine, Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children\u2019s Hospital, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3610-6942","authenticated-orcid":false,"given":"David","family":"Zurakowski","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia, Harvard Medical School, Boston, Massachusetts, USA"},{"name":"Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children\u2019s Hospital, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"Kehl","sequence":"additional","affiliation":[{"name":"Vaccines and Immune Therapies, Biopharmaceuticals R&amp;D, AstraZeneca, Gaithersburg, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David E.","family":"Tabor","sequence":"additional","affiliation":[{"name":"Vaccines and Immune Therapies, Biopharmaceuticals R&amp;D, AstraZeneca, Gaithersburg, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1745-647X","authenticated-orcid":true,"given":"Antonio","family":"DiGiandomenico","sequence":"additional","affiliation":[{"name":"Vaccines and Immune Therapies, Biopharmaceuticals R&amp;D, AstraZeneca, Gaithersburg, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9831-0354","authenticated-orcid":false,"given":"Gregory P.","family":"Priebe","sequence":"additional","affiliation":[{"name":"Division of Critical Care Medicine, Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children\u2019s Hospital, Boston, Massachusetts, USA"},{"name":"Department of Anaesthesia, Harvard Medical School, Boston, Massachusetts, USA"},{"name":"Division of Infectious Diseases, Department of Pediatrics, Boston Children\u2019s Hospital, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000000510"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1017\/ice.2021.391"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202106-1354OC"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1086\/668770"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000251707.32332.c1"},{"key":"e_1_3_3_7_2","first-page":"352","article-title":"Multidrug- and carbapenem-resistant Pseudomonas aeruginosa in children, United States, 1999\u20132012","volume":"6","author":"Logan LK","year":"2016","unstructured":"Logan LK, Gandra S, Mandal S, Klein EY, Levinson J, Weinstein RA, Laxminarayan R, Program PE. 2016. Multidrug- and carbapenem-resistant Pseudomonas aeruginosa in children, United States, 1999\u20132012. J Pediatric Infect Dis Soc 6:352\u2013359.","journal-title":"J Pediatric Infect Dis Soc"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.98.2.835-836.1969"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1586\/14760584.2014.890053"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.3109\/10408419009105729"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.66.8.3719-3726.1998"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.62.9.3608-3616.1994"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1089\/sur.2018.233"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.67.3.1461-1470.1999"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00054-09"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI23135"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/cei.12101"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0056996"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.4161\/hv.26565"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2010.04.028"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1112422"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-017-1601-9"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-020-2792-z"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201202-0182OC"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2018.10.010"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1099\/00221287-147-10-2659"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiy438"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkq869"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0015131"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0901144"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0903019"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines9070803"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.7.4965"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.2.1097"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2006.03.028"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2007.04.010"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.583008"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1743"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000159"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.194.4.519"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1010430"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00490-18"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni1449"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1086\/422329"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2009.08.080"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20120033"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.28277-0"}],"container-title":["Infection and Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/iai.00203-22","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/iai.00203-22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,20]],"date-time":"2022-10-20T09:29:34Z","timestamp":1666258174000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/iai.00203-22"}},"subtitle":[],"editor":[{"given":"Igor E.","family":"Brodsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,10,20]]},"references-count":46,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2022,10,20]]}},"alternative-id":["10.1128\/iai.00203-22"],"URL":"https:\/\/doi.org\/10.1128\/iai.00203-22","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2022.05.05.490820","asserted-by":"object"}]},"ISSN":["0019-9567","1098-5522"],"issn-type":[{"value":"0019-9567","type":"print"},{"value":"1098-5522","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,20]]},"assertion":[{"value":"2022-05-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00203-22"}}