{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:31:07Z","timestamp":1787016667696,"version":"build-2736575974"},"reference-count":130,"publisher":"American Society for Microbiology","issue":"11","license":[{"start":{"date-parts":[[2023,11,16]],"date-time":"2023-11-16T00:00:00Z","timestamp":1700092800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/doi.org\/10.1128\/ASMCopyrightv2"},{"start":{"date-parts":[[2023,11,16]],"date-time":"2023-11-16T00:00:00Z","timestamp":1700092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100006342","name":"Association Vaincre la Mucoviscidose","doi-asserted-by":"crossref","award":["RIF20190502522"],"award-info":[{"award-number":["RIF20190502522"]}],"id":[{"id":"10.13039\/501100006342","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100006342","name":"Association Vaincre la Mucoviscidose","doi-asserted-by":"crossref","award":["RIF20180502320"],"award-info":[{"award-number":["RIF20180502320"]}],"id":[{"id":"10.13039\/501100006342","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001677","name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100020875","name":"Universit\u00e9 de Versailles Saint-Quentin-en-Yvelines","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100020875","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2023,11,16]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Cystic fibrosis (CF) is a human genetic disease caused by mutations in the\n                    <jats:italic>cystic fibrosis transmembrane conductance regulator<\/jats:italic>\n                    gene that encodes a chloride channel. The most severe clinical manifestation is associated with chronic pulmonary infections by pathogenic and opportunistic microbes.\n                    <jats:italic>Drosophila melanogaster<\/jats:italic>\n                    has become the invertebrate model of choice for modeling microbial infections and studying the induced innate immune response. Here, we review its contribution to the understanding of infections with six major pathogens associated with CF (\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    ,\n                    <jats:italic>Pseudomonas aeruginosa<\/jats:italic>\n                    ,\n                    <jats:italic>Burkholderia cepacia<\/jats:italic>\n                    ,\n                    <jats:italic>Mycobacterium abscessus<\/jats:italic>\n                    ,\n                    <jats:italic>Streptococcus pneumoniae,<\/jats:italic>\n                    and\n                    <jats:italic>Aspergillus fumigatus<\/jats:italic>\n                    ) together with the perspectives opened by the recent availability of two CF models in this model organism.\n                  <\/jats:p>","DOI":"10.1128\/iai.00240-23","type":"journal-article","created":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T09:08:31Z","timestamp":1697533711000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":10,"title":["<i>Drosophila melanogaster<\/i>\n                    as an organism model for studying cystic fibrosis and its major associated microbial infections"],"prefix":"10.1128","volume":"91","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2131-3703","authenticated-orcid":true,"given":"Hamadoun","family":"Tour\u00e9","sequence":"first","affiliation":[{"name":"Universit\u00e9 Paris-Saclay, UVSQ, INSERM, Infection et Inflammation , Montigny-le-Bretonneux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Louis","family":"Herrmann","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris-Saclay, UVSQ, INSERM, Infection et Inflammation , Montigny-le-Bretonneux, France"},{"name":"Assistance Publique-Ho\u0302pitaux de Paris, Ho\u0302pitaux Universitaires Ile-de-France Ouest, GHU Paris-Saclay, H\u00f4pital Raymond Poincare\u0301 , Garches, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1722-0707","authenticated-orcid":false,"given":"S\u00e9bastien","family":"Szuplewski","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris-Saclay, UVSQ, Laboratoire de G\u00e9n\u00e9tique et Biologie Cellulaire , Montigny-le-Bretonneux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7571-6519","authenticated-orcid":false,"given":"Fabienne","family":"Girard-Misguich","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris-Saclay, UVSQ, INSERM, Infection et Inflammation , Montigny-le-Bretonneux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2008.03.007"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.2570460"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.2475911"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.2772657"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1712984"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/360081a0"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/embo-reports\/kve232"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002329900529"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M402373200"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00142.2010"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2007.05.001"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1255825"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)12567-6"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60327-5"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2019.08.006"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2019.00603"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2018.05.022"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.71.6.3540-3550.2003"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1462-5822.2003.00329.x"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0027434"},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-15940-2"},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.25.022106.141615"},{"key":"e_1_3_1_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0092-8674(00)80172-5"},{"key":"e_1_3_1_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/bs.ctdb.2016.07.002"},{"key":"e_1_3_1_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.dci.2019.103468"},{"key":"e_1_3_1_27_2","doi-asserted-by":"publisher","DOI":"10.1534\/genetics.118.300223"},{"key":"e_1_3_1_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/febs.13235"},{"key":"e_1_3_1_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-18135-y"},{"key":"e_1_3_1_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgg.2020.02.004"},{"key":"e_1_3_1_31_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.54818"},{"key":"e_1_3_1_32_2","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2020104486"},{"key":"e_1_3_1_33_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.739357"},{"key":"e_1_3_1_34_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.201767"},{"key":"e_1_3_1_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/237232a0"},{"key":"e_1_3_1_36_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.21.9465"},{"key":"e_1_3_1_37_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri2194"},{"key":"e_1_3_1_38_2","doi-asserted-by":"publisher","DOI":"10.1042\/bss0710085"},{"key":"e_1_3_1_39_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1117311"},{"key":"e_1_3_1_40_2","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/8526385"},{"key":"e_1_3_1_41_2","doi-asserted-by":"publisher","DOI":"10.3920\/BM2019.0086"},{"key":"e_1_3_1_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jip.2017.09.008"},{"key":"e_1_3_1_43_2","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.27116-0"},{"key":"e_1_3_1_44_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006847"},{"key":"e_1_3_1_45_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0014743"},{"key":"e_1_3_1_46_2","doi-asserted-by":"publisher","DOI":"10.1159\/000210264"},{"key":"e_1_3_1_47_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200501113"},{"key":"e_1_3_1_48_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0901032"},{"key":"e_1_3_1_49_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.333807"},{"key":"e_1_3_1_50_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0506182103"},{"key":"e_1_3_1_51_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002421"},{"key":"e_1_3_1_52_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1000625"},{"key":"e_1_3_1_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2017.11.004"},{"key":"e_1_3_1_54_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2180-12-274"},{"key":"e_1_3_1_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2012.11.012"},{"key":"e_1_3_1_56_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00276-21"},{"key":"e_1_3_1_57_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02965-15"},{"key":"e_1_3_1_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijmm.2016.05.004"},{"key":"e_1_3_1_59_2","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2009.124"},{"key":"e_1_3_1_60_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1114907108"},{"key":"e_1_3_1_61_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.71.7.4059-4066.2003"},{"key":"e_1_3_1_62_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0409588102"},{"key":"e_1_3_1_63_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1914830117"},{"key":"e_1_3_1_64_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01637-07"},{"key":"e_1_3_1_65_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.72.10.5638-5645.2004"},{"key":"e_1_3_1_66_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms13823"},{"key":"e_1_3_1_67_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0205815"},{"key":"e_1_3_1_68_2","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.14063"},{"key":"e_1_3_1_69_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.01480-20"},{"key":"e_1_3_1_70_2","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms9020447"},{"key":"e_1_3_1_71_2","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.001462"},{"key":"e_1_3_1_72_2","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms9051065"},{"key":"e_1_3_1_73_2","doi-asserted-by":"publisher","DOI":"10.1002\/pro.3682"},{"key":"e_1_3_1_74_2","doi-asserted-by":"publisher","DOI":"10.1006\/mpat.2002.0504"},{"key":"e_1_3_1_75_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2005.00512.x"},{"key":"e_1_3_1_76_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2443.2007.01121.x"},{"key":"e_1_3_1_77_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2010.07.007"},{"key":"e_1_3_1_78_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00591-06"},{"key":"e_1_3_1_79_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI35147"},{"key":"e_1_3_1_80_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002299"},{"key":"e_1_3_1_81_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01459-18"},{"key":"e_1_3_1_82_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0911797106"},{"key":"e_1_3_1_83_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01646-08"},{"key":"e_1_3_1_84_2","doi-asserted-by":"publisher","DOI":"10.4161\/21597073.2014.964081"},{"key":"e_1_3_1_85_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26061497"},{"key":"e_1_3_1_86_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.478958"},{"key":"e_1_3_1_87_2","doi-asserted-by":"publisher","DOI":"10.1080\/13693780903148346"},{"key":"e_1_3_1_88_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-61779-539-8_32"},{"key":"e_1_3_1_89_2","doi-asserted-by":"publisher","DOI":"10.1086\/428587"},{"key":"e_1_3_1_90_2","doi-asserted-by":"publisher","DOI":"10.3109\/13693780903225813"},{"key":"e_1_3_1_91_2","doi-asserted-by":"publisher","DOI":"10.1086\/525044"},{"key":"e_1_3_1_92_2","doi-asserted-by":"publisher","DOI":"10.4161\/viru.1.6.13311"},{"key":"e_1_3_1_93_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkn224"},{"key":"e_1_3_1_94_2","doi-asserted-by":"publisher","DOI":"10.1002\/tox.21825"},{"key":"e_1_3_1_95_2","doi-asserted-by":"publisher","DOI":"10.5941\/MYCO.2017.45.4.233"},{"key":"e_1_3_1_96_2","doi-asserted-by":"publisher","DOI":"10.1111\/ina.12350"},{"key":"e_1_3_1_97_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0011467"},{"key":"e_1_3_1_98_2","doi-asserted-by":"publisher","DOI":"10.1038\/ismej.2009.95"},{"key":"e_1_3_1_99_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2011.07937.x"},{"key":"e_1_3_1_100_2","doi-asserted-by":"publisher","DOI":"10.1002\/mbo3.67"},{"key":"e_1_3_1_101_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00768-12"},{"key":"e_1_3_1_102_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2015.11.051"},{"key":"e_1_3_1_103_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1011257"},{"key":"e_1_3_1_104_2","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.14819"},{"key":"e_1_3_1_105_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01257-09"},{"key":"e_1_3_1_106_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200604-571ST"},{"key":"e_1_3_1_107_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2015.09.007"},{"key":"e_1_3_1_108_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-020-0331-1"},{"key":"e_1_3_1_109_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2013.06.011"},{"key":"e_1_3_1_110_2","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.00777-23"},{"key":"e_1_3_1_111_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1812984115"},{"key":"e_1_3_1_112_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1008069"},{"key":"e_1_3_1_113_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-022-01204-x"},{"key":"e_1_3_1_114_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2009.12.007"},{"key":"e_1_3_1_115_2","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2015-207360"},{"key":"e_1_3_1_116_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dku024"},{"key":"e_1_3_1_117_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.0030026"},{"key":"e_1_3_1_118_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002970"},{"key":"e_1_3_1_119_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1007022"},{"key":"e_1_3_1_120_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.0030041"},{"key":"e_1_3_1_121_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005126"},{"key":"e_1_3_1_122_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2005.08.005"},{"key":"e_1_3_1_123_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2007.03.049"},{"key":"e_1_3_1_124_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000184"},{"key":"e_1_3_1_125_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1214550110"},{"key":"e_1_3_1_126_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006300"},{"key":"e_1_3_1_127_2","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.000226"},{"key":"e_1_3_1_128_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12275-018-8331-9"},{"key":"e_1_3_1_129_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2016.11.023"},{"key":"e_1_3_1_130_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1913127117"},{"key":"e_1_3_1_131_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.252785099"}],"container-title":["Infection and Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/iai.00240-23","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/iai.00240-23","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,16]],"date-time":"2023-11-16T09:02:44Z","timestamp":1700125364000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/iai.00240-23"}},"subtitle":[],"editor":[{"given":"Anthony R.","family":"Richardson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2023,11,16]]},"references-count":130,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2023,11,16]]}},"alternative-id":["10.1128\/iai.00240-23"],"URL":"https:\/\/doi.org\/10.1128\/iai.00240-23","relation":{},"ISSN":["0019-9567","1098-5522"],"issn-type":[{"value":"0019-9567","type":"print"},{"value":"1098-5522","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,16]]},"assertion":[{"value":"2023-10-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00240-23"}}