{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T07:18:44Z","timestamp":1791098324549,"version":"4.1.0"},"reference-count":52,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[2008,2,1]],"date-time":"2008-02-01T00:00:00Z","timestamp":1201824000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2008,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            In all\n            <jats:italic>Yersinia pestis<\/jats:italic>\n            strains examined, the adhesin\/invasin\n            <jats:italic>yadA<\/jats:italic>\n            gene is a pseudogene, yet\n            <jats:italic>Y. pestis<\/jats:italic>\n            is invasive for epithelial cells. To identify potential surface proteins that are structurally and functionally similar to YadA, we searched the\n            <jats:italic>Y. pestis<\/jats:italic>\n            genome for open reading frames with homology to\n            <jats:italic>yadA<\/jats:italic>\n            and found three: the bicistronic operon\n            <jats:italic>yadBC<\/jats:italic>\n            (YPO1387 and YPO1388 of\n            <jats:italic>Y. pestis<\/jats:italic>\n            CO92; y2786 and y2785 of\n            <jats:italic>Y. pestis<\/jats:italic>\n            KIM5), which encodes two putative surface proteins, and YPO0902, which lacks a signal sequence and likely is nonfunctional. In this study we characterized\n            <jats:italic>yadBC<\/jats:italic>\n            regulation and tested the importance of this operon for\n            <jats:italic>Y. pestis<\/jats:italic>\n            adherence, invasion, and virulence. We found that loss of\n            <jats:italic>yadBC<\/jats:italic>\n            caused a modest loss of invasiveness for epithelioid cells and a large decrease in virulence for bubonic plague but not for pneumonic plague in mice.\n          <\/jats:p>","DOI":"10.1128\/iai.00219-07","type":"journal-article","created":{"date-parts":[[2007,11,19]],"date-time":"2007-11-19T21:08:18Z","timestamp":1195506498000},"page":"578-587","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":44,"title":["<i>yadBC<\/i>\n            of\n            <i>Yersinia pestis<\/i>\n            , a New Virulence Determinant for Bubonic Plague"],"prefix":"10.1128","volume":"76","author":[{"given":"Stanislav","family":"Forman","sequence":"first","affiliation":[{"name":"Department of Microbiology, Immunology, and Molecular Genetics, University of Kentucky, Lexington, Kentucky 40536-0298"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine R.","family":"Wulff","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology, and Molecular Genetics, University of Kentucky, Lexington, Kentucky 40536-0298"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanya","family":"Myers-Morales","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology, and Molecular Genetics, University of Kentucky, Lexington, Kentucky 40536-0298"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clarissa","family":"Cowan","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology, and Molecular Genetics, University of Kentucky, Lexington, Kentucky 40536-0298"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert D.","family":"Perry","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology, and Molecular Genetics, University of Kentucky, Lexington, Kentucky 40536-0298"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan C.","family":"Straley","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology, and Molecular Genetics, University of Kentucky, Lexington, Kentucky 40536-0298"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","unstructured":"Current protocols in molecular biology. 2001"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.94.1.19-26.1967"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/7.6.1513"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0955-0674(03)00099-1"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0603456103"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200205077"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2005.03.004"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.68.8.4523-4530.2000"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.120163297"},{"key":"e_1_3_2_11_2","first-page":"156","volume":"120","year":"1996","unstructured":"Davis, K. 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