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Our results show a modulation in the TCR V\u03b2 repertoire during CL and after antigen stimulation of patients' cells. Vaccination, however, leads to a broad expansion of different V\u03b2 TCRs. We also observed an association between TCR V\u03b212 expression, T-cell activation, and gamma interferon production upon in vitro priming with\n                    <jats:italic>Leishmania.<\/jats:italic>\n                    Collectively, these results both indicate that infection with live parasites or exposure to parasite antigen can modulate the TCR V\u03b2 repertoire and suggest that TCR V\u03b212 may be implicated in the response to\n                    <jats:italic>Leishmania<\/jats:italic>\n                    .\n                  <\/jats:p>","DOI":"10.1128\/iai.00265-06","type":"journal-article","created":{"date-parts":[[2006,7,21]],"date-time":"2006-07-21T20:24:50Z","timestamp":1153513490000},"page":"4757-4765","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":21,"title":["Characterization of the T-Cell Receptor V\u03b2 Repertoire in the Human Immune Response against\n                    <i>Leishmania<\/i>\n                    Parasites"],"prefix":"10.1128","volume":"74","author":[{"given":"Jorge","family":"Clare\u0302ncio","sequence":"first","affiliation":[{"name":"Centro de Pesquisas Gonc\u0327alo Moniz, FIOCRUZ, Rua Waldemar Falca\u0303o, 121, Salvador, Bahia 40296-710, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camila I.","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Centro de Pesquisas Gonc\u0327alo Moniz, FIOCRUZ, Rua Waldemar Falca\u0303o, 121, Salvador, Bahia 40296-710, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glo\u0301ria","family":"Bomfim","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina, UFBA, Prac\u0327a XV de Novembro, S\/N, Largo do Terreiro de Jesus Salvador, Bahia 40025-010, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margarida M.","family":"Pompeu","sequence":"additional","affiliation":[{"name":"Nu\u0301cleo de Medicina Tropical, UFC, Rua Alexandre Barau\u0301na, 949, Fortaleza, Ceara 60430-160, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Jania","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Nu\u0301cleo de Medicina Tropical, UFC, Rua Alexandre Barau\u0301na, 949, Fortaleza, Ceara 60430-160, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theolis C.","family":"Barbosa","sequence":"additional","affiliation":[{"name":"Centro de Pesquisas Gonc\u0327alo Moniz, FIOCRUZ, Rua Waldemar Falca\u0303o, 121, Salvador, Bahia 40296-710, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastia\u0303o","family":"Souza-Neto","sequence":"additional","affiliation":[{"name":"Centro de Pesquisas Gonc\u0327alo Moniz, FIOCRUZ, Rua Waldemar Falca\u0303o, 121, Salvador, Bahia 40296-710, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edgar M.","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina, UFBA, Prac\u0327a XV de Novembro, S\/N, Largo do Terreiro de Jesus Salvador, Bahia 40025-010, Brazil"},{"name":"Instituto de Investigac\u0327a\u0303o em Imunologia, Sa\u0303o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cla\u0301udia","family":"Brodskyn","sequence":"additional","affiliation":[{"name":"Centro de Pesquisas Gonc\u0327alo Moniz, FIOCRUZ, Rua Waldemar Falca\u0303o, 121, Salvador, Bahia 40296-710, Brazil"},{"name":"Departamento de Biointerac\u0327a\u0303o, ICS, UFBA, Av. 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