{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T07:18:40Z","timestamp":1791098320595,"version":"4.1.0"},"reference-count":33,"publisher":"American Society for Microbiology","issue":"9","license":[{"start":{"date-parts":[[2006,9,1]],"date-time":"2006-09-01T00:00:00Z","timestamp":1157068800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2006,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            The virulence of the pathogenic\n            <jats:italic>Yersinia<\/jats:italic>\n            species depends on a plasmid-encoded type III secretion system that transfers six Yop effector proteins into host cells. One of these proteins, YopJ, has been shown to disrupt host cell signaling pathways involved in proinflammatory cytokine production and to induce macrophage apoptosis in vitro. YopJ-dependent apoptosis in mesenteric lymph nodes has also been demonstrated in a mouse model of\n            <jats:italic>Yersinia pseudotuberculosis<\/jats:italic>\n            infection. These results suggest that YopJ attenuates the host innate and adaptive immune response during infection, but the role of YopJ during bubonic plague has not been completely established. We evaluated the role of\n            <jats:italic>Yersinia pestis<\/jats:italic>\n            YopJ in a rat model of bubonic plague following intradermal infection with a fully virulent\n            <jats:italic>Y. pestis<\/jats:italic>\n            strain and an isogenic\n            <jats:italic>yopJ<\/jats:italic>\n            mutant. Deletion of\n            <jats:italic>yopJ<\/jats:italic>\n            resulted in a twofold decrease in the number of apoptotic immune cells in the bubo and a threefold increase in serum tumor necrosis factor alpha levels but did not result in decreased virulence, systemic spread, or colonization levels in the spleen and blood. Our results indicate that YopJ is not essential for bubonic plague pathogenesis, even after peripheral inoculation of low doses of\n            <jats:italic>Y. pestis<\/jats:italic>\n            . Instead, the effects of YopJ appear to overlap and augment the immunomodulatory effects of other\n            <jats:italic>Y. pestis<\/jats:italic>\n            virulence factors.\n          <\/jats:p>","DOI":"10.1128\/iai.00219-06","type":"journal-article","created":{"date-parts":[[2006,8,22]],"date-time":"2006-08-22T22:13:07Z","timestamp":1156284787000},"page":"5126-5131","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":72,"title":["<i>Yersinia pestis<\/i>\n            YopJ Suppresses Tumor Necrosis Factor Alpha Induction and Contributes to Apoptosis of Immune Cells in the Lymph Node but Is Not Required for Virulence in a Rat Model of Bubonic Plague"],"prefix":"10.1128","volume":"74","author":[{"given":"Nadine","family":"Lemai\u0302tre","sequence":"first","affiliation":[{"name":"Laboratory of Zoonotic Pathogens"},{"name":"Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, Inserm U801, Lille F-50921, Universite\u0301 de Lille II, Faculte\u0301 de Me\u0301decine Henri Warembourg, Lille F-59045, Institut Pasteur de Lille, Lille F-59021, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florent","family":"Sebbane","sequence":"additional","affiliation":[{"name":"Laboratory of Zoonotic Pathogens"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Long","sequence":"additional","affiliation":[{"name":"Veterinary Branch"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Joseph Hinnebusch","sequence":"additional","affiliation":[{"name":"Laboratory of Zoonotic Pathogens"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.66.5.1878-1884.1998"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.71.7.3673-3681.2003"},{"key":"e_1_3_2_4_2","doi-asserted-by":"crossref","unstructured":"Butler T. 1983. 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